Análise De Parâmetros Bioquímicos Do Sangue De Camundongos Tratados Com Lidocaína

Abstract

Estudos anteriores sobre os efeitos colaterais da Lidocaína mostraram que ao ser administrada cronicamente em camundongos, causava lesões nos rins e no fígado. Neste trabalho, avaliou-se, por meio de testes bioquímicos (Bilirrubina, Transaminase Pirúvica -TGP, Transaminase Oxalacética - TGO e Creatinina), a hepatotoxicidade e a nefrotoxicidade do anestésico. Em nossas condições experimentais e, após administrações diárias durante 14 dias, não se observaram alterações significativas em tais marcadores bioquímicos plasmáticos.

Are silymarin and N‐acetylcysteine able to prevent liver damage mediated by multiple factors? Findings against ethanol plus LPS‐induced liver injury in mice

“…PGT is hepato-specific, whereas OGT is found in a variety of organs, including the heart, skeletal muscle, and liver, and lesser amounts in the kidneys and pancreas. [34] Alcohol-induced liver damage can cause lasting damage to mitochondria and thus to the liver parenchyma. As a result of increased membrane permeability caused by tissue damage, enzymes are released and diffuse through the capillaries, entering the bloodstream and subsequently causing an increase in plasma concentration, [35] which was evident in mice that received the vehicle, ethanol, and LPS.…”

“…PGT is hepato‐specific, whereas OGT is found in a variety of organs, including the heart, skeletal muscle, and liver, and lesser amounts in the kidneys and pancreas. [ 34 ]…”