The purpose of this study was to analyze the impact of the COVID-19 disaster on MSME actors in Mataram City, West Nusa Tenggara Province. The approach used in this research is qualitative research. Data collection techniques used are observation, interviews and documents. Determination of informants in this study using purposive sampling. The informants in this study consisted of 4 key informants, 10 main informants and 3 additional informants. The technique of checking the validity of this research is using triangulation technique. The results showed that the impact of the COVID-19 disaster on MSME actors in Mataram City was very influential and the business of MSME actors experienced a decline. This is because the businesses of many MSME actors have closed, due to restrictions on activities made by the government. So that many MSME actors reduce employees to reduce losses that occur. As a result, a lot of unemployment occurs due to Termination of Employment (PHK). The steps taken to develop a business during the Covid-19 era are by doing promotions online and by word of mouth (manually). Then the income of MSMEs during the Covid-19 period decreased compared to before Covid-19. The efforts made by the Mataram City government in increasing MSMEs during the COVID-19 pandemic are tax relaxation, providing Social Safety Nets (JPS), providing Social Assistance (Bansos) providing training and equipment, issuing pre-employment cards, providing funds or equipment, helping packaging , as well as helping to market the results of SMEs.