Analyses of Nonsteroidal Anti-inflammatory Drugs in Human Plasma Using Dispersive Nano Solid-Phase Extraction and High-Performance Liquid Chromatography

Ali, Imran; Kulsum, Umma; ALOthman, Zeid A.; Saleem, Kishwar

doi:10.1007/s10337-015-3020-x

Cited by 26 publications

(9 citation statements)

References 47 publications

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“…The synthesized iron NPs were found to be crystalline in nature due to the presence of Fe 2 O 3 , Fe 3 O 4 and FeOOH. These results corresponded well with the reported literature .…”

Section: Resultssupporting

confidence: 93%

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Functionalized nanoparticles based solid-phase membrane micro-tip extraction and high-performance liquid chromatography analyses of vitamin B complex in human plasma

et al. 2016

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Iron nanoparticles were prepared by a green method following functionalization using 1-butyl-3-methylimidazolium bromide. 1-Butyl-3-methylimidazole iron nanoparticles were characterized using FTIR spectroscopy, energy dispersive X-ray fluorescence, X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The nanoparticles were used in solid-phase membrane micro-tip extraction to separate vitamin B complex from plasma before high-performance liquid chromatography. The optimum conditions obtained were sorbent (15 mg), agitation time (30 min), pH (9.0), desorbing solvent [water (5 mL) + methanol (5 mL) + sodium hydroxide (0.1 N) + acetic acid (d = 1.05 kg/L, pH 5.5), desorbing volume (10 mL) and desorption time (30 min). The percentage recoveries of all the eight vitamin B complex were from 60 to 83%. A high-performance liquid chromatography method was developed using a PhE column (250 × 4.6 mm, 5.0 μm) and water/acetonitrile (95:5, v/v; pH 4.0 with 0.1% formic acid) mobile phase. The flow rate was 1.0 mL/min with detection at 270 and 210 nm. The values of the capacity, separation and resolution factor were 0.57-39.47, 1.12-6.00 and 1.84-26.26, respectively. The developed sample preparation and chromatographic methods were fast, selective, inexpensive, economic and reproducible. The developed method can be applied for analyzing these drugs in biological and environmental matrices.

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“…The synthesized iron NPs were found to be crystalline in nature due to the presence of Fe 2 O 3 , Fe 3 O 4 and FeOOH. These results corresponded well with the reported literature .…”

Section: Resultssupporting

confidence: 93%

“…Iron nanoparticles (NINPs) were synthesized using black tea extract . Black tea extract was prepared by heating 500 mL of water containing 30 g of tea for 1 h at 80°C.…”

Section: Methodsmentioning

confidence: 99%

Functionalized nanoparticles based solid-phase membrane micro-tip extraction and high-performance liquid chromatography analyses of vitamin B complex in human plasma

et al. 2016

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“…Nowadays, PFP columns are gaining importance for the separation of different molecules. During our earlier work (Ali, Kulsum, Al-Othman, & Saleem, 2016;Al-Othman, Al-Warthan, Aboul-Enein, Al-Za'abi, & Ali, 2015), it was demonstrated that this column is efficient, selective and reproducible. This column may be highly useful in the separation of a variety of molecules if its working mechanism, at a supramolecular level, is determined exactly.…”

mentioning

confidence: 97%

Supramolecular separation mechanism of pentafluorophenyl column using ibuprofen and omeprazole as markers: LC‐MS and simulation study

Hussain

Alajmi

Ali

2018

Biomedical Chromatography

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The pentafluorophenyl (PFP) column is emerging as a new advancement in separation science to analyze a wide range of analytes and, thus, its separation mechanism at supramolecular level is significant. We developed a mechanism for the separation of ibuprofen and omeprazole using different combinations (ranging from 50:50 to 60:40) of water-acetonitrile containing 0.1% formic acid as the mobile phase. The column used was Waters Acquity UPLC HSS PFP (75 × 2.1 mm, 1.8 μm). The reverse order of elution was observed in different combinations of the mobile phases. The docking study indicated hydrogen bonding between ibuprofen and PFP stationary phase (binding energy was -11.30 kJ/mol). Separation at PFP stationary phase is controlled by hydrogen bonding along with π-π interactions. This stationary phase may be used to analyze both aromatic and aliphatic analytes. The developed mechanism will be useful to separate various analytes by considering the possible interactions, leading to saving of energy, time and money. In addition, this work will be highly useful in preparative chromatography where separation is the major problem at a large scale. Moreover, the developed LC-MS-QTOF method may be used to analyze ibuprofen and omeprazole in an unknown sample owing to the low value of detection limits.

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“…MTMOS–MPTMS offered better sensitivity (LOD of 0.10–0.29 μg/L) and RR of 95.90–101.3% toward selected nonsteroidal antiinflammatory drugs (NSAIDs), as compared to the commercial cyano adsorbent (LOD of 0.22–0.32 μg/L and RR of 82.2–95.1%). SPE employing MTMOS–MPTMS also showed higher or comparable sensitivity and RR when compared with other sample preparation methods such as stir bar sorptive extraction (LOD = 0.23–0.31 μg/L; RR = 76.8–116.0%), dispersive nano solid‐phase extraction (LOD = 1.5–5.8 μg/L; RR = 98.7–100%), SPE (LOD = 3–16 μg/L; RR = 73.2–92.3%), and stir rod sorptive extraction (LOD = 0.09–0.25 μg/L; RR = 75.6–112.3%) for NSAIDs determination. The good extraction performance could be due to the rich thiol groups on the MTMOS–MPTMS surface that allowed the occurrence of dipole–dipole interaction between H atoms of the thiol groups and N or O atoms of the NSAIDs.…”

Section: Application Of Organic–inorganic Hybrid Based Adsorbents In Spementioning

confidence: 89%

Advances in organic–inorganic hybrid sorbents for the extraction of organic and inorganic pollutants in different types of food and environmental samples

Kamaruddin

Ibrahim

et al. 2017

J of Separation Science

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The efficiency of the extraction and removal of pollutants from food and the environment has been an important issue in analytical science. By incorporating inorganic species into an organic matrix, a new material known as an organic-inorganic hybrid material is formed. As it possesses high selectivity, permeability, and mechanical and chemical stabilities, organic-inorganic hybrid materials constitute an emerging research field and have become popular to serve as sorbents in various separaton science methods. Here, we review recent significant advances in analytical solid-phase extraction employing organic-inorganic composite/nanocomposite sorbents for the extraction of organic and inorganic pollutants from various types of food and environmental matrices. The physicochemical characteristics, extraction properties, and analytical performances of sorbents are discussed; including morphology and surface characteristics, types of functional groups, interaction mechanism, selectivity and sensitivity, accuracy, and regeneration abilities. Organic-inorganic hybrid sorbents combined with extraction techniques are highly promising for sample preparation of various food and environmental matrixes with analytes at trace levels.

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Analyses of Nonsteroidal Anti-inflammatory Drugs in Human Plasma Using Dispersive Nano Solid-Phase Extraction and High-Performance Liquid Chromatography

Cited by 26 publications

References 47 publications

Functionalized nanoparticles based solid-phase membrane micro-tip extraction and high-performance liquid chromatography analyses of vitamin B complex in human plasma

Functionalized nanoparticles based solid-phase membrane micro-tip extraction and high-performance liquid chromatography analyses of vitamin B complex in human plasma

Supramolecular separation mechanism of pentafluorophenyl column using ibuprofen and omeprazole as markers: LC‐MS and simulation study

Advances in organic–inorganic hybrid sorbents for the extraction of organic and inorganic pollutants in different types of food and environmental samples

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