2022
DOI: 10.1016/j.jchromb.2022.123458
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Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia

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Cited by 5 publications
(3 citation statements)
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“…The up-regulation of these genes at the same time is reported in Qiburi and colleagues' investigation. 25 In the original data from GSE157824, an inverse correlation is reported for the regulation of IGF1 and HMOX1 that may reflect the complex process of plasma effect of cell function.…”
Section: Ppi Network Analysis As a Useful Tool Is Applied To Evaluate...mentioning
confidence: 99%
“…The up-regulation of these genes at the same time is reported in Qiburi and colleagues' investigation. 25 In the original data from GSE157824, an inverse correlation is reported for the regulation of IGF1 and HMOX1 that may reflect the complex process of plasma effect of cell function.…”
Section: Ppi Network Analysis As a Useful Tool Is Applied To Evaluate...mentioning
confidence: 99%
“…Eerdun Wurile (EW) consists of 29 herbal medicines and is commonly applied for the treatment of nervous system dysfunction, including memory impairment, blurred facial expression, dizziness, and drowsiness [4]. Currently, the administration of EW in the therapeutic application of neuronal dysfunction is attracting increasing attention and many related studies have been conducted in China.…”
Section: Introductionmentioning
confidence: 99%
“…TLR4, a toll-like receptor, is a type I transmembrane type protein widely distributed in brain neurons, microglia and astrocytes [8]. Lipopolysaccharide (LPS) is a specific exogenous ligand for TLR4, which can bind to the receptor TLR4 and activate the MyD88-dependent pathway as a downstream signaling to transduce inflammatory signals and also activate NF-κB (nuclear factor kappa B) [9,10]. NF-κB is a critical nuclear transcription factor in early immune responses and cellular inflammation and promotes the secretion of cytokines for secretion, such as TNF-α (tumor necrosis factor-α), IL-6, IL-1β, and NO [11,12].…”
Section: Introductionmentioning
confidence: 99%