We propose a novel method for signal storage and encryption, called single-beam multiplexing encoding. The single beam is composed of an inside signal beam and an outside reference beam. The signal beam is amplitude modulated, and the reference beam is phase modulated. The dual modulation is implemented by a spatial light modulator (SLM). Multiplexing holography with different reference beams from different directions, called directional multiplexing, is analyzed in detail. With an SLM based on a twisted nematic liquid crystal display, we demonstrate a single-beam directional multiplexing method using a holographic encoding technique, and the retrieved signals are presented. This encoding system is more stable, miniaturized, and flexible. It should be of great interest for applications in signal encryption as well as for high-capacity data storage.