Analysis of age-related changes in the functional morphologies of salivary glands in mice

Choi, Jeong Seok; Park, In Suh; Kim, Seok Ki; Lim, Jae Yol; Kim, Young Mo

doi:10.1016/j.archoralbio.2013.07.008

Cited by 79 publications

(60 citation statements)

References 40 publications

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“…(12–15) In these studies, histologic examinations demonstrated that during aging, the parenchyma of salivary glands is gradually replaced by fat, fibrous connective tissue, oncocytes, and apoptotic salivary epithelial cells. (12–15) However, the relationship between age and salivary flow rates is controversial. Age-related salivary glands showed that salivary flow rate in elderly individuals were lower than that in young individuals.…”

Section: Introductionmentioning

confidence: 99%

Relationship between hyposalivation and oxidative stress in aging mice

Yoda

Matsuno

Omata

et al. 2017

J. Clin. Biochem. Nutr.

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The increase in oxidative stress that accompanies aging has been implicated in the abnormal advance of aging and in the onset of various systemic diseases. However, the details of what effects the increase in oxidative stress that accompanies aging has on saliva secretion are not known. In this study, naturally aging mice were used to examine the stimulated whole saliva flow rate, saliva and serum oxidative stress, antioxidant level, submandibular gland H-E staining, and immunofluorescence staining to investigate the effect of aging on the volume of saliva secretion and the relationship with oxidative stress, as well as the effect of aging on the structure of salivary gland tissue. The stimulated whole saliva flow rate decreased significantly with age. Also, oxidative stress increased significantly with age. Antioxidant levels, however, decreased significantly with age. Structural changes of the submandibular gland accompanying aging included atrophy of parenchyma cells and fatty degeneration and fibrosis of stroma, and the submandibular gland weight ratio decreased. These results suggest that oxidative stress increases with age, not just systemically but also locally in the submandibular gland, and that oxidative stress causes changes in the structure of the salivary gland and is involved in hyposalivation.

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Section: Introductionmentioning

confidence: 99%

Relationship between hyposalivation and oxidative stress in aging mice

Yoda

Matsuno

Omata

et al. 2017

J. Clin. Biochem. Nutr.

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“…10 Although no etiological reports regarding cell infiltration in the pancreases of C57BL/6, A/J, and AKR/N mice exist, a recent study reported that C57BL/6 developed age-related exocrinopathy in the salivary glands at approximately 90 weeks of age. 24 Females tended to show pancreatic cell infiltration more frequently than males in this study. Estrogen and progesterone are thought to exacerbate the autoimmune responses both in humans and mice, 25 and testosterone acts as a protective factor in the autoimmune phenotype of B6.MRLc1 mice.…”

Section: Discussionmentioning

confidence: 76%

Pathogenetic role of an autoimmune susceptibility locus derived from MRL/MpJ strain chromosome 1 in chronic pancreas inflammation

Okada

Nakamura

Ichii

et al. 2014

Lupus

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“…In particular, the EGCG or amifostine group contained higher numbers of mucin containing acini than the RI group. Because mucin has low solubility, high viscosity, elasticity, and lubricity, and adheres well to surfaces, it is an important component of mastication, speech, swallowing, and the removal of bacteria from oral mucosa [29]. The EGCG or amifostine group also exhibited less periductal and perivascular fibrosis than the RI group, and periductal fibrosis causes ductal stiffness and secretion disorders [29].…”

Section: Discussionmentioning

confidence: 99%

“…Because mucin has low solubility, high viscosity, elasticity, and lubricity, and adheres well to surfaces, it is an important component of mastication, speech, swallowing, and the removal of bacteria from oral mucosa [29]. The EGCG or amifostine group also exhibited less periductal and perivascular fibrosis than the RI group, and periductal fibrosis causes ductal stiffness and secretion disorders [29]. Accordingly, we believe our observations of increased mucin quantities and reduced ductal fibrosis in EGCG or amifostine group indicate less gland dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective Effect of Epigallocatechin-3-Gallate on Salivary Gland Dysfunction After Radioiodine Ablation in a Murine Model

Choi

Park

et al. 2016

Clin Exp Otorhinolaryngol

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Objectives.Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG damage have not been well investigated. The authors investigated the morphometric and functional effects of epigallocatechin-3-gallate (EGCG) administered prior to RI therapy and compared this with the effects of amifostine (a well-known antioxidant) in a murine model of RI sialadenitis.Methods.Four-week-old female C57BL/6 mice (n=48) were divided into four groups; a normal control group, a RI-treated group (0.01 mCi/g mouse, orally), an EGCG and RI-treated group, and an amifostine and RI-treated group. Animals in these groups were divided into 3 subgroups and euthanized at 15, 30, and 90 days post-RI treatment. Salivary flow rates and lag times were measured, and morphologic and histologic examinations and TUNEL (terminal deoxynucleotidyl transferase biotin-dUDP nick end labeling) assays were performed. Changes in salivary 99mTc pertechnetate uptake and excretion were followed by single-photon emission computed tomography.Results.Salivary flow rates and lag times to salivation in the EGCG or amifostine groups were better than in the RI-treated group. Histologic examinations of SGs in the EGCG or amifostine group showed more mucin-rich parenchyma and less periductal fibrosis than in the RI-treated group. Fewer apoptotic cells were observed in acini, ducts, and among endothelial cells in the EGCG or amifostine group than in the RI group. In addition, patterns of 99mTc pertechnetate excretion were quite different in the EGCG or amifostine group than in the RI group.Conclusion.EGCG supplementation before RI therapy could protect from RI-induced SG damage in a manner comparable to amifostine, and thus, offers a possible means of preventing SG damage by RI.

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Analysis of age-related changes in the functional morphologies of salivary glands in mice

Cited by 79 publications

References 40 publications

Relationship between hyposalivation and oxidative stress in aging mice

Relationship between hyposalivation and oxidative stress in aging mice

Pathogenetic role of an autoimmune susceptibility locus derived from MRL/MpJ strain chromosome 1 in chronic pancreas inflammation

Radioprotective Effect of Epigallocatechin-3-Gallate on Salivary Gland Dysfunction After Radioiodine Ablation in a Murine Model

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