Marble quarries are quite dangerous environments in which rock falls may occur. As many workers operate in these sites, it is necessary to deal with the matter of safety at work, checking and monitoring the stability conditions of the rock mass. In this paper, some results of an innovative analysis method are shown. It is based on the combination of Distributed Optical Fiber Sensors (DOFS), digital photogrammetry through Unmanned Aerial Vehicle (UAV), topographic, and geotechnical monitoring systems. Although DOFS are currently widely used for studying infrastructures, buildings and landslides, their use in rock marble quarries represents an element of peculiarity. The complex morphologies and the intense temperature range that characterize this environment make this application original. The selected test site is the Lorano open pit which is located in the Apuan Alps (Italy); here, a monitoring system consisting of extensometers, crackmeters, clinometers and a Robotic Total Station has been operating since 2012. From DOFS measurements, strain and temperature values were obtained and validated with displacement data from topographic and geotechnical instruments. These results may provide useful fundamental indications about the rock mass stability for the safety at work and the long-term planning of mining activities.