Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students

Du, Qian; Ni, Shenglou; Fu, Yingyun; Liu, Sanhai

doi:10.1155/2018/2907812

Cited by 30 publications

(31 citation statements)

References 16 publications

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“…Consistent with previous observational studies (Ma et al, 2015;Du et al, 2018), we also found that insomnia has a causal effect to increase the risk of mouth ulcers. Insomnia will lead to late bedtime, which can disturb the secretion of hormones, such as growth hormone, cortisol, and adrenocorticotropic hormone (Ma et al, 2015).…”

Section: Discussionsupporting

confidence: 92%

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

et al. 2020

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BackgroundAlthough the association between mouth ulcers and psychiatric traits has been reported by observational studies, their causal relationship remains unclear. Mendelian randomization (MR), powered by large-scale genome-wide association studies (GWAS), provides an opportunity to clarify the causality between mouth ulcers and psychiatric traits.MethodsWe collected summary statistics of mouth ulcers (sample size n = 461,106) and 10 psychiatric traits from the largest publicly available GWAS on Europeans, including anxiety disorder (n = 83,566), attention deficit/hyperactivity disorder (n = 53,293), autism spectrum disorder (n = 46,350), bipolar disorder (n = 51,710), insomnia (n = 1,331,010), major depressive disorder (n = 480,359), mood instability (n = 363,705), neuroticism (n = 168,105), schizophrenia (n = 105,318), and subjective wellbeing (n = 388,538). We applied three two-sample bi-directional MR analysis methods, namely the Inverse Variance Weighted (IVW) method, the MR pleiotropy residual sum and outlier (MR-PRESSO) method, and the weighted median method, to assess the causal relationship between each psychiatric trait and mouth ulcers.ResultsWe found significant effects of autism spectrum disorder, insomnia, major depressive disorder, and subjective wellbeing on mouth ulcers, with the corresponding odds ratio (OR) from the IVW method being 1.160 [95% confidence interval (CI): 1.066–1.261, P = 5.39 × 10–4], 1.092 (1.062–1.122, P = 3.37 × 10–10), 1.234 (1.134–1.342, P = 1.03 × 10–6), and 0.703 (0.571–0.865, P = 8.97 × 10–4), respectively. We also observed suggestive evidence for mood instability to cause mouth ulcers [IVW, OR = 1.662 (1.059–2.609), P = 0.027]. These results were robust to weak instrument bias and heterogeneity. We found no evidence on causal effects between other psychiatric traits and mouth ulcers, in either direction.ConclusionOur findings suggest a protective effect of subjective wellbeing and risk effects of autism spectrum disorder, insomnia, major depressive disorder, and mood instability on mouth ulcers. These results clarify the causal relationship between psychiatric traits and the development of mouth ulcers.

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Section: Discussionsupporting

confidence: 92%

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

et al. 2020

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“…The total rate of Xerostomia among RAS patients was 45.8%; and it was 79% among major RAS patients with significant associated OR= 3.3 times, 95%CI =1.0-11.4, p=0.04) (Table 6). This result is in agreement with others studies that reported a significant association between Xerostomia and RAS [26,27]. This result can be explained by the fact that almost all of potential factors of RAS occur combine with another symptom which is mouth dryness (Xerostomia), which might be having a role in RAS occurrence.…”

Section: Discussionsupporting

confidence: 93%

The Association of Elevated Serum IgE and Xerostomia with Recurrent Aphthous Stomatitis

Shamahy¹

2019

OJDOH

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Background and objectives: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal diseases. This study aimed to determine the prevalence of RAS, the association of Immunoglobulin E with RAS and potential risk factors of RAS in patients at dental clinics of Sana'a universities in Sana'a city, Yemen. Subjects and methods:A cross-sectional study was conducted from January to December 2017 and includes 2164 patients. The patients interviewed and examined by dentists and 72 were clinically diagnosed to have RAS. The patients with RAS responded to a questionnaire that included demographic background, Qat chewing habits, smoking habits, history and course of RAS episodes. They were also subjected to laboratory tests, including determination of serum IgE levels and xerostomia. Results:The crude prevalence of RAS was 3.3%; female prevalence was 3.8% slightly higher than 2.4% of the male. There was a higher rate of RAS in age group 16-25 years (12.3%) and age group 26-35 years (9.3%) with OR=7 times and 4.1 times respectively (p<0.001). While lower rates of RAS were occurred in children under 15 years (0.41%) and older age (0.4%), (<0.001). The Mean±SD of IgE level for major RAS patients was 233±15.3IU/ml; while for minor was 127±17.3IU/ml. There was association between elevated IgE, Xerostomia, smoking habit, and chewing Qat and occurrence of major RAS (OR=6.4, 3.3, 26.8,and 7.1 respectively). Conclusion:Elevated IgE levels and xerostomia may be considered as part of the RAS patient's work-up. Further research is needed to identify biological mechanisms that account for the observed associations.

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“…Furthermore, the prevalence of RAS was 55% and 35.6% discovered in the dental clinic as of 2010–2012 and 2014-2015, respectively [ 1 , 2 ]. Other studies carried out in the midst of the population of 18-year-old adolescents in Brazil discovered to be 24.9% [ 3 ], about 10.84% RAS were also discovered in Turkey [ 4 ], 14% was reported in the female dental students in King Khalid University Saudi Arabia [ 5 ], and 29.38% was reported in the college students in Beijing University of Chinese Medicine [ 6 ]. RAS is considered as a multifactorial process of unknown etiology, in which various triggering factors and an immunological disturbance are combined, including genetic [ 7 , 8 ], vitamin B-12, folate, and iron deficiency [ 9 , 10 ] and an allergic condition, such as atopy [ 11 , 12 ] Pain or unpleasant feeling and its recurrency in the oral cavity are always complained by an individual that has RAS, and this condition makes researchers interested in discovering the pathogenesis of RAS and its ultimate goal in finding the appropriate novel therapy [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients

Nur’aeny

Gurnida

Suwarsa

et al. 2021

International Journal of Dentistry

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Objective. To investigate the DNA methylation using pyrosequencing and its effects on the upregulation of IL6 mRNA in patients with recurrent aphthous stomatitis (RAS) in connection with hematinic deficiency and atopy. Material and Methods. This cross-sectional study was conducted at Dr. Hasan Sadikin Hospital, Bandung, from January–March 2019 and was approved by the Health Research Ethics Committee of Universitas Padjadjaran (Ethics No. 990/UN6.KEP/EC/2018). Furthermore, the subjects had RAS ulcers with a history of at least twice a year along with atopy and dietary imbalance with no history of recurrent intraoral herpes or any systemic diseases. This study was performed on 23 RAS patients and 21 healthy subjects, and the sampling was carried out consecutively. The blood samples were collected from all the subjects, and then, the DNA and RNA were extracted from the peripheral blood mononuclear cells (PBMCs). Consequently, the bisulfite-modified DNA was used to confirm the methylation status of the IL6 gene promoter through the pyrosequencing method. The methylation levels of the IL6 promoter were assessed by a reverse transcriptase-polymerase chain reaction technique. The gene expression of RAS and the control group was analyzed by the 2−ΔΔCT method. The statistical analysis using the Mann–Whitney U test was conducted to evaluate IL6 mRNA levels and DNA methylation with p value <0.05 considered to be statistically significant. Result. The IL6 mRNA levels were approximately 1.88-fold in RAS patients, and there was a significant relationship between the expression of the IL6 gene and the increased risk of RAS p < 0.001 . It was reported that four out of six sites in the cytosine phosphate guanine (CpG) island IL6 promoter had a lower degree of methylation, and two other sites in patients with RAS had greater methylation compared with control, but not statistically significant. Conclusion. This study showed the upregulation of IL6 mRNA levels in RAS patients compared to control. DNA methylation in the present study is at sites 566–658, whereas the location of the IL6 promoter is at sites 1–1684. Thus, it would be necessary conducting some research at other CpG sites of IL6 promoter islands to determine the status of DNA methylation.

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Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students

Cited by 30 publications

References 16 publications

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

The Association of Elevated Serum IgE and Xerostomia with Recurrent Aphthous Stomatitis

The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients

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