Analysis of Distribution in the Human, Pig, and Rat Genomes Points toward a General Subtelomeric Origin of Minisatellite Structures

Amarger, Valérie; Guyader, Dominique; Yerle, Martine M.; Apiou, Françoise; Pinton, Philippe; Giraudeau, Fabienne; Monfouilloux, Sylvaine; Lathrop, M; Dutrillaux, Bernard; Buard, Jérǒme; Vergnaud, Gilles

doi:10.1006/geno.1998.5617

Cited by 13 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the pig, rat and mouse genomes show lower levels of subtelomeric clustering (66%, 30% and 15%, respectively) [103,104]. Closer analysis shows that interstitial sites in pig and rat [103] often correspond to terminal cytogenetic bands in human. This suggests that minisatellites are created near telomeres and that their internalisation arises from secondary events resulting from rearrangements involving chromosome ends.…”

Section: Minisatellites In Non-human Organismsmentioning

confidence: 67%

“…In humans, about 90% of minisatellites are localised in subtelomeric regions [103]. In contrast, the pig, rat and mouse genomes show lower levels of subtelomeric clustering (66%, 30% and 15%, respectively) [103,104]. Closer analysis shows that interstitial sites in pig and rat [103] often correspond to terminal cytogenetic bands in human.…”

Section: Minisatellites In Non-human Organismsmentioning

confidence: 89%

“…This suggests that minisatellites are created near telomeres and that their internalisation arises from secondary events resulting from rearrangements involving chromosome ends. Finally, not a single example of an unstable minisatellite with a high ( \1%) mutation rate has yet been reported in the three most thoroughly studied species: pig, rat and mouse [103,104]. More detailed analysis in mice has shown that mutation rates at endogenous murine minisatellites are well below 10 − 4 per generation [104].…”

Section: Minisatellites In Non-human Organismsmentioning

confidence: 90%

“…The use of minisatellites detected by DNA fingerprinting in these various species has been largely restricted to studies of population structure and mating patterns, conservation biology, genetic diversity and the development of genetic markers [99][100][101][102]. The systematic isolation of rat, mouse and pig minisatellites showed that authentic human-like minisatellites do exist in non-primate species [101,103,104], with 10 to 60 bp long GC-rich repeat units and the presence of variant repeat sequences interspersed along the repeat array. In humans, about 90% of minisatellites are localised in subtelomeric regions [103].…”

Section: Minisatellites In Non-human Organismsmentioning

confidence: 98%

“…The systematic isolation of rat, mouse and pig minisatellites showed that authentic human-like minisatellites do exist in non-primate species [101,103,104], with 10 to 60 bp long GC-rich repeat units and the presence of variant repeat sequences interspersed along the repeat array. In humans, about 90% of minisatellites are localised in subtelomeric regions [103]. In contrast, the pig, rat and mouse genomes show lower levels of subtelomeric clustering (66%, 30% and 15%, respectively) [103,104].…”

Section: Minisatellites In Non-human Organismsmentioning

confidence: 99%

See 4 more Smart Citations

Minisatellite instability and germline mutation

Bois

Jeffreys

1999

Cellular and Molecular Life Sciences (CMLS)

View full text Add to dashboard Cite

Tandem-repeat DNA actively turns over in the genome by a variety of poorly understood dynamic mechanisms. Minisatellites, a class of tandem repeats, have been shown to cause disease by influencing gene expression, modifying coding sequences within genes or generating fragile sites. There has been recent rapid progress towards understanding molecular turnover processes at human minisatellites. Instability at GC-rich minisatellites appears to involve distinct mutation processes operating in somatic and germline cells. In the germline, complex conversion-like events occur, probably during meiosis. Repeat turnover appears to be controlled by intense recombinational activity in DNA flanking the repeat array, suggesting that minisatellites might evolve as by-products of localised meiotic recombination in the human genome. In contrast, AT-rich minisatellites appear to evolve by intra-allelic processes such as replication slippage. Curiously, minisatellites in other organisms appear to be more stable than their human counterparts, suggesting species-specific differences in turnover processes. Some yeast models display human-like minisatellite turnover processes at meiosis. However, all attempts to transfer human germline instability to transgenic mice have failed. Finally, tandem repeat instability in various species appears to be extremely sensitive to environmental agents such as radiation via a mechanism which remains enigmatic.

show abstract

Section: Minisatellites In Non-human Organismsmentioning

confidence: 67%

Section: Minisatellites In Non-human Organismsmentioning

confidence: 89%

Section: Minisatellites In Non-human Organismsmentioning

confidence: 90%

Section: Minisatellites In Non-human Organismsmentioning

confidence: 98%

Section: Minisatellites In Non-human Organismsmentioning

confidence: 99%

See 3 more Smart Citations

Minisatellite instability and germline mutation

Bois

Jeffreys

1999

Cellular and Molecular Life Sciences (CMLS)

View full text Add to dashboard Cite

show abstract

Characterization of Kluyveromyces lactis subtelomeric sequences including a distal element with strong purine/pyrimidine strand bias

Nickles

McEachern

2004

Yeast

View full text Add to dashboard Cite

Telomeres are the specialized structures at the ends of eukaryotic chromosomes and are composed of short T/G-rich DNA repeats and the proteins that interact with them. Internal to telomeres are subtelomeric regions that are species-specific and often repetitive. The yeast Kluyveromyces lactis has telomeric tracts of 10-20 copies of a 25 bp repeat, but the subtelomeric regions have not previously been characterized in detail. Here we have cloned and characterized subtelomeric regions from 10 of the 12 chromosome ends. The amount of sequence examined was 0.7-10 kb for each subtelomeric region. We have identified a K. lactis subtelomeric element, the R element, which has a strong purine/pyrimidine strand bias and extends for about 2 kb. Internal to the R element, we found extensive similarity that is shared among half of the chromosome ends reported here. This similarity appears to include three putative gene families, two of which are also subtelomeric in Saccharomyces cerevisiae.

show abstract

Role of transposable elements in the propagation of minisatellites in the rice genome

Inukai

2004

Mol Genet Genomics

View full text Add to dashboard Cite

A survey of minisatellites (MSs) in 5.3 Mb of randomly selected rice DNA sequences from public databases was carried out to clarify the role of transposable elements (TEs) in the dispersal of MSs in the rice genome. The estimated frequency of MSs in this sample was one per 23.4 kb, and this frequency is approximately equivalent to that of Class I microsatellites in the rice genome. Of the MSs in the 5.3-Mb sequence sample, 82% were found to be present in multiple copies in the rice genome, and all of these were a part of TE sequences. In this study at least 61 TE groups were identified as MS carriers. It was also shown that the GC-rich MS pOs6.2H, which was previously reported to be one of the interspersed MSs in the rice genome, is a component of an En/Spm-like element. These results indicate that the majority of MSs in the rice genome are maintained in TEs, and amplified and dispersed as components of the TEs. The G+C content of the multi-locus MS sequences reflected that of the TE sequences containing those MSs, but no obvious bias towards the high G+C content of DNA was observed. Single locus MSs also did not show any obvious bias towards the high G+C content of DNA in the rice genome. In this respect, the MSs in the rice genome are quite different from those in the human genome: in the latter, the majority of MSs show an obvious bias towards the high G+C content of DNA.

show abstract

Analysis of Distribution in the Human, Pig, and Rat Genomes Points toward a General Subtelomeric Origin of Minisatellite Structures

Cited by 13 publications

References 12 publications

Minisatellite instability and germline mutation

Minisatellite instability and germline mutation

Characterization of Kluyveromyces lactis subtelomeric sequences including a distal element with strong purine/pyrimidine strand bias

Role of transposable elements in the propagation of minisatellites in the rice genome

Contact Info

Product

Resources

About