Analysis of effect of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on liver function status of alcohol drinkers in Indonesia

Suhartini, Suhartini; Mustofa, .; Nurhantari, Yudha; Rianto, Bambang Udji Djoko; Widagdo, Hendro; Agni, Idha Arfianti Wira

doi:10.1063/1.5098430

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Previous studies in different ethnicities in Indonesia showed that 72.9% of subjects of Javanese and 35.9% of subjects of Papua ethnicity have at least one polymorphic ALDH2 allele. 9,10 While Java is located in the western part of Indonesia and Papua in the eastern part of Indonesia, there are differences in genetic profile and culture. Despite being in the eastern part of Indonesia, East Nusa Tenggara is known as the melting pot, showing high cultural diversity and evidence of genetic admixture.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Busyra

Nurhantari

Suhartini

et al. 2021

J Community Empowerment for Health

Self Cite

View full text Add to dashboard Cite

Chronic kidney disease is a preventable high-burden disease. Several risk factors for impaired kidney function have been identified, including lifestyles, such as alcohol drinking and cigarette smoking. However, the evidence remains inconsistent. East Nusa Tenggara has the largest proportion of heavy alcohol drinking among all provinces in Indonesia. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) is related to alcohol drinking behavior through the inactivity of the ALDH2 enzyme, which leads to toxic acetaldehyde accumulation. This study aims to recognize the linkage of ALDH2 genotypes to kidney function among alcohol drinkers and cigarette smokers in East Nusa Tenggara. This study was a cross-sectional study of East Nusa Tenggara ethnicity, aged 18-60 years old. Demographic and lifestyle data were obtained via a questionnaire. DNA analysis was conducted with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Creatinine and BUN levels were measured with a chemistry analyzer. Afterward, the estimated glomerular filtration rate (eGFR) was calculated from creatinine value using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The association between kidney function status and alcohol drinking and cigarette smoking habits were analyzed using the chi-square test, then stratified based on genotype groups. Fifty-one subjects were included in this study, while the mean age was 26.33±1.33 years and the median age was 22 years. There were 37 (72.5%) alcohol drinkers and 14 (27.5%) non-drinkers; 28 (54,9%) cigarette smokers and 23 (45.1%) non-smokers. This study revealed no significant association between kidney function status and alcohol drinking habits. Cigarette smoking habits were inversely associated with eGFR decline and creatinine elevation in wild-type ALDH2 groups.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Busyra

Nurhantari

Suhartini

et al. 2021

J Community Empowerment for Health

Self Cite

View full text Add to dashboard Cite

show abstract

Literature Review: Pengaruh Enzim ALDH2 dalam Detoksifikasi Alkohol terhadap Sirosis Hati

Istifara,

Tualeka,

Sillehu

2023

MGK

View full text Add to dashboard Cite

Latar Belakang: Etil alkohol atau disebut juga dengan etanol adalah senyawa organik dan salah satu zat aktif yang sering disalahgunakan oleh masyarakat. Penyalahgunaan alkohol kini menjadi permasalahan global karena menyebabkan berbagai masalah kesehatan. Minuman alkohol memiliki sifat toksik bagi tubuh. Gangguan fungsi hati seperti penyakit hati alkoholik (alcoholic liver disease) timbul sebagai salah satu akibat konsumsi alkohol. Hati yang berperan sebagai pengikat zat-zat kimia (detoksifikasi) akan mengalami pelemakan, sirosis, atau bahkan kerusakan fungsi hati apabila kadar alkohol yang menumpuk dalam hati berlebihan. Tujuan: Studi literatur ini bertujuan untuk menganalisis pengaruh enzim ALDH2 dalam proses detoksifikasi alkohol terhadap penyakit sirosis hati pada pecandu alkohol. Metode: Metode yang digunakan yaitu literature review dari penelitian yang telah dilakukan sebelumnya dengan topik serupa. Artikel diperoleh dari Google Scholar, Science Direct, dan PubMed yang terbit di tahun 2013-2023 dengan menerapkan kriteria inklusi dan eksklusi sehingga diperoleh artikel yang memeneuhi kriteria untuk kemudian dianalisis. Hasil: Hasil literature review dari 5 artikel menunjukkan bahwa enzim ALDH2 berperan dalam proses detoksifikasi alkohol. Enzim ini merupakan enzim pembatas laju metabolisme asetaldehid yang memiliki efek sitotoksik dan karsinogenik. Jumlah alkohol yang berlebih terlebih dengan defisiensi ALDH2 mengakibatkan asetaldehid menumpuk dalam tubuh sehingga meningkatkan resiko terjadinya sirosis hati. Kesimpulan: Kadar ALDH2 pada tubuh memberi pengaruh terhadap terjadinya sirosis hati pada orang yang memiliki kebiasaan minum minuman beralkohol

show abstract

Analysis of effect of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on liver function status of alcohol drinkers in Indonesia

Cited by 2 publications

References 12 publications

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Literature Review: Pengaruh Enzim ALDH2 dalam Detoksifikasi Alkohol terhadap Sirosis Hati

Contact Info

Product

Resources

About