Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas

Cortezzi, Sylvia Sanches; Provazzi, Paola Jocelan Scarin; Sobrinho, João Simão; Mann-Prado, José Carlos; Reis, Patrícia Maria Pizzo; Freitas, Suzy Elaine Nobre de; Filho, José Francisco Góis; Fukuyama, Érica Erina; Cordeiro, José Antônio; Cury, Patrí­cia Maluf; Maniglia, José Vitor; Villa, Luisa L.; Tajara, Eloíza H.; Rahal, Paula

doi:10.1016/j.cancergencyto.2003.07.010

Cited by 33 publications

(36 citation statements)

References 24 publications

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“…Previous studies as well as the present study failed to observe any risk of 2/2 genotype at codon 72 of p53 for the oral cancer and HNSCC. [26][27][28][29][30][31][32][33][34] Thus, it appears that individuals with specific p53 genotypes are more susceptible to the development of tobacco-assisted oral leukoplakia, indicating a possible role of 2/2 variant of p53 codon 72 in early stages of oral cancer development. We speculate that processing of the signals generated from the tobacco-associated DNA damage is differentially regulated depending on both specific p53 variant present and the developmental stage of the incipient tumor.…”

Section: Discussionmentioning

confidence: 99%

“…So far, only a few studies have reported a lack of association of the p53 codon 72 2/2 genotype with susceptibility to head and neck squamous cell carcinoma, [26][27][28][29][30][31][32][33][34] but significant difference in haplotype frequency between head and neck cancer patients and controls has been observed. 32 To date, there is no report on association of a particular p53 genotype and/or haplotype in tobaccoassociated leukoplakia.…”

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confidence: 99%

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Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Mitra

Sikdar

Misra

et al. 2005

Intl Journal of Cancer

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The role of 3 p53 polymorphisms (16 bp duplication at intron 3, codon 72 Arg/Pro and intron 6 NciI RFLP at np 13494) as potential markers for indicating cancer risk remains inconclusive. In our case-control study consisting of 197 leukoplakia and 310 oral squamous cell carcinoma (SCC) patients and 348 controls, genotype frequencies at these 3 p53 loci were determined by PCR-RFLP method and analyzed by multiple logistic regression to determine the risks of the diseases. The 2/2 genotype at codon 72 of p53 was at risk for developing leukoplakia (OR 5 1.6, 95% CI 1.1-2.3), whereas the combination of 1/2 and 2/2 genotypes at intron 3 and 1/1 and 1/2 genotypes at intron 6 conferred a protective effect against leukoplakia and oral SCC development, respectively (OR 5 0.5, 95% CI 0.4-0.8 and OR 5 0.6, 95% CI 0.5-0.9, respectively). When subjects were stratified according to specific tobacco habit, the risk/protection estimates improved significantly in some cases. Specifically, the exclusive smokers with p53 codon 72 2/2 genotype showed a higher risk of developing leukoplakia (OR 5 2.7, 95% CI 1.2-6.3). Furthermore, a particular p53 haplotype 1-2-2 was at risk for both tobacco-associated leukoplakia and oral SCC (OR 5 1.5, 95% CI 1.1-1.9 and OR 5 1.3, 95% CI 1.1-1.7, respectively). Our results show that both specific p53 genotype and haplotype can indicate risk of tobacco-associated leukoplakia, but risk of development of tobacco-associated oral SCC can be predicted by specific p53 haplotype only. ' 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Mitra

Sikdar

Misra

et al. 2005

Intl Journal of Cancer

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“…Shen et al (2002) analyzed oral, pharyngeal, and laryngeal cancer specifically, whereas Ji et al (2008) and Chen et al (2008) studied oropharyngeal cancer as well as oral cancer. Overall, a total of 27 studies consisting of 3966 HNCs cases and 4387 controls were included in our meta-analysis (Yung et al, 1997;Golovleva et al, 1997;McWilliams et al, 2000;Hamel et al, 2000;Summersgill et al, 2000;Tandle et al, 2001;Sourvinos et al, 2001;Nagpal et al, 2002;Shen et al, 2002;Tsai et al, 2002;Tiwawech et al, 2003;Kietthubthew et al, 2003;Katiyar et al, 2003;Scheckenbach et al, 2004;Cortezzi et al, 2004;Hsieh et al, 2005;Sousa et al, 2006;Twu et al, 2006;Hadhri-Guiga et al, 2007;Perrone et al, 2007;Kuroda et al, 2007;Ji et al, 2008;Chen et al, 2007Chen et al, , 2008Lin et al, 2008;Tu et al, 2008;Misra et al, 2009) (Table 2). The genotype distribution of the TP53 Arg72Pro polymorphism is summarized in Table 3.…”

Section: Literature Search Screening and Data Collectionmentioning

confidence: 99%

Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies

et al. 2014

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ABSTRACT. Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association in order to increase understanding of the possible risk factors of HNCs. Twenty-seven casecontrol studies involving 3966 cases and 4387 controls were included in our analysis. Overall, no evidence of association was observed between the TP53 Arg72Pro single nucleotide polymorphism (SNP) and the risk of effects across different subtypes of HNCs. For example, there was a lack of association of this polymorphism with oral cavity cancer, whereas a significant association with nasopharyngeal cancer was observed. Results of this meta-analysis suggest that the TP53 Arg72Pro polymorphism might have different effects on the risk of various subtypes of HNCs.

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“…Nine studies involving 1071 HNSCC cases were included in the meta-analysis (Summersgi ll et al, 2000;Nagpal et al, 2002;Katiyar et al, 2003;Cortezzi et al, 2004;Scheckenbach et al, 2004;Perrone et al, 2007;Hoffmann et al, 2009;Saini et al, 2011;. Figure 1 shows the screening process.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Two studies were from the USA [ethnicity was mixed (white, black, and others; or non-Hispanic white and others)] (Summersgill et al, 2000;, two were from India (Nagpal et al, 2002;Katiyar et al, 2003), one was from Malaysia (Saini et al, 2011), two were from Germany (Scheckenbach et al, 2004;Hoffmann et al, 2009), one was from Italy (Perrone et al, 2007), and one was from Brazil (Cortezzi et al, 2004). The baseline characteristics of the patients are shown in Table 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Xia

Zeng²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas

Cited by 33 publications

References 24 publications

Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

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