Analysis of individual cataract patients and their lenses: A progress report

Clayton, R. M.; Cuthbert, Jennifer A.; Phillips, C I; Bartholomew, R S; Stokoe, N L; Ffytche, T. J.; Reid, J.; Duffy, John C.; Seth, John; Alexander, M.P.H. Melvin

doi:10.1016/s0014-4835(80)80014-5

Cited by 53 publications

(36 citation statements)

References 8 publications

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“…Smith-Lemli-Opitz syndrome, mevalonic acidurias and cerebrotendinous xanthomatosis are genetic defects associated with an increased risk of cataract [12,13]. The mean level of cholesterol in our cataract patients compared with controls was lower, a result also reported by Donnelly et al [7] as well as by Clayton et al [10]. However, in our investigation, this finding was nonsignificant.…”

Section: Discussioncontrasting

confidence: 57%

“…In our subgroups, patients with nuclear-and mixed-type cataract showed a more specific relation between cataract and the level of total protein. Conversely, Clayton et al [10] found significantly lower levels of total protein in cataract patients. In the studies by Donnelly et al [7,9], total protein was significantly lower in cataract groups in their first report, but significantly higher in their second published study.…”

Section: Discussionmentioning

confidence: 92%

“…Thus, blood biochemistry constituents may be associated with various types of cataract as systemic markers [9]. In the first Edinburgh-based study by Clayton et al [10,11], significantly raised levels of bilirubin and glucose were found in cataract patients along with significantly decreased levels of total protein and cholesterol. In addition, Donnelly et al [7] showed the albumin/total protein-albumin ratio to be significant in association with cataract.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Human Age-Related Cataract with Some Blood Biochemistry Constituents

Mirsamadi

Nourmohammadi²

2003

Ophthalmic Res

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Purpose: The causes of age-related cataract are multifactorial and particular consideration has been given to the role of nutritional factors in cataract formation. The purpose of this study was to determine the levels of certain blood biochemistry constituents in cataract patients and controls and evaluate their potential, if any, as identifying risk factors in cataractogenesis. Methods: This is a case-control study where 155 cataract patients and 155 matched controls were chosen for evaluation. Cataract subjects were further divided into subgroups depending on the location of the cataract. All underwent routine eye examinations and blood samples were taken from each one for blood biochemistry analysis including serum levels of glucose, urea, cholesterol, triglycerides, total protein, albumin, bilirubin, calcium, sodium and potassium and the enzymes aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Results: Mean levels of total protein, bilirubin, calcium, sodium, alanine aminotransferase and alkaline phosphatase differed significantly between patient and control groups. Patients with posterior subcapsular cataract had significantly higher glucose levels (p = 0.05) compared with patients with other types of cataract. It was also found that those patients with a cortical cataract had the highest level of urea, differing significantly from other subgroups and controls. Conclusions: The mean levels of all constituents under study fell within normal body range. However, the levels of several important factors demonstrated a positive and significant correlation with cataract. While we do not presume to present these results as conclusive, it is possible that a gradual and constant variation in these parameters may be predisposing factors in cataractogenesis.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Correlation of Human Age-Related Cataract with Some Blood Biochemistry Constituents

Mirsamadi

Nourmohammadi²

2003

Ophthalmic Res

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“…13,14 Lens has high content of potassium and low content of sodium. 15 These two cations are keep in balance with each other mainly due to Na + -K + ATP-ase pump.…”

Section: Discussionmentioning

confidence: 99%

Study of serum sodium and potassium concentration in cataract patients

et al. 2014

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“…However, malabsorption of calcium dramatically enhances the appearance of cataracts associated with idiopathic hypoparathyroidism, and the maintenance of high blood calcium inhibits the development of cataract [1]. Moreover, young chronic renal failure patients who very often have increased calcium-phosphorus product because of 1-·-OH-vitamin D 3 or 24,25(OH) 2 D 3 administration, only very rarely have cataracts, and another factor probably has to coincide [1,2,9,13]. Therefore, chronic hypocalcemia and hyperphosphatemia cannot be exclusively responsible for cataract formation.…”

Section: Discussionmentioning

confidence: 99%

A Rapidly Progressive Cataract in a Patient with Autoimmune Hypoparathyroidism and Acute Liver and Renal Failure

Haviv

Safadi²,

Zamir

1999

Am J Nephrol

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Cataract is a well-known complication of hypoparathyroidism, albeit the mechanism is obscure. The progression of cataract is typically slow in patients with idiopathic hypoparathyroidism. We describe a case of an extremely rapid evolution of typical hypocalcemic cataracts in a patient with familial autoimmune hypoparathyroidism during acute idiopathic hepatic and renal failure, while serum calcium and phosphorus were unbalanced. Physicians and ophthalmologists must be aware of cataracts developing rapidly in the setting of such metabolic derangements.

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Analysis of individual cataract patients and their lenses: A progress report

Cited by 53 publications

References 8 publications

Correlation of Human Age-Related Cataract with Some Blood Biochemistry Constituents

Correlation of Human Age-Related Cataract with Some Blood Biochemistry Constituents

Study of serum sodium and potassium concentration in cataract patients

A Rapidly Progressive Cataract in a Patient with Autoimmune Hypoparathyroidism and Acute Liver and Renal Failure

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