Analysis of maturation of murine dendritic cells (DCs) induced by purified Ganoderma lucidum polysaccharides (GLPs)

Maturation of murine bone marrow dendritic cells induced by acidic Ginseng polysaccharides

“…Therefore they are crucial for the induction of T cell responses that result in cell-mediated immunity. More recently substantial number of articles showed great importance of DCs in both cancer therapy and vaccine preparations [14][15][16]. In this study, we conducted the following exploration to investigate and analyze the changes of murine BMDCs induced by AGP, in order to gain deep understanding of the mechanisms through which AGP regulate immune cells.…”

Phenotypic and functional analysis of the modification of murine bone marrow dendritic cells (BMDCs) induced by neutral Ginseng polysaccharides (NGP)

“…More recently increasing number of articles showed great potential of DCs in both cancer therapy and vaccine preparations. [15][16][17] In this study, we performed the following studies to investigate and analyze the changes of murine BMDCs induced by receptors for uptaking antigens and binding with other cell to trigger an immune response. Great changes on surface of DC will happen while DC goes into maturation.…”

Plant Components for Immune Modulation Targeting Dendritic Cells: Implication for Therapy

“…Polysaccharide GLPs have immunomodulatory, antiangiogenic and cytotoxic activities by affecting the immune cells and immune-related cells including B lymphocytes, T lymphocytes, dendritic cells, macrophages and NK cells [65] Purified GLPs can induce the maturation of murine DCs [66] Antitumor GLPs shows the immunomodulatory, antiangiogenic and cytotoxic activity by affecting the immune cells and immunerelated cells including B lymphocytes, T lymphocytes, DCs, macrophages and NK cells It can induce the production of TNF-α, IL-10, and TGF-β, CD14 + monocyte subpopulation within the PBMCs as well as IL-10 and IL-12 in monocyte-derived dendritic cells [67] Licorice root Osha root, chuchupate, bear medicine, Porter's licorice root A triterpenoid (18β-lycyrrhetinic acid), an aqueous extract of licorice root (glycyrrhizin) Glycyrrhizin increases IL-10 levels by liver dendritic cells in mice with hepatitis [68] 18β-glycyrrhetinic acid could suppress the expression of surface molecules such as CD80, CD86, MHC class I and MHC class II as well as the levels of IL-12 production in polysaccharide-stimulated DCs [69] Antiviral, Antitumor and antiinflammation Glycyrrhizin increases IL-10 levels via liver DCs in mice with hepatitis [70]. For the first time, Bose and his coworkers proposed the antitumor function of NLGP according to its influence on DCs.…”

“…G. lucidum polysaccharides (GLPs) are shown to have a broad range of bioactivities, including anti-inflammatory, hypoglycemic, antiulcer, antitumorigenic and immunostimulating effects [88]. Purified GLPs were shown to induce an effective activation of murine DCs [66]. Both in vitro and in vivo studies showed that the antitumor trait of GLPs are mediated by its immunomodulatory, antiangiogenic and cytotoxic effects.…”

“…Investigations demonstrated the usefulness of G. sinense polysaccharides (especially including the stipes of fruiting bodies) as adjuvant nutrient supplements for patients, receiving immunosuppressive chemotherapies [67]. Several bioactive peptidoglycans have also been extracted from G. lucidum, such as G. lucidum proteoglycan (with antiviral activity), G. lucidum immunomodulating substance, PGY (a water-soluble glycopeptide fractionated and purified from aqueous extracts of G. lucidum fruit bodies), GLPs peptide and F3 (a fucose-containing glycoprotein fraction) [66].…”