Analysis of phase transition and dehydration processes of nevirapine

Oliveira, George Gualberto Gualter de; Ferraz, Humberto Gomes; Severino, Patrícia; Souto, Eliana B.

doi:10.1007/s10973-011-1424-x

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…The development of a new pharmaceutical dosage form involves preliminary pre-formulation studies for which information about the physical, chemical and mechanical properties of the formulation constituents is necessary. Mixture of drug/excipient can affect the long-term stability of the solid dosage form, as well as the drug bioavailability, therapeutic efficiency and safety profile (de Oliveira et al, 2013b, de Oliveira et al, 2011). In addition, the interactions between drug and excipients can affect the quality of the mixture, including the polymorphic form and crystallization profile of the drug, but also the formulation properties such as the solubility of the mixture, color, odor, and taste (Wu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The development of solid dosage forms (e.g. capsules and tablets) for oral administration of drugs for the treatment of flu is an usual practice in commercially available medicines (de Oliveira et al, 2013a, de Oliveira et al, 2011). Examples of drugs are paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) (Palabiyik and Onur, 2010, Samadi-Maybodi and Nejad-Darzi, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Oliveira

Feitosa

Loureiro

et al. 2017

Saudi Pharmaceutical Journal

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Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures

Oliveira

Feitosa

Loureiro

et al. 2017

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…Knowledge about novel pharmaceutical dosage forms is of paramount importance in this context [1][2][3]. Nevirapine is a hydrophobic nonnucleoside reverse transcriptase inhibitor, used in first line regimens of antiretroviral therapy [4,5]. The drug exists in more than one crystalline form, namely the hemiethanolate (form I), hemiacetonitrilate (form II), hemichloroformate (form III), hemi-THF solvate (form IV), mixed hemiethanolate hemihydrate (form V) and hemitoluenate (form VI), reflecting physicochemical changes during production, and this also affects the in vivo performance upon administration [6].…”

Section: Introductionmentioning

confidence: 99%