Analysis of Risk Factors for Secondary New Vertebral Compression Fracture Following Percutaneous Vertebroplasty in Patients with Osteoporosis

Bae, Jung Sik; Park, Jeong Hyun; Kim, Ki Joon; Kim, Hyeun Sung; Jang, Il‐Tae

doi:10.1016/j.wneu.2016.12.038

Cited by 55 publications

(43 citation statements)

References 26 publications

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“…There are many risk factors for non-surgical vertebral fractures in vertebroplasty. Some studies have found that cement intervertebral space leakage is an important influencing factor for new vertebral fractures [2,3] , which is consistent with the conclusions drawn by this study. Sun et al [4] found that if the bone cement is only confined within the trabecular bone range, there is no leakage, the risk of re-fracture of the adjacent vertebral body of the surgical vertebral body is 7%; the cement reaches the endplate level, then the adjacent vertebra The risk of fracture increased to 29%; when the cement reached the level of the intervertebral disc, the risk of an adjacent vertebra fracture increased to about 44%.…”

Section: Discussionsupporting

confidence: 93%

Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Li¹,

Zhang²,

Li³

et al. 2019

ijSciences

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Objective: To analysis the risk factors of nonsurgical vertebral refracture by making retrospectively study about patients with osteoporotic vertebral compression fractures (OVCF) had accepted vertebroplasty.Methods: From June 2016 to December 2017, there were 161 cases of OVCF patients were treated with single-segment vertebroplasty in our department, and follow-up data including age, gender, bone density, bone cement volume, bone cement puncture route, bone cement leakage and vertebral refracture were collected.T-test and chi-square test were used to analyze the possible risk factors for postoperative vertebral refracture.Results: Among 161 patients treated with vertebroplasty, 19 of them had refracture. Among the refracture group, including 2 males and 17 females,bone density (-3.49 + 0.20) in the refracture group, and bone density (-2.95 + 0.57) in the nonrefracture group.The difference was statistically significant (t=-4.162,P<0.001).Eight patients in the refracture group had cement intervertebral leakage, 11 patients in the nonre-fracture group had cement intervertebral leakage,24 patients in the nonre-fracture group had cement intervertebral leakage, and 138 patients in the nonre-fracture group had cement intervertebral leakage. The difference was statistically significant (chi-square = 6.928,P= 0.008).However, there was no statistically significant difference in age, gender, bone cement content, fracture history, surgical method, surgical site, puncture route and other factors.Conclusions: Decreased bone density and intervertebral leakage of bone cement may be risk factors for postoperative nonoperative vertebral refracture. Therefore, reasonable antiosteoporosis treatment should be adhered to, and intervertebral leakage of bone cement should be minimized, to reduce the occurrence of postoperative refracture.

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Section: Discussionsupporting

confidence: 93%

Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Li¹,

Zhang²,

Li³

et al. 2019

ijSciences

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“…In a recent retrospective study of 193 OVCF patients, Bae et al [16] found that 14.6% OVCF patients sustained SVCF after PVP procedures. Compared with the patients who did not experience SVCF, SVCF patients were identified as having poorer bone mineral content and worse bone cement distribution, which can be predictive factors of SVCF.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that long-time menopause and preoperative multi-level vertebral fractures were likely to increase the risk that the patients would suffer from SVCF after PVP surgery, while high bone mineral density (BMD) likely decreased that risk [7]. Bae et al [16] indicated that SVCF that followed PVP surgery was associated with poor bone mineral content and poor distribution of bone cement. Besides, a higher incidence of SVCF may be caused by bone cement leakage into the disc, as compared to non-leakage.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Secondary Vertebral Compression Fracture After Percutaneous Vertebroplasty or Kyphoplasty: A Retrospective Study of 650 Patients

Chen

Ning

et al. 2019

Med Sci Monit

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BackgroundIn this study, we aimed to investigate the risk factors contributing to secondary vertebral compression fractures (SVCF) in patients undergoing percutaneous vertebroplasty (PVP) or kyphoplasty (PKP) due to osteoporotic vertebral compression fracture (OVCF).Material/MethodsBetween January 2010 and December 2017, 650 patients with regular follow-up were identified and retrospectively analyzed in this study. Of these patients, 410 patients underwent PVP and 240 patients underwent PKP surgery. Patients were followed for 24 months on average, ranging from 6 months to 36 months follow-up. Possible risk factors screened for were age, gender, regional distribution, outdoor activity (ODA), bone mineral density (BMD), surgical methods (unilateral or bilateral), bone cement dose, bone cement leakage, chronic disease history, postoperative anti-osteoporosis treatment, and level of preoperative OVCF. Logistic regression analysis was applied to determine potential risk factors.ResultsAs a result, 102 patients (15.7%) suffered SVCF after PVP/PKP surgery at the last follow-up. Binary logistic regression model showed that older age increased the risk of developing SVCF [odds ratio (OR)=2.48, P=0.031] while high-level BMD (OR=0.31, P<0.001) and ODA (OR=0.38, P=0.001) decreased the risk. Binary logistic regression model showed the following: Logit (P)=1.03+0.91X1–1.18X2–0.97X3 (X1=age, OR=2.48, P=0.031; X2=BMD, OR=0.31, P<0.001; X3=ODA, OR=0.38, P=0.001).ConclusionsIn conclusion, older age and lower BMD were identified as risk factors of SVCF for OVCF patients following PVP/PKP surgery, whereas more ODA played a protective role in SVCF development.

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“…[39,40] The study showed that the leakage of bone cement to the intervertebral space increased the risk of fracture of adjacent vertebral body. [35,41] The following mechanism of bone cement leakage may lead to a recurrent fracture of the adjacent [42] hold the point that there is no statistically significant difference in the efficacy and mechanical analysis of PVP by unilateral or bilateral pedicle puncture. VAN-MEIRHAEGHE et al [43]found that the strength and stiffness of injured vertebrae could be restored by unilateral injection or bilateral injection, which had no significant effect on the stress of non-operative vertebral body.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of the Secondary Fractures for Osteoporotic Vertebral Compression Fractures after Percutaneous Vertebroplasty

Kang¹,

Guo²,

Liu³

et al. 2020

Preprint

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Background Percutaneous vertebroplasty related postoperative secondary fractures risk factors were not consistent in patients with osteoporotic vertebral compression Fractures. The purpose was to identify the risk factors of the secondary fractures for osteoporotic vertebral compression fractures after percutaneous vertebroplasty.Methods Potential academic articles were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect and other databases. The time range we retrieved from was that from the inception of electronic databases to August 2019. Gray studies were identified from the references of included literature reports. STATA version 11.0 (Stata Corporation, College Station, Texas, USA) was used to analyze the pooled data.Results Fourteen studies involving 1910 patients, 395 of whom had secondary fracture following the surgery were included in this meta-analysis. The results of meta-analysis showed the risk factors of the secondary fractures for osteoporotic vertebral compression fractures after percutaneous vertebroplasty was related to bone mineral density [WMD= -0.518, 95%CI(-0.784,-0.252), P=0.000], cement leakage [RR=0.596, 95%CI (0.444,0.798), P=0.001] and kyphosis after primary operation [WMD=4.510, 95%CI (3.061,6.004),P=0.000], but not to gender, age, body mass index (BMI), cement volume, thoracolumbar spine, and cement injection approaches.Conclusions BMD, cement leakage and kyphosis after primary operation are the risk factors closely correlative to the secondary fracture after percutaneous vertebroplasty. There has not been enough evidence to support the association between the secondary fracture and gender, age, body mass index, cement volume, thoracolumbar spine, and cement injection approach.

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Analysis of Risk Factors for Secondary New Vertebral Compression Fracture Following Percutaneous Vertebroplasty in Patients with Osteoporosis

Cited by 55 publications

References 26 publications

Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Risk Factors of Secondary Vertebral Compression Fracture After Percutaneous Vertebroplasty or Kyphoplasty: A Retrospective Study of 650 Patients

Risk factors of the Secondary Fractures for Osteoporotic Vertebral Compression Fractures after Percutaneous Vertebroplasty

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