Analysis of sodium 2-mercaptoethane sulfonate in rat plasma using high performance liquid chromatography tandem-mass spectrometry

A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna

“…13,14 In order to obtain optimal chemotherapy results, it is essential to monitor and quantify the level of mesna in patients to regulate its dose. 15 Several methods for the determination of mesna have been reported so far, such as high-performance liquid chromatography (HPLC), 16,17 electrochemical methods, 18 surface-enhanced Raman spectroscopy (SERS), 19 and fluorescence methods. 20,21 Donkor et al developed a rapid and sensitive HPLC-MS/MS method for quantifying mesna in rat plasma, which has a limit of detection (LOD) of 20 nM and showcases a wide linear range (0.05−200 μM).…”

“…20,21 Donkor et al developed a rapid and sensitive HPLC-MS/MS method for quantifying mesna in rat plasma, which has a limit of detection (LOD) of 20 nM and showcases a wide linear range (0.05−200 μM). 16 Verschraagen et al used HPLC with an electrochemical detector equipped with a sensitive wall-injected gold electrode to determine mesna in plasma and urine with a low limit of quantification of 10 nmol/ g. 18 These liquid-chromatography (LC)-based mesna assays are stable and reliable, but time-consuming sample pretreatment and expensive instrumentation prevented their development for point-of-care applications. Zheng et al used an unmodified gold colloid as the probe based on SERS to detect mesna, and its LOD reached 11.6 nM under optimal conditions.…”

“…Several methods for the determination of mesna have been reported so far, such as high-performance liquid chromatography (HPLC), , electrochemical methods, surface-enhanced Raman spectroscopy (SERS), and fluorescence methods. , Donkor et al developed a rapid and sensitive HPLC-MS/MS method for quantifying mesna in rat plasma, which has a limit of detection (LOD) of 20 nM and showcases a wide linear range (0.05–200 μM) . Verschraagen et al used HPLC with an electrochemical detector equipped with a sensitive wall-injected gold electrode to determine mesna in plasma and urine with a low limit of quantification of 10 nmol/g .…”