Analysis of solid cancer incidence risk among the population exposed in the East Urals Radioactive Trace over 1957–2009

Силкин, С. С.; Крестинина, Л. Ю.; Толстых, Е. И.; Епифанова, С. Б.

doi:10.21514/1998-426x-2017-10-1-36-46

Cited by 3 publications

(4 citation statements)

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“…To estimate the potential effect of differences in doses accumulated in bone and colon on the incidence risk value for all solid cancers taken together, we performed the analysis of solid cancer incidence risk excluding cases of bone and colon cancer. The value of ERR/100 mGy obtained in the analysis of 1368 cancer cases with the linear model (with 5-year lag-period) was 0.054 (90% CI: 0.007; 0.107), and did not differ from the one obtained without the exclusion of these sites [27].…”

Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 60%

“…A study of solid cancer incidence risk in the EURTC using doses calculated with unified dosimetry system TRDS showed a significant increase of ERR over 53 years of follow-up [27]. The dose-response relationship was consistent with linearity.…”

Section: Discussionmentioning

confidence: 73%

“…Solid cancer incidence in the EURTC was studied over a 53-year period . The cohort included in the incidence analysis numbered 21 394 persons [27]. The catchment area for the incidence analysis was limited to 5 of 27 administrative-territorial raions of the Chelyabinsk Oblast, Chelyabinsk City and Ozyorsk City, where there was access to malignant neoplasm incidence data.…”

Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 99%

“…It is important to note that neoplasms of unspecified behavior of the brain (ICD-10 code D43) were included in the analysis as the course of this disease was similar to a malignant one. Cancer incidence data by site are provided in table 7 [27].…”

Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 99%

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Consequences of the radiation accident at the Mayak production association in 1957 (the ’Kyshtym Accident’)

2017

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This paper presents an overview of the nuclear accident that occurred at the Mayak Production Association (PA) in the Russian Federation on 29 September 1957, often referred to as 'Kyshtym Accident', when 20 MCi (740 PBq) of radionuclides were released by a chemical explosion in a radioactive waste storage tank. 2 MCi (74 PBq) spread beyond the Mayak PA site to form the East Urals Radioactive Trace (EURT). The paper describes the accident and gives brief characteristics of the efficacy of the implemented protective measures that made it possible to considerably reduce doses to the exposed population. The paper also provides retrospective dosimetry estimates for the members of the EURT Cohort (EURTC) which comprises approximately 21 400 people. During the first two years after the accident a decrease in the group average leukocyte (mainly due to neutrophils and lymphocytes) and thrombocyte count was observed in the population. At later dates an increased excess relative risk of solid cancer incidence and mortality was found in the EURTC.

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Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 60%

Section: Discussionmentioning

confidence: 73%

Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 99%

Section: Assessment Of Radiation Risk Of Solid Cancer Incidence In Eu...mentioning

confidence: 99%

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Consequences of the radiation accident at the Mayak production association in 1957 (the ’Kyshtym Accident’)

2017

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Solid Cancer Incidence Risk among the Population Exposed in the East Urals Radioactive Trace over 1957–2014

Силкин

Krestinina

Аклеев

2020

Medical Radiology and Radiation Safety

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Purpose: Assessment of solid cancer incidence risk in the cohort of exposed population on the territory of the East Urals radioactive trace over the period of follow-up from 1957 to 2014 with the use of the individual doses provided by the latest TRDS dosimetry system. Material and methods: The explosion of the liquid radioactive waste storage tank at the «Mayak» Production Association on 29 September 1957 led to the pollution of the territories of the Chelyabinsk and Sverdlovsk Regions and the formation of the EURT, and the population residing on its territory was subjected to protracted chronic external and internal exposure. The analyzed cohort includes 21,384 people, 2,055 of whom received additional radiation before the 1957 accident due to residing in one of the Techa River settlements. The mean dose to the stomach for the members of the EURT cohort was 36 mGy, the maximum — 1.13 Gy. The analysis was performed using the DATAB and AMFIT programs (statistical software package EPICURE). A simple parametric model of excess relative risk (ERR) was used. Statistical significance and confidence intervals were obtained using the maximum likelihood method. Results: As a result of the analysis of the solid cancer incidence risk in the EURT cohort during the 57-year follow-up period using the linear model and the 5-year latent period, a statistically significant ERR was obtained which equals to 0.052 / 100 mGy (95 % CI 0.01–0.10, p = 0.02) in the entire EURT cohort. When the group of people additionally exposed on the Techa River before the 1957 accident was excluded from the cohort, the risk became insignificant. No significant modification of the dose dependence by non-radiation factors was revealed. The obtained results are compared well with the previous studies of the exposed population in the Southern Urals which were conducted in the Urals Research Center for Radiation Medicine, as well as in the world, devoted to the study of the effects of radiation exposure on population.

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East Ural Radioactive Trace: cancer mortality over a 57-year period (1957-2014)

Silkin,

Krestinina,

Akleyev

2022

Radiac. gig. (2008)

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The objective of the current study was to assess the cancer mortality risk in the cohort of the exposed population on the territory of the East Urals Radioactive Trace over a 57-year follow-up period from 1957 to 2014 using individual doses. Materials and methods: At the end of September 1957 as a result of an accident in the cooling system of storage tanks with liquid radioactive waste, an explosion occurred on the territory of the Mayak PA which led to the formation of the East Urals Radioactive Trace. The population living in the contaminated settlements of the Chelyabinsk and Sverdlovsk regions has been affected by prolonged external and internal exposure. The cohort of individuals exposed in the territory of the East Urals Radioactive Trace numbers 21,384 people, of whom 2,055 persons had lived in Techa riverside settlements before the 1957 accident and received additional radiation exposure. The mean stomach dose for members of the East Urals Radioactive Trace cohort was 36 mGy, the maximum dose was 1130 mGy. The updated TRDS-2016 dosimetry system was used to assess individualized doses. Over the 57-year follow-up period of the cohort (1957-2014), 1294 deaths from cancer were registered in the catchment area. The number of person-years at risk was 511278. The analysis of the cancer mortality risk was carried out with the EPICURE statistical package using the Poisson regression method. Confidence intervals were calculated using the maximum likelihood method. Results: In the course of the cancer mortality analysis in the East Urals Radioactive Trace cohort over a 57-year period, a statistically significant excess relative risk of mortality per 100 mGy equal to 0.05 (95% CI: 0.002; 0.11, p = 0.04) was obtained in the entire East Urals Radioactive Trace cohort. If individuals who received additional exposure on the Techa River were excluded from the analysis, the value of the risk loses its statistical significance.

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Analysis of solid cancer incidence risk among the population exposed in the East Urals Radioactive Trace over 1957–2009

Cited by 3 publications

References 1 publication

Consequences of the radiation accident at the Mayak production association in 1957 (the ’Kyshtym Accident’)

Consequences of the radiation accident at the Mayak production association in 1957 (the ’Kyshtym Accident’)

Solid Cancer Incidence Risk among the Population Exposed in the East Urals Radioactive Trace over 1957–2014

East Ural Radioactive Trace: cancer mortality over a 57-year period (1957-2014)

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