Analysis of solvent effects on polyphenols profile, antiproliferative and antioxidant activities of mulberry (<i>Morus alba</i> L.) extracts

Li, Fuhua; Zhang, Bin; Li, Zhuoshi; Fu, Xiong

doi:10.1111/ijfs.13443

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…The substrate drying was performed in a ventilated incubator, at 40 °C, for 24 h and kept in the dark [ 18 ]. The extraction was realized in Duran bottles (volume 1.00 L; 24 h, at room temperature, stirring 100 rpm) at a concentration of 1% coffee grounds with the solvent: ethanol/water/acetic acid = 50/49.5/0.5 [ 19 ]. Following extraction process, the mixture was filtered (under vacuum) using Whatman filter paper no.…”

Section: Methodsmentioning

confidence: 99%

Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Vamanu

Gatea

Pelinescu

2020

Foods

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Coffee grounds are a valuable source of bioactive compounds. In Romania, most of the amount obtained is lost through non-recovery; the rest is occasionally used as organic fertilizer. The coffee grounds were selected according to the roasting degree: blonde roasted (BR), medium roasted (MR), and dark roasted (DR). The study aimed to evaluate three extracts, obtained with a mixture of ethanol/water/acetic acid (50/49.5/0.5), depending on the roasting degree. The majority phenolic component, the antioxidant, and anti-inflammatory effect, as well as the role that gastrointestinal transit had on the bioavailability of bioactive compounds were determined. Chlorogenic acid was inversely proportional to the roasting degree. BR showed the best correlation between antioxidant and anti-inflammatory activities in vitro/in vivo. The antiproliferative capacity of the extracts determined an inhibitory effect on the tumor cells. Antimicrobial activities, relevant in the control of type 2 diabetes, were exerted through the inhibition of microbial strains (Escherichia coli). Following gastric digestion, BR demonstrated a maximum loss of 20% in the stomach. The recovery of coffee grounds depended on the pattern of functional compounds and the bioavailability of the main component, chlorogenic acid.

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Section: Methodsmentioning

confidence: 99%

Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Vamanu

Gatea

Pelinescu

2020

Foods

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“…Additionally, ultrasound‐assisted extraction has been stated as a valuable green alternative procedure to improve solvent extraction of the bioactive compound (Vega Arroy et al., 2017). As in this study, solvent types have an important effect in determining antioxidant properties and change the results obtained (Li et al., 2017; Ng et al., 2020; Yadav et al, 2016). It was determined in this study that the highest yield was obtained with water extracts.…”

Section: Resultsmentioning

confidence: 80%

Investigation of antioxidant properties of chamomile consumed as herbal tea

Ayhan

2021

J. Food Process. Preserv.

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Common chamomile is consumed as herbal tea due to its antioxidant properties and biological activities in daily life. In this study, antioxidant activities and total phenolic contents of white and yellow chamomiles were investigated in terms of extraction methods and solvent types. In all extraction methods used for extraction of both chamomiles, the best antioxidant activity and total phenolic results were obtained with water extracts. Also, the best yield was found with sonication‐assisted stirring for both chamomile extracts obtained using three extraction solvents. DPPH and ABTS radical scavenging activities obtained by sonication‐assisted stirring for water extracts were 10.886 ± 0.244 mg TEAC/g and 8.702 ± 0.567 mg TEAC/g for white chamomile, and 11.709 ± 0.693 mg TEAC/g and 11.139 ± 0.514 mg TEAC/g for yellow chamomile. The total phenolic contents were determined as 3.863 ± 0.325 mg GAE/g for white chamomile and 5.225 ± 0.417 mg GAE/g for yellow chamomile. Novelty impact statement In this study, the antioxidant properties of white and yellow chamomile were examined in detail in terms of different extraction methods and solvent types. Sonication‐assisted stirring and water were determined to be the best extraction method and solvent for both chamomiles. According to the results, it can be stated that chamomile has higher antioxidant properties than white chamomile under the best extraction conditions.

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“…Recently, researchers have focused on extracting bioactive components from mulberry using SLE, showcasing its potential [106]. Various studies explored the impact of extraction solvent on M. alba fruit polyphenols' profile and their antioxidant properties against human hepatoma HepG2 cells [107]. A separate study investigated the effect of various factors on the yield of M. alba leaf polysaccharides, finding that optimal conditions led to enhanced solubility and yield [63].…”

Section: Solid-liquid Extraction (Sle)mentioning

confidence: 99%

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

Abbas,

Tong,

Wang

et al. 2024

IJMS

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Mulberry is a rapidly growing plant that thrives in diverse climatic, topographical, and soil types, spanning temperature and temperate countries. Mulberry plants are valued as functional foods for their abundant chemical composition, serving as a significant reservoir of bioactive compounds like proteins, polysaccharides, phenolics, and flavonoids. Moreover, these compounds displayed potent antioxidant activity by scavenging free radicals, inhibiting reactive oxygen species generation, and restoring elevated nitric oxide production induced by LPS stimulation through the downregulation of inducible NO synthase expression. Active components like oxyresveratrol found in Morus demonstrated anti-inflammatory effects by inhibiting leukocyte migration through the MEK/ERK signaling pathway. Gallic and chlorogenic acids in mulberry leaves (ML) powder-modulated TNF, IL-6, and IRS1 proteins, improving various inflammatory conditions by immune system modulation. As we delve deeper into understanding its anti-inflammatory potential and how it works therapeutically, it is crucial to refine the extraction process to enhance the effectiveness of its bioactive elements. Recent advancements in extraction techniques, such as solid–liquid extraction, pressurized liquid extraction, superficial fluid extraction, microwave-assisted extraction, and ultrasonic-assisted extraction, are being explored. Among the extraction methods tested, including Soxhlet extraction, maceration, and ultrasound-assisted extraction (UAE), UAE demonstrated superior efficiency in extracting bioactive compounds from mulberry leaves. Overall, this comprehensive review sheds light on the potential of mulberry as a natural immunomodulatory agent and provides insights into its mechanisms of action for future research and therapeutic applications.

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Analysis of solvent effects on polyphenols profile, antiproliferative and antioxidant activities of mulberry (Morus alba L.) extracts

Cited by 9 publications

References 41 publications

Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Investigation of antioxidant properties of chamomile consumed as herbal tea

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

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