Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study

Rostkowska, Olga; Kuthan, Robert; Burban, Anna; Salińska, Jagoda; Ciebiera, Michał; Młynarczyk, G.; Durlik, Magdalena

doi:10.3390/antibiotics9060284

Cited by 9 publications

(12 citation statements)

References 34 publications

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“…Overall, we observed high prevalence of virulence factors common in UTIs in different geographic areas, i.e., gelatinase ( gelE ) and adhesins ( efaA , esp ), that facilitate colonization of urothelial cells, biofilm formation and exchange of genetic material, tissue damage, and resistance to some bioactive peptides [ 28 , 29 , 30 , 31 ]. Antibiotic sensitivity was in a similar range as other studies conducted on E. faecalis isolated from UTIs, with the highest sensitivity to β-lactams, glycopeptides, linezolid, and fosfomycin and intermediate susceptibility to aminoglycosides or streptomycin [ 32 , 33 , 34 ]. Remarkably, there was not a correlation between virulence factors and antibiotic resistance among the clinical isolates ( Tables S1 and S2 ).…”

Section: Discussionsupporting

confidence: 68%

Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci

et al. 2020

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The genus Enterococcus comprises a ubiquitous group of Gram-positive bacteria that can cause diverse health care-associated infections. Their genome plasticity enables easy acquisition of virulence factors as well as antibiotic resistances. Urinary tract infections (UTIs) and catheter-associated UTIs are common diseases caused by enterococci. In this study, Enterococcus strains isolated from UTIs were characterized, showing that the majority were E. faecalis and contained several virulence factors associated to a better colonization of the urinary tract. Their susceptibility against the bacteriocin AS-48 and several antibiotics was tested. AS-48 is a potent circular bacteriocin that causes bacterial death by pore formation in the cell membrane. The interest of this bacteriocin is based on the potent inhibitory activity, the high stability against environmental conditions, and the low toxicity. AS-48 was active at concentrations below 10 mg/L even against antibiotic-resistant strains, whereas these strains showed resistance to, at least, seven of the 20 antibiotics tested. Moreover, the effect of AS-48 combined with antibiotics commonly used to treat UTIs was largely synergistic (with up to 100-fold MIC reduction) and only occasionally additive. These data suggest AS-48 as a potential novel drug to deal with or prevent enterococcal infections.

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Section: Discussionsupporting

confidence: 68%

Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci

et al. 2020

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“…The results also showed an increase in the number of Gram-positive uropathogens especially Enterococcus faecalis and Enterococcus facium. Several previous studies showed the emergence of non-Enterobacteriaceae, i.e., Enterococcus faecalis and Enterococcus facium as primary causative agents for urinary tract infections (Parameswarappa et al 2013;Shrestha et al 2019;Rostkowska et al 2020). Therefore, Enterococcus faecalis and Enterococcus facium are projected in contributing to the rapid increase of multidrug resistance due to their intrinsic resistance plus genetic diversity, including resistance to the well-known synthetic drugs to prevent urinary tract infections such as nitrofurantoin (Zhang et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Species distribution of Enterobacteriaceae and non-Enterobacteriaceae responsible for urinary tract infections at the Zainoel Abidin Hospital in Banda Aceh, Indonesia

et al. 2021

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Abstract. Suhartono S, Mahdani W, Hayati Z, Nurhalimah N. 2021. Species distribution of Enterobacteriaceae and non-Enterobacteriaceae responsible for urinary tract infections at the Zainoel Abidin Hospital in Banda Aceh, Indonesia. Biodiversitas 22: 3313-3318. Urinary tract infection (UTI) is an infection that occurs along the urinary tract caused by pathogenic bacteria. Enterobacteriaceae and non-Enterobacteriaceae are generally normal flora originating from the large intestine and vaginal mucosa. This study aimed to assess the distribution of Enterobacteriaceae and non -Enterobacteriaceae pathogens that cause UTI based on species diversity, patient age, gender, and hospital units, and to evaluate their antibiotic sensitivity to uropathogens in ZAH. In total, there were 284 isolates classified as UTI pathogens with 178 Enterobacteriaceae isolates dominated by Escherichia coli and 107 non- Enterobacteriaceae isolates. Non- Enterobacteriaceae consisted of 77 isolates of Gram-positive dominated by Enterococcus faecalis and Enterococcus facium, and 29 isolates of Gram-negative dominated by Acinetobacter baumannii. The highest UTI ratio was found in the elderly (56-65 years), namely 66.2% Enterobacteriaceae and 33.8% non-Enterobacteriaceae isolates. Based on gender, females were infected with Enterobacteriaceae (66.86%) and non-Enterobacteriaceae (37.41%). Most of UTI patients in the internal medicine unit were infected with Enterobacteriaceae (55.36%) and non-Enterobacteriaceae (44.64%). Amikacin, meropenem, and levofloxacin were antibiotics that had high sensitivity against Enterobacterial and non-Enterobacterial uropathogens. The emergence of Gram-positive uropathogens need to be concerned as these groups start emerging. It is also important to monitor regularly the antibiotic susceptibility of bacterial UTI pathogens to ensure the efficacy of current UTI treatments and minimize the UTI incidence in nosocomial settings.

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“…Statistical data on uropathogens causing UTIs in kidney transplant recipients presented by four groups of Polish authors showed different results depending on the transplant centre in Poland ( Gołębiewska et al., 2011 ; Adamska et al., 2015 ; Gozdowska et al., 2016 ; Rostkowska et al., 2020 ). Furthermore, the results from the same centre but from different study periods also varied.…”

Section: Epidemiology Of K Pneumoniae Uti In Kidne...mentioning

confidence: 99%

Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance

Krawczyk

Wysocka

Michalik³

et al. 2022

Front. Cell. Infect. Microbiol.

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Urinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient’s death. K. pneumoniae has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk factors associated with urinary tract infections in kidney transplant recipients, multi-drug resistance of K. pneumoniae (ESBL, KPC, NDM), treatment and pathogenesis of K. pneumoniae infections, and possible causes of recurrent UTIs. It also addresses the issue of colonization/becoming a carrier of K. pneumoniae in the gastrointestinal tract and asymptomatic bacteriuria in relation to a symptomatic UTI development and epidemiology.

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Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study

Cited by 9 publications

References 34 publications

Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci

Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci

Species distribution of Enterobacteriaceae and non-Enterobacteriaceae responsible for urinary tract infections at the Zainoel Abidin Hospital in Banda Aceh, Indonesia

Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance

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