Analysis of the <i>PPARD</i> gene expression level changes in football players in response to the training cycle

Domańska-Senderowska, Daria; Snochowska, Aleksandra; Szmigielska, Paulina; Jastrzębski, Zbigniew; Jegier, Anna; Kiszałkiewicz, Justyna; Dróbka, K; Jastrzębska, Joanna; Pastuszak-Lewandoska, Dorota; Maciejewska-Skrendo, Agnieszka; Żmijewski, Piotr; Brzeziańska-Lasota, Ewa

doi:10.2478/bjmg-2018-0008

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Firstly PPARD is a regulatory factor for the expression of enzymes needed in fat metabolism, which enhances the activity of PPARD to increase the expression of various enzymes, thus increasing fat metabolism and energy consumption [24]. Secondly, PPARD regulates the body's fat metabolism and is a sensor of plasma-free fatty acids in the liver [25]. Thirdly, PPARD is closely related to fat metabolism and cell proliferation, cell differentiation, migration, apoptosis, and in ammation.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids

Yong

Wang

et al. 2021

Preprint

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Background：The Gelsemium elegans alkaloids have been used in animal feed additives and already achieved terrific results in the pig’s gut health and weight gain. A series of studies have been conducted to explore the mechanisms by which it improves gut health and promotes growth. However, hardly any research has been done in the metabolic changes G. elegans alkaloids elicit in pork muscle. Angiopoietin-like 4 (ANGPTL4), an inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance, is transcribed at a higher rate relative to others in G. elegans alkaloids non-feeding muscle than in G. elegans alkaloids feeding muscle.Methods：A total of 24 muscle tissues and corresponding blood samples were collected from pigs and Target RNA was extracted using TRIzol reagent according to the manufacturer's instructions. Histological and immunofluorescence analysis combined with Western blot analysis were utilized to further explore the possible mechanism of ANGPTL4 and peroxisome proliferator-activated receptor-δ(PPARD).Results： This phenomenon results from that ANGPTL4 in G. elegans alkaloids non-feeding muscle is mediated by elevated plasma free fatty acids via PPARD, presumably leading to reduced local uptake of plasma triglyceride-derived fatty acids and their sparing for use by feeding with G. elegans alkaloids. In contrast, the transcription of ANGPTL4 in G. elegans alkaloids feeding muscle likely is counteracted via lipoprotein lipase(LPL)-mediated negative-regulation, promoting the use of plasma triglycerides as fuel for active muscles. Conclusion：The experimental result indicates that the muscle and the local regulation of ANGPTL4 via PPARD and LPL have critical roles in governing lipid homeostasis during the feeding process of pigs and will shed light on the molecular mechanism discovered by G. elegans alkaloids.

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Section: Discussionmentioning

confidence: 99%

Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids

Yong

Wang

et al. 2021

Preprint

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“…Mice studies suggested that PPARδ plays an important role in myelination of the corpus callosum, cell differentiation, epidermal cell proliferation, and lipid metabolism [20–22]. Functional studies suggested that the PPARD gene was involved in muscle development and adaptive response to fitness training [23–26]. In mice skeletal muscle, targeted expression of activated PPARδ triggered adaptation from type 2 muscle fibers to type 1 muscle fibers [27].…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children

et al. 2019

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Background Athletic performances are complex traits with heritability of ~66%. Dynamic balance is one of the most important athletic performances, and there has been little studies for it in sports genomics. The candidate PPARD gene was reported to be able to affect muscle development for balance predisposition and influence the athletic performance including skiing triumph in the Caucasian population. This study aims to investigate whether the PPARD gene is a susceptibility gene for dynamic balance performance in Han Chinese children. Results A total 2244 children were recruited and their balance beam performances were measured. Five polymorphisms in the PPARD gene were genotyped through the MassARRAY Sequenom platform. Rs2016520 exerted significant association with dynamic balance performance (minor allele C, P = 0.015, P corrected < 0.05) and was affirmed in a meta-analysis by combining previously reported Caucasian cohorts (OR = 1.57, 95% CI = [1.30, 1.91], P < 10 -5 ) . Another polymorphism, rs2267668, was also significantly associated with dynamic balance performance (minor allele G, P = 0.015, P corrected < 0.05). In the dichotomous study, 321 cases (61% boys and 39% girls) and 370 controls (49% boys and 51% girls) in our samples were selected as representatives, and the thresholds were the mean velocity (0.737 m/s) ± standard deviation (0.264 m/s), in which rs2016520-C and rs2267668-G still remained significant (CI =1.41 [1.11~1.79], P = 0.004, P corrected < 0.016; CI =1.45 [1.14~1.86], P = 0.002, P corrected < 0.016). In different genders, consistent OR direction was observed for each variant. Conclusions Our results suggested that the PPARD gene is associated with dynamic balance performance of human being, and further studies to reveal its etiology is strongly suggested. Electronic supplementary material The online version of this article (10.1186/s41065-019-0092-x) contains supplementary material, which is available to authorized users.

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Genetic association research in football: A systematic review

McAuley

Hughes

Tsaprouni

et al. 2020

European Journal of Sport Science

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Genetic variation is responsible for a large amount of the inter-individual performance disparities seen in sport. As such, in the last ten years genetic association studies have become more common; with one of the most frequently researched sports being football. However, the progress and methodological rigor of genetic association research in football is yet to be evaluated. Therefore, the aim of this paper was to identify and evaluate all genetic association studies involving football players and outline where and how future research should be directed.Firstly, a systematic search was conducted in the Pubmed and SPORTDiscus databases, which identified 80 eligible studies. Progression analysis revealed that 103 distinct genes have been investigated across multiple disciplines; however, research has predominately focused on the association of the ACTN3 or ACE gene. Furthermore, 55% of the total studies have been published within the last four years; showcasing that genetic association research in football is increasing at a substantial rate. However, there are several methodological inconsistencies which hinder research implications, such as; inadequate description or omission of ethnicity and onfield positions. Furthermore, there is a limited amount of research on several key areas crucial to footballing performance, in particular; psychological related traits. Moving forward, improved research designs, larger sample sizes, and the utilisation of genome-wide and polygenic profiling approaches are recommended. Finally, we introduce the Football Gene Project, which aims to address several of these limitations and ultimately facilitate greater individualised athlete development within football.

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Analysis of the PPARD gene expression level changes in football players in response to the training cycle

Cited by 3 publications

References 40 publications

Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids

Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids

Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children

Genetic association research in football: A systematic review

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