Human skin is the biggest organ in the body, which has a lot of characteristics and fundamental functions. On one hand, skin directly contacts the environment and can be influenced by chronological ages and environment changes, like humidity and temperature.On the other hand, skin can protect from Ultraviolet light. Skin is smooth, while the surface is not even due to the skin micro-relief, which is a pattern of the network consisting of furrows, polygonal forms, and pores. (Figure 1). Skin micro-relief is one of the most important parameters of skin when mentioned in skin condition assessment and skin detection.According to previous research, there are two main methods to evaluate skin micro-relief, which is using replica to get a copy of skin micro-relief, or using non-invasive devices to take the twodimensional or three-dimensional images of skin micro-relief, like microscopy. These methods have their own merits. The replica can get the real and integrated topography of skin micro-relief, but it needs