Analysis of the proteins in human seminal plasma

Quinlivan, W. Leslie G.

doi:10.1016/0003-9861(68)90278-6

Cited by 28 publications

(10 citation statements)

References 8 publications

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“…1). Almost identical distribution curves for spermatozoa and fructose were obtained by Harvey (1956 The presence of IgG, albumin and transferrin in semen has been described previously, although these proteins have never been examined in split ejaculates (Goldblatt, 1935;Gray & Huggins, 1942;Hermann, 1959;Licht & Keutel, 1963;Quinlivan, 1968). Traces of IgA have been reported (Herrmann & Hermann, 1969b) This indicates that lactoferrin is secreted in the vesicular glands (Hekman & Rümke, 1968).…”

Section: Transferrin and Albuminmentioning

confidence: 52%

“…Transferrin is the iron-binding protein in serum and its presence in semen was first described by Quinlivan (1968). Transferrin may have similar functions to those of lactoferrin in the reproductive tract, i.e.…”

Section: Transferrin and Albuminmentioning

confidence: 99%

“…protection against bacterial infection. The concentration of transferrin in semen is approximately one-third ofthat in serum, but is eight to ten times higher than in cervical mucus where it shows increasing levels in the late luteal phase and exhibits a peak shortly after the menstruation (Quinlivan, 1968;Herrmann & Hermann, 1969a, b . The IgG:IgA ratio was calculated to be between 2:1 and 3:1 for all split-ejaculate fractions and for the total concentration.…”

Section: Transferrin and Albuminmentioning

confidence: 99%

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Components of Human Split Ejaculates

Tauber¹,

Zaneveld²,

Propping³

et al. 1975

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160

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Summary. The concentrations of spermatozoa, fructose, IgG, IgA, albumin, lactoferrin, transferrin, secretory piece of IgA, \ g=b\ 1C/ \ g=b\ 1A\ x=r eq-\ globulin (C\m='\3-component of complement), ceruloplasmin and fibrinogen were evaluated in human split ejaculates and/or in whole human seminal plasma. The concentrations of spermatozoa, IgG, IgA, albumin and transferrin decreased from the first portion of the split ejaculate to the last, indicating that these proteins originate mostly from secretions other than the seminal vesicles. By contrast, the highest amounts of fructose and lactoferrin were present in the final portion of the split ejaculates, showing their seminal vesicle origin. No secretory piece, IgM, \ g=b\ 1C/ \ g=b\ 1A\ x=r eq-\ globulin, ceruloplasmin or fibrinogen could be detected in human semen. An unidentified antigen was found that has a relatively high molecular weight and shows \g=b\1-mobility on immunoelectrophoresis.

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Section: Transferrin and Albuminmentioning

confidence: 52%

Section: Transferrin and Albuminmentioning

confidence: 99%

Section: Transferrin and Albuminmentioning

confidence: 99%

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Components of Human Split Ejaculates

Tauber¹,

Zaneveld²,

Propping³

et al. 1975

Reproduction

160

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“…Li and Beling (1973) observed 12 precipitation lines by immunoelectrophoresis with rabbit anti-SP. Quinlivan (1968) separated seminal plasma into 15 protein bands by PGDE. In this experiment, 14 precipitation lines which divided into three major groups were developed with anti-SP, suggesting that crossed immunoelectrophoresis could separate SP to the same extent as PGDE.…”

Section: Resultsmentioning

confidence: 99%

Individual difference of seminal plasma detected with crossed immunoelectrophoresis.

Iwasa

Yokoi

Sagisaka

1983

Tohoku J. Exp. Med.

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“…Besides these 'organ-specific' proteins, human seminal plasma is rich in other proteins, most of which have been clearly identified with electrophoretic techniques (Quinlivan, 1968;Edwards et al, 1981): albumin, lactoferrin, IgA, IgG, fibrinogen, prealbumin, trypsin and several other enzymes. For some of them, their origin as well as their role inside the male genital tract remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Immunologically reactive albumin-like protein in human testis and seminal plasma

Orlando¹,

Casano²,

Forti³

et al. 1988

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An immunologically reactive albumin-like protein (albumin) was localized, by an immunostaining technique, in the testis of infertile men (normal spermatogenesis, obstructive azoospermia) at the level of the Sertoli cells and in some cells of the germinal epithelium (secondary spermatocytes and early spermatids). No positive reaction was detectable in prepubertal testis. In vasectomized men, mean seminal albumin values were drastically reduced (by about 80%) in comparison to fertile controls, indicating a probable testicular origin. Mean seminal albumin values were also decreased in patients affected by azoospermia due to a seminiferous tubular lesion (about 40%) and in oligozoospermic patients (about 30%). In the same seminal samples transferrin, an index of Sertoli cell function, was also measured. Albumin and transferrin results were well correlated in the seminal plasma of each group (with the exception of vasectomized subjects), including a group of men with abnormally high concentrations of seminal transferrin. A weak correlation was found between seminal albumin and sperm count. We suggest that the presence of albumin in the human adult testis and in seminal plasma could be related to its ability to transport androgens.

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Analysis of the proteins in human seminal plasma

Cited by 28 publications

References 8 publications

Components of Human Split Ejaculates

Components of Human Split Ejaculates

Individual difference of seminal plasma detected with crossed immunoelectrophoresis.

Immunologically reactive albumin-like protein in human testis and seminal plasma

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