Analysis of the serum components in acute period after subarachnoid hemorrhage

Abstract

AIm: Multi-profile monitoring of various blood serum factors during acute subarachnoid haemorrhage (SAH) is crucial for successful treatment. The aim of the study is to evaluate the serum concentration of different blood factors in the acute period of SAH. mATERIAL and mETHods: 31 patients with confirmed aneurysmal SAH were enrolled in a prospective study. The concentrations of the following serum compounds were assessed on the day of admission and reassessed after 5 days: lipids profile, cardiac functionality enzymes and markers, electrolytes, osmolality, CRP (C-reactive protein), glucose, creatinine, urine. REsuLTs:The mean level of high-density lipoprotein (HDL) changed significantly from 43.9±23.9 mg/dL to 27.5±19,8 mg/dL, p=0,013 (mean dif. 16.5±14,1 mg/dL; 37,3%). Concentration of low-density lipoprotein (LDL) decreased by 28.6% (mean dif. 26.78±61.32; p=0.047). Values of triglicerydes and total cholesterol did not differ significantly between the initial evaluations and these repeated after 5 days. The overall serum ions (Na) concentrations and osmolality did not differ significantly between the initial measurements and after 5 days from SAH. The only mean value that appeared to be substantially increased at initial measurement was NT-proBNP and reached 1928.8±4952 pg/ ml, this value dropped down to 392.87±1147.9 mg/ml after 5 days (mean dif. 1535.96±4808.76 pg/ml; 79,6%; p = 0.247). CRP increased over 2 fold after 5 days up to 29.267±28.614 mg/L (mean dif. 16.06±34.05 pg/L; 121.6%; p=0.028). At 5-day follow up hematocrit dropped to 33.38 ± 3.81% from the initial value of 39.63 ± 2,56% (p=0.02). CoNCLusIoN:This study showed a significant decrease in the serum level of LDL and HDL, while triglycerides were moderately heightened. Routine monitoring of lipid profile and statin administration at the early stage of SAH is recommended.KEywoRds: Subarachnoid haemorrhage, Aneurysm, Lipids, Electrolytes, Cardiac enzymes ÖZ AmAÇ: Akut subaraknoid kanama (SAK) sırasında çeşitli kan serumu faktörlerinin çoklu profille izlenmesi başarılı bir tedavi için çok önemlidir. Çalışmanın amacı, SAK'nın akut döneminde farklı kan faktörlerinin serum konsantrasyonunu değerlendirmektir. yÖNTEm ve GEREÇLER: Bu prospektif çalışmaya teyit edilmiş anevrizmal SAK durumu olan 31 hasta alındı. Aşağıdaki serum bileşiklerin konsantrasyonları hastaneye yatma gününde ve 5 gün sonra değerlendirildi: lipid profili, kardiyak fonksiyon enzimleri ve belirteçleri, elektrolitler, ozmolalite, CRP (C-reaktif protein), glukoz, kreatinin. Ayrıca idrar tahlili yapıldı.BuLGuLAR: Yüksek dansiteli lipoprotein (HDL) ortalama seviyesi 43,9±23,9 mg/dL'den 27,5±19,8 mg/dL'ye önemli ölçüde değişti ( p=0,013) (ortalama fark 16,5±14,1 mg/dL; %37,3). Düşük yoğunluklu lipoprotein (LDL) konsantrasyonu %28,6 düştü (ortalama fark 26,78±61,32; p=0,047). Trigliserid ve total kolesterol değerleri açısından ilk değerlendirme ve 5 gün sonra tekrarlananlar arasında anlamlı farklılık yoktu. Genel serum iyon (Na) konsantrasyonları ve ozmolalite açısından ilk değerlend...

Clinical significance of changes in IL-6, CRP and S100 in serum and NO in cerebrospinal fluid in subarachnoid hemorrhage and prognosis

“…SAH is a clinical syndrome caused by many factors with a high mortality rate, which refers to the blood reaching the intracranial or intraspinal subarachnoid space after intracranial vascular rupture ( 11 , 12 ). IL-6, as a kind of glycoprotein, can participate in the collective inflammatory response and anti-infective defense mechanisms ( 13 , 14 ).…”