Clinical significance of changes in IL-6, CRP and S100 in serum and NO in cerebrospinal fluid in subarachnoid hemorrhage and prognosis

Abstract

Clinical significance of changes in interleukin-6 (IL-6), C-reactive protein (CRP) and S100 in serum and NO was investigated in cerebrospinal fluid (CSF) in subarachnoid hemorrhage (SAH) and its prognosis. A total of 43 SAH patients and 23 healthy subjects were selected and divided into cerebral vasospasm (CVS) group and non-CVS group, and favorable prognosis group and unfavorable prognosis group according to Hunt-Hess grade. The levels of IL-6, CRP, S100 and NO in CSF were detected, respectively, followed by statistical analysis of correlation. The higher the Hunt grade was, the higher the factor expression was; the expression levels of IL-6, CRP, S100 and NO in CSF were gradually increased in CVS group and unfavorable prognosis group, and the differences were significant compared with those in the control group. There was a positive correlation between the expression levels of each of the two factors among IL-6, CRP, S100 and NO in CSF, and the differences were statistically significant (P<0.05). The expression levels of IL-6, CRP, S100 and NO in CSF in SAH patients are significantly increased, showing positive correlations and participating in the occurrence and development of SAH, which provide new directions for the early clinical diagnosis of SAH.

Increased interleukin-6 levels in neuron-derived plasma small extracellular vesicles in patients with aneurysmal subarachnoid hemorrhage

“…Several inflammatory cytokines have been found to be linked to aSAH [21]. IL-6 plays an important role in brain injury, and associated with aSAH in numerous studies [23,26,30]. A previous study showed that IL-6 in cerebrospinal fluid (CSF) was a biomarker for predicting vasospasm after SAH [31].…”

“…Yet another study showed that IL-6 in CSF could be a useful diagnostic tool for predicting shunt dependency in aSAH patients with acute hydrocephalus [33]. Serum IL-6 levels were elevated, and were associated with prognosis in aSAH patients [26,34]. However, many previous studies also showed that determining the IL-6 levels in blood circulation may not be sufficient [30,35].…”

“…IL-6 is a proinflammatory cytokine, levels of which elevate in response to acute brain injury and other diseases [17,24,25]. Several studies have demonstrated that elevated IL-6 levels induce neuroinflammation and may be closely associated with the prognosis of aSAH [23,26,27] .…”

Increased Interleukin-6 Levels in Neuron-Derived Plasma Small Extracellular Vesicles of Subarachnoid Haemorrhage Patients

“…Several in ammatory cytokines have been found to be linked to aSAH [21]. As a well-known cytokine, IL-6 play an important role in brain injury, and associated with aSAH in numerous studies [23,26,30]. Previous study showed that IL-6 in cerebrospinal uid (CSF) seem to be a biomarker for predicting vasospasm after SAH [31].…”

“…IL-6 is a proin ammatory cytokine in response to acute brain injury and other diseases [17,24,25]. Several studies have demonstrated elevated IL-6 levels may induce neuroin ammation and may be closely associated with the prognosis of aSAH patients [23,26,27].…”