Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system

Chang, Ji‐Eun; Lee, Dae Sik; Ban, Sang Woo; Oh, Jee Young; Jung, Moon Youn; Kim, Seunghwan; Park, Sung‐Joon; Persaud, Krishna; Jheon, Sanghoon

doi:10.1016/j.snb.2017.08.057

Cited by 126 publications

(80 citation statements)

References 42 publications

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“…Such measurements can be performed with thermal desorption gas chromatography mass spectrometry (TD-GC-MS), where a sample is placed in a closed vessel. The sample is then heated to encourage the production of volatiles and the headspace is captured for analysis by GC-MS. Investigation of volatile metabolites using mass spectrometry has proven to be extremely useful in clinical studies (10)(11)(12)(13) as well as in the analysis of the consistency and provenance of edible items (14)(15)(16).…”

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confidence: 99%

Discovery of volatile biomarkers of Parkinson’s disease from sebum

Trivedi

Sinclair

et al. 2018

Preprint

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Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic test (1-3). We have serendipitously identified a hyperosmic individual, a 'Super Smeller' that can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects(4). Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort, identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our 'Super Smeller'.Physicians in ancient times, including Hippocrates, Galenus, and Avicenna, used odor as a diagnostic tool. Although the olfactory skills of physicians are not routinely used in modern medicine, it is well documented that a number of conditions, predominantly metabolic and infectious diseases, are associated with a unique odor(5), but there is scant evidence for odors as symptoms of neurodegenerative disorders. Joy Milne, a Super Smeller whose Recently, TD-GC-MS has been used as a volatilome analysis platform for the detection of compounds from bacteria implicated in ventilator associated pneumonia(12), for differentiation between odors due to human and animal decomposition(17), as well as aerosol detection of the fumes from e-cigarettes(18). This versatility of TD-GC-MS for samples from many sources renders it highly suitable for use in identifying the metabolites

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confidence: 99%

Discovery of volatile biomarkers of Parkinson’s disease from sebum

Trivedi

Sinclair

et al. 2018

Preprint

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“…Nevertheless, more subjects are needed in order to increase the sensitivity and negative predictive value (69). Chang et al (11) examined the breath samples of 37 patients with LC and 48 healthy controls using a sensor system, which was found to have 79.0% sensitivity and 72.0% specificity. Gasparri et al (70) reported the differentiation of 70 patients with LC from 76 healthy controls with 81% sensitivity and 91% specificity, using a gas sensor array composed of a matrix of eight quartz microbalances.…”

Section: Emerging Non-invasive Detection Methods For Lcmentioning

confidence: 99%

“…Recent advances in the field of VOC biomarkers have improved the sensitivity and specificity in the diagnosis of LC (10). A VOC pattern or specific VOCs can be detected and used as a potential guide for the development of effective therapeutics (11). The use of mass spectrometers or sensors for the precise detection of volatile biomarkers could substantially aid the diagnostic process by supplementing the standard screening methods in the early diagnosis and prognosis of patients with LC.…”

Section: Introductionmentioning

confidence: 99%

Emerging non‑invasive detection methodologies for lung cancer (Review)

Shu

Yang

et al. 2020

Oncol Lett

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The potential for non-invasive lung cancer (LC) diagnosis based on molecular, cellular and volatile biomarkers has been attracting increasing attention, with the development of advanced techniques and methodologies. It is standard practice to tailor the treatments of LC for certain specific genetic alterations, including the epidermal growth factor receptor, anaplastic lymphoma kinase and BRAF genes. Despite these advances, little is known about the internal mechanisms of different types of biomarkers and the involvement of their related biochemical pathways during the development of LC. The development of faster and more effective techniques is essential for the identification of different biomarkers. The present review summarizes some of the latest methods used for detecting molecular, cellular and volatile biomarkers in LC and their potential use in clinical diagnosis and targeted therapy. Contents 1. Introduction 2. Emerging non-invasive detection technologies for lung cancer 3. Challenges and future directions

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“…Underlying cases for such serious maladies can be summarized as the lack of available analysis methods and subsequent treatment strategies due to the limited access of centralized and equipped health-care facilities [65]. Many researchers, such as physicists, chemists, biologists, and medical doctors, have used nanosensors as applications in several fields, including doping analysis [66], diagnosis [67], food safety [68], and laboratory medicine [69]. Among them, clinical applications have been researched as an impressive field of application.…”

Section: Significance Of Virus Detectionmentioning

confidence: 99%