Analysis of wall shear stress in stented coronary artery using 3D computational fluid dynamics modeling

Dehlaghi, Vahab; Shadpoor, Mohammad Tafazoli; Najarian, Siamak

doi:10.1016/j.jmatprotec.2007.06.010

Cited by 37 publications

(15 citation statements)

References 24 publications

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“…This highlights an important limitation of the idealised NDF approach, which requires that the configuration of these tapered sections is specified arbitrarily. It is also notable that these features (and the subsequent over-dilation of the stent) are often neglected in the literature [6,8,11,[13][14][15][17][18][19][20][21][24][25][26][27][28]. In the few studies that have included idealised tapered sections with NDF models of stented coronary arteries, similar regions of low WSS were predicted in the proximal region of the artery to those observed with the NDF models in this study [7,9,10,12].…”

Section: Discussionsupporting

confidence: 60%

Computational fluid dynamics analysis of balloon-expandable coronary stents: Influence of stent and vessel deformation

Martín¹,

Murphy²,

Boyle³

2014

Medical Engineering & Physics

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In many computational fluid dynamics (CFD) studies of stented vessel haemodynamics, the geometry of the stented vessel is described using non-deformed (NDF) geometrical models. These NDF models neglect complex physical features, such as stent and vessel deformation, which may have a major impact on the haemodynamic environment in stented coronary arteries. In this study, CFD analyses were carried out to simulate pulsatile flow conditions in both NDF and realistically-deformed (RDF) models of three stented coronary arteries. While the NDF models were completely idealised, the RDF models were obtained from nonlinear structural analyses and accounted for both stent and vessel deformation. Following the completion of the CFD analyses, major differences were observed in the time-averaged wall shear stress (TAWSS), time-averaged wall shear stress gradient (TAWSSG) and oscillatory shear index (OSI) distributions predicted on the luminal surface of the artery for the NDF and RDF models. Specifically, the inclusion of stent and vessel deformation in the CFD analyses resulted in a 32%, 30% and 31% increase in the area-weighted mean TAWSS, a 3%, 7% and 16% increase in the area-weighted mean TAWSSG and a 21%, 13% and 21% decrease in the area-weighted mean OSI for Stents A, B and C, respectively. These results suggest that stent and vessel deformation are likely to have a major impact on the haemodynamic environment in stented coronary arteries. In light of this observation, it is recommended that these features are considered in future CFD studies of stented vessel haemodynamics.

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Section: Discussionsupporting

confidence: 60%

Computational fluid dynamics analysis of balloon-expandable coronary stents: Influence of stent and vessel deformation

Martín¹,

Murphy²,

Boyle³

2014

Medical Engineering & Physics

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“…The identification of relationships between geometric variables and hemodynamic patterns can be used to infer which mechanical factors are more likely to be involved in the localization of disease (Dehlaghi et al, 2007;2008a;2008b;Wellnhofer et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Wall Shear Stress Distribution in Patient Specific Coronary Artery Bifurcation

Dehlaghi¹

2010

American Journal of Applied Sciences

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Problem statement: Atherogenesis is affected by hemodynamic parameters, such as wall shear stress and wall shear stress spatial gradient. These parameters are largely dependent on the geometry of arterial tree. Arterial bifurcations contain significant flow disturbances. Approach: The effects of branch angle and vessel diameter ratio at the bifurcations on the wall shear stress distribution in the coronary arterial tree based on CT images were studied. CT images were digitally processed to extract geometrical contours representing the coronary vessel walls. The lumen of the coronary arteries of the patients was segmented using the open source software package (VMTK). The resulting lumens of coronary arteries were fed into a commercial mesh generator (GAMBIT, Fluent Inc.) to generate a volume that was filled with tetrahedral elements. The FIDAP software (Fluent Corp.) was used to carry out the simulation by solving Navier-Stokes equations. The FIELDVIEW software (Version 10.0, Intelligent Light, Lyndhurst, NJ) was used for the visualization of flow patterns and the quantification of wall shear stress. Post processing was done with VMTK and MATLAB. A parabolic velocity profile was prescribed at the inlets and outlets, except for 1. Stress free outlet was assigned to the remaining outlet. Results: The results show that for angle lower than 90°, low shear stress regions are observed at the non-flow divider and the apex. For angle larger than 90°, low shear stress regions only at the nonflow divider. By increasing of diameter of side branch ratio, low shear stress regions in the side branch appear at the non-flow divider. Conclusion: It is concluded that not only angle and diameter are important, but also the overall 3D shape of the artery. More research is required to further quantify the effects angle and diameter on shear stress patterns in coronaries.

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“…By analyzing the hemodynamic parameters that includes wall shear stress, wall shear stress gradient, and pressure gradient, the simulation showed that TG did not show a better outcome compared to the CD. Dehlagi, et al (69) further analyzed the wall shear stress in stented coronary artery using 3D CFD model. In this part of the study, CFD was employed to simulate the motion of fluid in an orbiting dish.…”

Section: Finite Element Methods (Fem)mentioning

confidence: 99%

Fluid dynamic analysis of flow in orbiting dishes and the effects of flow on shear stress and endothelial cellular responses.

Chakraborty¹

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Analysis of wall shear stress in stented coronary artery using 3D computational fluid dynamics modeling

Cited by 37 publications

References 24 publications

Computational fluid dynamics analysis of balloon-expandable coronary stents: Influence of stent and vessel deformation

Computational fluid dynamics analysis of balloon-expandable coronary stents: Influence of stent and vessel deformation

Wall Shear Stress Distribution in Patient Specific Coronary Artery Bifurcation

Fluid dynamic analysis of flow in orbiting dishes and the effects of flow on shear stress and endothelial cellular responses.

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