Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle

Browne, Richard W.; Bloom, Michael S.; Schisterman, Enrique F.; Hovey, Kathy; Trevisan, Maurizio; Wu, Chengqing; Liu, Aiyi; Wactawski‐Wende, Jean

doi:10.1080/13547500701775563

Cited by 47 publications

(41 citation statements)

References 71 publications

(54 reference statements)

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“…Covas et al [23] reported that II for SOD and glutathione peroxidase in human blood was 0.45 (low individuality), suggesting that it has little value as a diagnostic or screening tool. The components of variation for MDA in human plasma reported in the literature [18,24] are similar to our values. The RCV is an important clinical tool for the assessment of changes in patient animal being monitored in pathologicalsituations [24,25] .…”

Section: Discussionsupporting

confidence: 80%

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Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazin Biyolojik Varyasyonu

Kurutaş¹,

Gül²

2015

Kafkas Univ Vet Fak Derg

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This is the first report, we aimed to determine the biological variations, analytical quality specifications of oxidative stress biomarkers such as glucose-6-phosphate dehydrogenase (G6PD), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH), malondialdehyde (MDA), and also lactic dehydrogenase (LDH) in mice. In the our study, Mus musculus albino mice, forty-one adult (female 20, male 21), weighing between 23 and 40 g were enrolled for biological variation study during 30-day period. Samples were stored and then tested at the same time. Results were assessed in duplicate and coefficients of variation for each analyte which were isolated to distinguish variation such as within-, and between-individual variations. From these results, an index of individuality were determined for each analyte. The analytical, within-individual, between-individual variations were assessed in apparently healthy mice and were found to be; 1.19%, 22.51% and 7.38% for G6PD, 14.09%, 23.03% and 29.42% for CAT, 6.18%, 11.12% and 21.14% for SOD, 9.13%, 12.00% and 12.58% for GST, 4.12%, 23.40% and 11.20% for GSH, 2.11%, 16.45% and 11.27% for LDH, 4.75%, 9.03% and 31.55% for MDA, respectively. As a result, while population-based reference intervals for G6PD, GSH and LDH were appropriate, Subject-based reference intervals for SOD and MDA were more appropriate. CAT and GST had intermediate individuality so population-based reference intervals should be used with caution. Keywords: Biological variation, lactic dehydrogenase, mice, oxidative stress biomarkers Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazın Biyolojik Varyasyonu ÖzetBu çalışma, glukoz-6-fosfat dehidrogenaz (G6PD), katalaz (CAT), süperoksit dismutaz (SOD), glutatyon S-transferaz (GST), indirgenmiş glutatyon (GSH), malondialdehit (MDA) gibi oksidatif stres biyobelirteçlerinin ve laktik dehidrogenaz (LDH)'ın biyolojik varyasyonlarını, analitik kalite spesifikasyonlarını ve referans aralıklarını saptamak amacıyla yapılan ilk araştırmadır.

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Section: Discussionsupporting

confidence: 80%

“…Limited studies have been conducted to address these methodological issues [17,18] and there is still controversy over which oxidative stress biomarkers and LDH to use. It has been suggested that oxidative stress biomarkers and LDH should be utilized for research purposes until more sensitive and specific assays are developed [19,20] .…”

Section: Discussionmentioning

confidence: 99%

Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazin Biyolojik Varyasyonu

Kurutaş¹,

Gül²

2015

Kafkas Univ Vet Fak Derg

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“…The variability in responses may, e.g., derive from non-standardized time difference between astaxanthin intake and blood sampling, a fl uctuating background intake from the diet, variable bioavailability, large distribution volume, (induced) degradation and others. High intra-and inter-individual bioavailability of carotenoids has been previously reported [15][16][17] and the present data on astaxanthin appear as no exception to this rule.…”

Section: Discussionmentioning

confidence: 44%

Kinetics of plasma and erythrocyte-astaxanthin in healthy subjects following a single and maintenance oral dose

Nunez¹,

Schuitemaker²,

Dijck-Brouwer³

et al. 2014

J Young Pharm.

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Aim and Background:Astaxanthin is a unique carotenoid of predominantly marine origin providing the pink-red color to certain microalgae and accumul ating in various animals higher in the food chain. It is an antioxidant without pro-oxidant properties or known side-effects following oral intake. Materials and Methods: We investigated astaxanthin kinetics in plasma and erythrocytes (red blood cells [RBC]) of four healthy adults after a single oral 40 mg dose. Plasma-and RBC-astaxanthin were measured during 72 h. Subsequently, an 8 mg/day dose was given during 17 days. Plasma-and RBC-astaxanthin were measured each morning. Results: Plasma-astaxanthin reached a peak (from 79 to 315 nmol/L) after 8 h and then declined (half-life, 18 h). Within 72 h, plasma-astaxanthin had returned to baseline. RBC-astaxanthin reached a peak (from 63 to 137 nmol/L packed cells) at 12 h and subsequently disappeared (half-life, 28 h). During the daily dose, plasma-astaxanthin increased until day 10 (187 nmol/L) and then decreased to a steady concentration similar to that reached after 2 days. RBC-astaxanthin appeared to be highly variable (group median concentration, 86 nmol/L packed cells). Conclusion: We found high intra-and inter-individual variations, especially in RBC, possibly due to non-standardized time difference between astaxanthin intake and sampling, fl uctuating background intake from the diet, variable bioavailability, large distribution volume, degradation or others. Oral astaxanthin is rapidly absorbed and incorporated into RBC. The subsequent rapid decline suggests that, for a higher-than-baseline status, astaxanthin should be taken daily, at least in an early phase when total body equilibrium, if any, has not been reached yet.

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“…The mechanisms that relate ROS with female fertility are not completely understood. Investigation of the relationships between ROS and female fertility and reproductive outcomes may be masked by normal menstrual cycle variation [4] . In order to comprehensively evaluate the relation between ROS and infertility, physiological variations across the normal estrous cycle in healthy cows should be known.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

Aydılek¹,

Varışlı²,

Selek³

et al. 2014

Kafkas Univ Vet Fak Derg

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Reactive oxygen species have fundamental roles in reproductive functions. To comprehensively evaluate the relation between reactive oxygen species and infertility, physiological variations across the estrous cycle in healthy cows have to be known. For this purpose 25 healthy multiparous Holstein dairy cows having regular estrous cycles were used. The estrous cycles were synchronized by ovsynch protocol. Oxidant [lipid hydroperoxide (LOOH), total oxidant status (TOS), oxidative stress index (OSI)], antioxidant parameters [total antioxidant status (TAS), total free sulfhydryl groups (SH), ceruloplasmin (CP), paraoxonase-1 (PON1), arylesterase (ARE), uric acid (UA)], lipid profile and progesterone levels were assayed at estrus, metestrus, diestrus and proestrus stages of the estrous cycle in the plasma samples. The plasma levels of oxidant (LOOH, TOS and OSI) and antioxidant (TAS, SH and UA) parameters were significantly decreased during the luteal phase compared to the follicular phase (at proestrus and at estrus) of the estrous cycle. There was also a significant positive correlation between TAS and TOS. The activity of PON1 and ARE significantly increased only at diestrus. Levels of high density lipoprotein, low density lipoprotein and total cholesterol elevated during the follicular phase (estrus) and declined during the luteal phase. In conclusion, oxidant/antioxidant status and lipid profile were affected by cyclic changes. Moreover, antioxidant defense system showed adaptive response to increased oxidative activities by occurring parallel increases and it may indicate that there is a dynamic balance between oxidant and antioxidant status during the estrous cycle in healthy cows. Keywords: Cow, Estrous cycle, Lipid peroxide, Lipid profile, Total antioxidant status, Total oxidant status Sütçü İneklerde Östrus Siklusunun Oksidan ve Antioksidan Parametreler Üzerine Etkisi ÖzetReaktif oksijen türlerinin üreme fonksiyonları üzerinde önemli rolleri vardır. Sağlıklı süt sığırlarında reaktif oksijen türleri ve infertilite arasındaki ilişkiyi kapsamlı bir şekilde değerlendirmek için östrus siklusu boyunca reaktif oksijen türü seviyelerindeki değişimlerin bilinmesi gerekir. Bu çalışmada düzenli siklus gösteren 25 adet sağlıklı Holştayn ırkı sütçü inek kullanıldı. Östrus siklusları ovsynch protokolü ile senkronize edildi. Östrus siklusunun proöstrus, östrus, metaöstrus ve diöstrus dönemlerinde kan plazmasında oksidan parametreler [lipit hidroperoksit (LOOH), total oksidan seviye (TOS), oksidatif stres indeksi (OSI)], antioksidan parametreler [total antioksidan kapasite (TAS), total serbest sülfhidril gruplar (SH), seruloplazmin (CP), paraoksonaz-1 (PON1), arilesteraz (ARE), ürik asit (UA)], lipit profili ve progesteron seviyesi ölçüldü. Foliküler dönemle karşılaştırıldığında luteal dönemdeki plazma oksidan (LOOH, TOS, OSI) ve antioksidan (TAS, SH, UA) seviyelerinin önemli derecede düştüğü görüldü. Ayrıca TAS ve TOS değerleri arasında önemli bir pozitif korelasyon vardı. Paraoksonaz-1 ve ARE aktiviteleri sadece diöstrus ...

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Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle

Cited by 47 publications

References 71 publications

Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazin Biyolojik Varyasyonu

Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazin Biyolojik Varyasyonu

Kinetics of plasma and erythrocyte-astaxanthin in healthy subjects following a single and maintenance oral dose

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

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