Excavation-damaged zones (EDZs) induced in underground mining and civil engineering potentially threaten tunnel safety and stability, and increase construction and support costs. In this paper, an investigation of the excavation damaged zone (EDZ) around roadways in Fankou lead-zinc mine in Guangzhou, China is performed by applying a seismic velocity method accompanied by SET-PLT-01 nonmetallic ultrasonic detector. Meanwhile, the in situ stress in the mining area was measured based on the stress relief method with the Swedish high-precision LUT system. The results indicate that the stress field is dominated by the maximum horizontal tectonic stress, and the extents of the EDZ on the roof-floor region are greater than that on the sidewall. In addition, both of the in situ stresses and EDZs show an increasing trend with an increase of depth. Analytical solutions of EDZ around circular openings in the brittle rock mass subjected to non-hydrostatic stress fields are presented in terms of the Mohr–Coulomb and generalized Hoek–Brown criteria, and validated by several cases mentioned above. The extents of EDZ solved by closed-form solutions were found to be in a great agreement with those obtained in the field. Finally, a series of parametric studies are conducted to investigate the effects of cohesion (c), friction angle (φ), geological strength index (GSI), mi, uniaxial compressive strength (σc), and disturbance factor (D) on EDZ. It is shown that the effects of c, φ, GSI, and σc are significant; however, more attention should be paid to consider the dynamic disturbances induced by mechanical drilling, blasting, and seismic waves in tunnel excavations or operations.