The radiation therapy is applied on around 50% of the cancer patients. As we know, before implementing a radiation treatment planning system in the clinic, the dose-calculation measurement must be validated using rigorous, clinically relevant criteria [1]. Percent Depth Doses (PDD), Dose Profile (DP), Open Collimator Factor (OCF) etc., are measured for all numbers of square fields for Treatment Planning System XiO, version 4.7, for 6 and 15 MV photons energies and for 15˚, 30˚, 45˚, 60˚ wedge, which were employed to obtain the profiles in any depth. The measurements were conducted also for different energies of electron beam and TPS calculation algorithms.