Analytical model for the magnetophoretic capture of magnetic microspheres in microfluidic devices

Nandy, Krishanu; Chaudhuri, Sayani; Ganguly, Ranjan; Puri, Ishwar K.

doi:10.1016/j.jmmm.2007.11.024

Cited by 94 publications

(59 citation statements)

References 23 publications

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“…Thus, for an operating zone of a module consisting of two opposing (mutually distanced at b=35mm) magnetic elements Nd-Fe-B, these parameters up to a comparatively narrow zone in the vicinity of module symmetry plane (which does not exceed a quarter of the module operating zone) [3] are:…”

Section: Resultsmentioning

confidence: 99%

“…With the values of induction and/or intensity at the surface of the magnetic element (x=0) amounting to В 0 =0,4T and Н 0 =В 0 /µ 0 =3,18·10 5 A/m, whereas the value of a multiplier in the exponent is k x =120 m -1 [3]. Therefore, the force factor entering in the expression…”

Section: Resultsmentioning

confidence: 99%

“…Firstly, this is by no means always taken into consideration (even though a number of papers pinpoint it [3][4][5][6][7][8]) that magnetic susceptibility χ of a certain body (a ferro-particle) greatly depends on its shape; besides, the connection of the body matter with its χ в susceptibility is [3,5,6,8]: 1/χ -1/χ в =N, where N is the body demagnetizing coefficient. E.g.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Specification of Force Influencing a Particle in a Magnetic Field

Sandulyak¹,

Sandulyak²,

Polismakova³

et al. 2017

dtetr

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Abstract. We elaborate a special case of solving the problem of the calculating expression and obtaining the corresponding data for the ferro-particles magnetic capture force: in the paraxial zone between two opposing and likewise distanced magnetic elements. To the effect, we try to bring out the full potential of the traditionally used classical expression for a magnetic force (which is fair if applicable to the point weakly susceptible ferro-particle) with its possible adjustment for studying a real ferro-object (a ball).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Specification of Force Influencing a Particle in a Magnetic Field

Sandulyak¹,

Sandulyak²,

Polismakova³

et al. 2017

dtetr

View full text Add to dashboard Cite

show abstract

“…7,8 With increasing advancements in microfluidics technology, it has become possible to capture these magnetic bead-particle complexes instead of guiding them to a separate output channel. 9 For particle capturing, the magnetic force can be less precise because the goal of the magnetic force is to simply overpower the combination of the other forces. Although many different forces affect the movement of beads or bead-particle complexes including magnetic, drag, particle/fluid interactions, inertia, buoyancy, gravity, thermal kinetics, and inter-particle effects, only the magnetic, drag, and gravitational forces are dominant.…”

Section: Introductionmentioning

confidence: 99%

Magnetophoretic-based microfluidic device for DNA isolation

Hale

Darabi

2014

Biomicrofluidics

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This paper presents a continuous flow microfluidic device for the separation of DNA from blood using magnetophoresis for biological applications and analysis. This microfluidic bio-separation device has several benefits, including decreased sample handling, smaller sample and reagent volumes, faster isolation time, and decreased cost to perform DNA isolation. One of the key features of this device is the use of short-range magnetic field gradients, generated by a micro-patterned nickel array on the bottom surface of the separation channel. In addition, the device utilizes an array of oppositely oriented, external permanent magnets to produce strong long-range field gradients at the interfaces between magnets, further increasing the effectiveness of the device. A comprehensive simulation is performed using COMSOL Multiphysics to study the effect of various parameters on the magnetic flux within the separation channel. Additionally, a microfluidic device is designed, fabricated, and tested to isolate DNA from blood. The results show that the device has the capability of separating DNA from a blood sample with a purity of 1.8 or higher, a yield of up to 33 lg of polymerase chain reaction ready DNA per milliliter of blood, and a volumetric throughput of up to 50 ml/h. V C 2014 AIP Publishing LLC.

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“…5 We therefore conduct a fundamental investigation of the mechanics of magnetic separation on a microfluidic platform using threedimensional numerical simulations. 3, 13 Previous studies have assumed binding when the gap between a particle and the target is smaller than a critical distance. 5 A mobility-and diffusion-dominated binding kinetics model can also be employed where every collision is assumed to result in particletarget binding.…”

Section: Introductionmentioning

confidence: 99%

Numerical investigation of flow-through immunoassay in a microchannel

Sinha

Ganguly

Puri

2010

Journal of Applied Physics

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Immunomagnetic separation (IMS) is a method to isolate biomaterials from a host fluid in which specifically selected antibodies attached to magnetic particles bind with their corresponding antigens on the surface of the target biological entities. A magnet separates these entities from the fluid through magnetophoresis. The method has promising applications in microscale biosensors. We develop a comprehensive model to characterize the interaction between target species and magnetic particles in microfluidic channels. The mechanics of the separation of target nonmagnetic N particles by magnetic M particles are investigated using a particle dynamics simulation. We consider both interparticle magnetic interactions and the binding of the functionalizing strands of complementary particles. The temporal growth of a particle aggregate and the relative concentrations of M and N particles are investigated under different operating conditions. A particle aggregate first grows and then exhibits periodic washaway about a quasisteady mean size. The washaway frequency and amplitude depend on the initial fractional concentration of N particles while the aggregate size scales linearly with the dipole strength and inversely with the fluid flow rate.

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Analytical model for the magnetophoretic capture of magnetic microspheres in microfluidic devices

Cited by 94 publications

References 23 publications

Specification of Force Influencing a Particle in a Magnetic Field

Specification of Force Influencing a Particle in a Magnetic Field

Magnetophoretic-based microfluidic device for DNA isolation

Numerical investigation of flow-through immunoassay in a microchannel

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