Analyzing aphasia data in a multidimensional symptom space

Bates, Elizabeth; Saygın, Ayşe Pınar; Moineau, Suzanne; Marangolo, Paola; Pizzamiglio, Luigi

doi:10.1016/j.bandl.2004.06.108

Cited by 17 publications

(7 citation statements)

References 15 publications

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“…In reality, most individual cases of aphasia are the consequence of varying degrees of damage to multiple independent but interacting language subsystems with distinct but overlapping neural substrates. Accordingly, each case of aphasia should be characterized not as one of a number of discrete types, but rather as a point in a multidimensional symptom space [ 7 – 11 ]. The specific dimensions defining this space should, as far as possible, reflect functions that have been empirically demonstrated to be neurally and functionally distinct.…”

Section: Introductionmentioning

confidence: 99%

A quick aphasia battery for efficient, reliable, and multidimensional assessment of language function

et al. 2018

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This paper describes a quick aphasia battery (QAB) that aims to provide a reliable and multidimensional assessment of language function in about a quarter of an hour, bridging the gap between comprehensive batteries that are time-consuming to administer, and rapid screening instruments that provide limited detail regarding individual profiles of deficits. The QAB is made up of eight subtests, each comprising sets of items that probe different language domains, vary in difficulty, and are scored with a graded system to maximize the informativeness of each item. From the eight subtests, eight summary measures are derived, which constitute a multidimensional profile of language function, quantifying strengths and weaknesses across core language domains. The QAB was administered to 28 individuals with acute stroke and aphasia, 25 individuals with acute stroke but no aphasia, 16 individuals with chronic post-stroke aphasia, and 14 healthy controls. The patients with chronic post-stroke aphasia were tested 3 times each and scored independently by 2 raters to establish test-retest and inter-rater reliability. The Western Aphasia Battery (WAB) was also administered to these patients to assess concurrent validity. We found that all QAB summary measures were sensitive to aphasic deficits in the two groups with aphasia. All measures showed good or excellent test-retest reliability (overall summary measure: intraclass correlation coefficient (ICC) = 0.98), and excellent inter-rater reliability (overall summary measure: ICC = 0.99). Sensitivity and specificity for diagnosis of aphasia (relative to clinical impression) were 0.91 and 0.95 respectively. All QAB measures were highly correlated with corresponding WAB measures where available. Individual patients showed distinct profiles of spared and impaired function across different language domains. In sum, the QAB efficiently and reliably characterized individual profiles of language deficits.

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Section: Introductionmentioning

confidence: 99%

A quick aphasia battery for efficient, reliable, and multidimensional assessment of language function

et al. 2018

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“…Traditional lesion-mapping methods risk losing important information: patient groups typically comprise a broad range of lesioned areas and behavioral deficits, but are grouped either within a pre-specified lesion region of interest, or within narrowly defined behavioral categories for evaluation purposes. In addition, clinical measures can be very broad, and measure a conglomerate of neuroanatomically distinct abilities (Bates, Saygin, Moineau, Marangolo, & Pizzamiglio, 2005). The VLSM technique (Bates et al, 2003) is an important advancement because it preserves continuous lesion and behavioral information; no categorization based on lesion site, clinical diagnosis, or behavioral performance is necessary.…”

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confidence: 99%

Lesion correlates of conversational speech production deficits

et al. 2007

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We assess brain areas involved in speech production using a recently developed lesion-symptom mapping method (voxel-based lesion-symptom mapping, VLSM) with 50 aphasic patients with left-hemisphere lesions. Conversational speech was collected through a standardized biographical interview, and used to determine mean length of utterance in morphemes (MLU), type token ratio (TTR) and overall tokens spoken for each patient. These metrics are used as indicators of grammatical complexity, semantic variation, and amount of speech, respectively. VLSM analysis revealed that damage to the anterior insula was predictive of low scores on MLU and tokens, consistent with prior findings of the role of this region in speech production [Dronkers, N. F. (1996). A new brain region for coordinating speech articulation. Nature, 384(6605), 159-161]. Additionally, the inferior frontal gyrus, sensorimotor and anterior temporal areas were also associated with lower scores on both of these measures. Overall, token and MLU maps were highly similar, suggesting an overlap between grammatical language networks and overall fluency. TTR maps also shared some portions of this network, but damage to posterior temporal regions also reduced scores on this measure. These results represent the first voxel-based lesion analysis of speech production performance in aphasic patients.

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“…Moreover, the reciprocal transformation allowed us to explicitly model potential ceiling effects in the data, revealing more subtle effects later in development. In general, continuous regressors should reveal more subtle effects than group analyses (Bates, Saygin, Moineau, Marangolo & Pizzamiglio, 2005; Zangl, Klarman, Thal, Fernald & Bates, 2005). We ran three types of linear regressions on the transformed data: (1) normal ordinary least squares linear regression; (2) robust regression (resilient to outliers with high leverage values); and (3) linear regression with robust standard errors (i.e.…”

Section: Resultsmentioning

confidence: 99%

The development of sentence interpretation: effects of perceptual, attentional and semantic interference

Leech

Aydelott

Symons

et al. 2007

Developmental Science

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How does the development and consolidation of perceptual, attentional, and higher cognitive abilities interact with language acquisition and processing? We explored children's (ages 5-17) and adults' (ages 18-51) comprehension of morphosyntactically varied sentences under several competing speech conditions that varied in the degree of attentional demands, auditory masking, and semantic interference. We also evaluated the relationship between subjects' syntactic comprehension and their word reading efficiency and general 'speed of processing'. We found that the interactions between perceptual and attentional processes and complex sentence interpretation changed considerably over the course of development. Perceptual masking of the speech signal had an early and lasting impact on comprehension, particularly for more complex sentence structures. In contrast, increased attentional demand in the absence of energetic auditory masking primarily affected younger children's comprehension of difficult sentence types. Finally, the predictability of syntactic comprehension abilities by external measures of development and expertise is contingent upon the perceptual, attentional, and semantic milieu in which language processing takes place.

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Analyzing aphasia data in a multidimensional symptom space

Cited by 17 publications

References 15 publications

A quick aphasia battery for efficient, reliable, and multidimensional assessment of language function

A quick aphasia battery for efficient, reliable, and multidimensional assessment of language function

Lesion correlates of conversational speech production deficits

The development of sentence interpretation: effects of perceptual, attentional and semantic interference

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