Malaria is one of the most infectious diseases in the world, particularly in developing continents such as Africa and Asia. Due to the high number of cases and lack of sufficient diagnostic facilities and experienced medical personnel, there is a need for advanced diagnostic procedures to complement existing methods. For this reason, this study proposes the use of machine-learning models to detect the malaria parasite in blood-smear images. Six different features—VGG16, VGG19, ResNet50, ResNet101, DenseNet121, and DenseNet201 models—were extracted. Then Decision Tree, Support Vector Machine, Naïve Bayes, and K-Nearest Neighbour classifiers were trained using these six features. Extensive performance analysis is presented in terms of precision, recall, f-1score, accuracy, and computational time. The results showed that automating the process can effectively detect the malaria parasite in blood samples with an accuracy of over 94% with less complexity than the previous approaches found in the literature.