Anaphylactic Reaction Induced by Diclofenac: A Case Report

Sanuki, Takuro; Sugioka, Shingo; Kotani, Junichiro

doi:10.1016/s1348-8643(10)80011-4

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Similar conclusions have been also observed in other studies [ 7 , 8 ]. There have been a few reported single cases of anaphylactic shock after the administration of diclofenac: after oral ingestion [ 9 , 10 , 11 , 12 ], one after intravenous injection [ 13 ] and four after intramuscular injection [ 14 , 15 , 16 ], two cases after rectal administration [ 17 , 18 ], and one after received the diclofenac patch [ 18 ]. Picaud et al [ 19 ] described nine cases of hypersensitivity to diclofenac registered by the Allergy Vigilance Network in France between 2002 and 2012.…”

Section: Introductionmentioning

confidence: 99%

Diclofenac Concentrations in Post-Mortem Specimens—Distribution, Case Reports, and Validated Method (UHPLC-QqQ-MS/MS) for Its Determination

Szpot

Wachełko²,

Zawadzki

2022

Toxics

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The aim of the research was to establish a sensitive method for the quantification of diclofenac in postmortem samples. The developed method was applied in six cases: three fetuses in which the use of abortion pills by their mothers was suspected, one case of duodenal ulcer perforation, one case of traffic accident with fatal outcome, and one acute renal failure in which the distribution of diclofenac was examined. The analyses were performed using liquid–liquid extraction of postmortem samples and the quantification of diclofenac via ultra-high performance liquid chromatography, coupled with triple quadrupole tandem mass spectrometry. Gradient elution using a C18 column was applied. Electrospray ionization measurement in positive multiple reaction monitoring mode was used. Diclofenac-d4 was used as an internal standard. The validation parameters were as follows: lower limit of quantification: 0.5 ng/mL, linearity of calibration curve: 0.5–500 ng/mL, intra- and interday accuracies and precisions: not greater than 15%; recovery values: 72.0–102.2%, and matrix effect: 2.2–28.0%. The developed method enabled the determination of diclofenac in human postmortem biological fluids (blood, urine, vitreous humor, bile, and stomach content), tissues (placenta, kidney, liver, and heart), and in exhumated fetus bones, with high recovery, sensitivity, precision, and accuracy.

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Section: Introductionmentioning

confidence: 99%

Diclofenac Concentrations in Post-Mortem Specimens—Distribution, Case Reports, and Validated Method (UHPLC-QqQ-MS/MS) for Its Determination

Szpot

Wachełko²,

Zawadzki

2022

Toxics

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A Case Report Study of Diclofenac–induced Severe Fixed Drug Eruption

Ganjikunta¹,

Vudayana²,

Avula³

2016

jebmh

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Diclofenac is a widely used non-steroidal anti-inflammatory drug (NSAID). The most common reported adverse drug reactions (ADRs) of diclofenac are nausea, vomiting, epigastric pain, headache and dizziness. Fixed drug eruption (FDE) is also one ADR due to diclofenac, which is even though not uncommon, in this case the severity is very high. That has made us to focus on this case. A 52-year-old male patient attended the skin OPD (outpatient department) with multiple erythematous patches over face, neck, upper limbs and lower limbs which were started after taking diclofenac for sprain injury. After complete history, the patient said he had similar complaints in the past for same drug. Patient started showing improvement after stopping diclofenac. Completely recovered after 10 days.

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Anaphylactic Reaction Induced by Diclofenac: A Case Report

Cited by 2 publications

References 12 publications

Diclofenac Concentrations in Post-Mortem Specimens—Distribution, Case Reports, and Validated Method (UHPLC-QqQ-MS/MS) for Its Determination

Diclofenac Concentrations in Post-Mortem Specimens—Distribution, Case Reports, and Validated Method (UHPLC-QqQ-MS/MS) for Its Determination

A Case Report Study of Diclofenac–induced Severe Fixed Drug Eruption

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