Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway

Guo, Jun; Hu, Zhibo; Yan, Feng-Juan; Lei, Sisi; Li, Ting; Li, Xiaoyü; Xu, Chaofei; Sun, Bei; Pan, Congqing; Chen, Liming

doi:10.1016/j.freeradbiomed.2020.08.015

Cited by 69 publications

(48 citation statements)

References 30 publications

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“…et al, 2017 ). Another study conducted in db/db mice with full-thickness cutaneous wound found that Angelicae dahuricae radix 70% ethanolic extract treatment (1.8 g/kg once daily by oral gavage) resulted in the reduced wound area, increased neovascularization, elevated PDGF-β expression, and increased capillary formation ( Guo et al, 2020 ). Its potential mechanisms were studied using human umbilical vein endothelial cells (HUVECs) and results showed that Angelicae dahuricae radix extract stimulated the angiogenesis via the activation of ERK1/2, PI3K/Akt, and eNOS/NO signaling pathways ( Zhang XN.…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

“…Its potential mechanisms were studied using human umbilical vein endothelial cells (HUVECs) and results showed that Angelicae dahuricae radix extract stimulated the angiogenesis via the activation of ERK1/2, PI3K/Akt, and eNOS/NO signaling pathways ( Zhang XN. et al, 2017 ) as well as the HIF-1α/PDGF-β signaling pathway ( Guo et al, 2020 ).…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

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Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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Chronic and unhealed wound is a serious public problem, which brings severe economic burdens and psychological pressure to patients. Various botanical drugs in traditional Chinese medicine have been used for the treatment of wounds since ancient time. Nowadays, multiple wound healing therapeutics derived from botanical drugs are commercially available worldwide. An increasing number of investigations have been conducted to elucidate the wound healing activities and the potential mechanisms of botanical drugs in recent years. The aim of this review is to summarize the botanical drugs in traditional Chinese medicine with wound healing properties and the underlying mechanisms of them, which can contribute to the research of wound healing and drug development. Taken together, five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.

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Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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“…The proliferation stage is accompanied by the formation of granulation tissue and the deposition of collagen fibers [ 27 ]. Fibroblasts are ubiquitously present in the connective tissue of every organ system where they deposit and remodel the extracellular matrix (ECM) [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

Liu

Geng

et al. 2022

Molecules

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Nowadays, natural polysaccharides-based hydrogels have achieved promising results as dressings to promote skin healing. In the present study, we prepared a novel hydrogel nanocomposite with poly(vinyl alcohol) (PVA) and sulfated heterosaccharide (UF), named UPH. The SEM results showed that the UPH had dense porous structures with a high porosity and a specific surface area. The UPH had a good swelling property, which can effectively adsorb exudate and keep the wound moist. The in vitro experiments results showed that the UPH was non-cytotoxic and could regulate the inflammatory response and promote the migration of fibroblasts significantly. The phenotypic, histochemistry, and Western blot analyses showed UPH treatment accelerated the wound healing and recovery of skin tissue at wound sites in a C57BL/6 mouse model. Furthermore, the UPH could promote the inflammation process to onset earlier and last shorter than that in a normal process. Given its migration-promoting ability and physicochemical properties, the UPH may provide an effective application for the treatment and management of skin wounds.

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“…Previous evidence has shown that HIF-1α could promote tissue repair by upregulating the expression of target genes to increase oxygen delivery to the injured tissue in hypoxia adaptation [18,29]. Recent study has shown that HIF-1α-modi ed ADSCs could recruit an existing endogenous endothelial cell population to induce angiogenesis in a 3D cell construct in vitro [30].…”

Section: Discussionmentioning

confidence: 99%

HIF-1α overexpression in adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia-induced dysfunction and inflammation in HUVECs

Chen¹,

Sun²,

Lei³

et al. 2021

Preprint

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Background Increasing evidence suggests that ADSCs execute their paracrine function via the secretion of exosomes, especially under hypoxic conditions. However, the mechanisms by which ADSCs-derived exosomes (ADSC-exos) enhance angiogenesis under hypoxia remain unclear. Methods Exosomes were isolated from HIF-1α-modified ADSCs culture supernatants. To investigate the effects HIF-1α-ADSC-exos on HUVECs, cell growth, apoptosis, and tube formation assay were performed with or without HIF-1α-ADSC-exos. Moreover, to determine the function of HIF-1α-ADSC-exos, the therapeutic effects of ADSC-exos and HIF-1α-ADSC-exos were examined in PAH rats. Results Exosomes released by HIF-1α-modified ADSCs rescued the impaired angiogenic ability, migratory function, and inflammatory factors of hypoxia-injured HUVECs, with increased SDF-1α, Rac1, Rac2, VEGF and IL-10 expression. Furthermore, exos-HIF-1α activated SIRT3 to enhance angiogenesis in HUVECs and induced IL-10 expression to inhibit inflammatory response. Block SIRT3 or SDF-1α abolished the angiogenic effect in HUVECs. Conclusion Our findings indicated that the SIRT3 contributed a crucial role in HIF-1α-ADSC-exos in tissue repair under hypoxia.

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Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway

Cited by 69 publications

References 30 publications

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

HIF-1α overexpression in adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia-induced dysfunction and inflammation in HUVECs

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