Angiocentric glioma from a perspective of A-B-C classification of epilepsy associated tumors

Adamek, Dariusz; Siwek, Grzegorz Przemysław; Chrobak, Adrian Andrzej; Herman‐Sucharska, Izabela; Kwiatkowski, Stanisław; Morga, Rafał; Radwańska, Edyta; Urbanowicz, Barbara

doi:10.5114/fn.2016.58914

Cited by 9 publications

(15 citation statements)

References 18 publications

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“…According to the WHO Classi cation, 2016 edition 40 , glioma are classi ed as diffuse gliomas (astrocytoma, oligodendroglioma, glioblastoma), as well as circumscribed and low-grade gliomas (angiocentric glioma, pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, pilomyxoid astrocytoma, ependymoma, myxopapillary ependymoma, and subependymoma). Some study results showed that most patients with angiocentric glioma were children and young people, with no signi cant gender difference, and epilepsy was the main clinical manifestation 41 . Diffuse astrocytoma and oligodendroglial tumors were common in the cerebral hemisphere of young patients (frontal and temporal lobes were common), and epilepsy was one of the most common clinical symptoms 42 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that the risk of seizures decreases with age and men were at higher risk than women. Tumor location (frontal, temporal, cap, pillow, island) and the WHO classi cation ( ~ grade) were also associated with BTRE [20][21] . The incidence of BTREs in frontal lobe, temporal lobe, insular lobe and parietal lobe were higher than that in deep tumor tissues 22 .…”

Section: Introductionmentioning

confidence: 96%

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Correlation of Brain Tumor-related Epilepsy With Clinicopathological Factors in Gliomas

Jiang

Zhang

et al. 2021

Preprint

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Objectives: Glioma patients with brain tumor-related epilepsy (BTRE) have a complex profile due to the simultaneous presence of two pathologies: glioma and epilepsy. However, the underlying pathophysiology of BTRE remains poorly understood. The purpose of this study is to investigate the correlation between molecular neuropathology and glioma with BTRE.Methods: A retrospective cohort study of 186 glioma patients was evaluated at our hospital, with 64 presenting with BTRE. Chi-square test, spearman rank correlation and multivariate logistic analyses were used to identify clinicopathological factors associated with BTRE. Results: Of the 186 patients examined in this study, 64 (34.4 %) had BTRE. By analyzing the characteristics of these patients, the results showed that patient age (over 40 years; p=0.007), low WHO grade (grade I, II; p = 0.001), IDH-1 positive mutation (p=0.027), ATR-X low expression level (OR=0.44; 95% CI: 0.21, 0.92) and low Ki-67 proliferation index (OR=0.25; 95% CI: 0.10, 0.68) were associated with the occurrence of BTRE. BTRE did not differ by sex, tumor location, expression of olig-2 or CD34. The results of the matching study showed that low Ki-67 proliferation index and negative ATR-X expression level were independent factors for a higher incidence of preoperative seizures in glioma patients. Conclusion: The current study updates existing information on genetic markers in gliomas with BTRE and explores the correlation of a wide range of clinicopathological factors and glioma patients with BTRE. Our study suggests that three putative biomarkers for BTRE: positive IDH1 mutation, low Ki-67 proliferation index and negative ATR-X expression. These factors may provide insights for developing a more thorough understanding of the pathogenesis of epilepsy and effective treatment strategies aimed at seizure control.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Correlation of Brain Tumor-related Epilepsy With Clinicopathological Factors in Gliomas

Jiang

Zhang

et al. 2021

Preprint

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“…Закономерным результатом этих представлений стал выход новой классификации опухолей ЦНС ВОЗ от 2016 г. Впервые в основу классификации положено не только гистологическое строение новообразования, но и его наиболее значимая молекулярно-генетическая характеристика или хромосомная аберрация [77][78][79]. За последние годы в опухолях головного мозга было выявлено несколько молекулярных маркеров: мутации в гене изоцитратдегидрогеназы 1/2 (IDH1/2), коделеции 1p/19q, метилирование промотора MGMT, мутация К27М в гене H3F3A, мутация BRAF V600E и др., которые имеют существенное значение для прогноза и терапии заболевания [80][81][82][83]. В частности, F. Stockhammer et al обнаружили связь между эпиприступами, как первым симптомом опухоли, и наличием мутации IDH1/2 в диффузных глиомах низкой степени злокачественности [84].…”

Section: иммунологический статус и локальные иммунные реакцииunclassified

Modern conceptions about the pathogenesis of tumor-related epilepsy

Tolstykh

Викторовна²,

Гурчин

et al. 2019

Medical academic journal

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Tumor-related epilepsy is of interest among the symptomatic epilepsy, that develops in 75% of patients with gliomas low-grade (astrocytomas, oligodendrogliomas — Gr II) and more than 95% of patients with glioneuronal tumors (ganglioglioma — Gr I). Currently, the nature of epileptogenic activity in brain tumors is still controversial, and the search for epileptogenic foci that are part of the tumor zone presents certain difficulties. The authors described the structural changes and metabolism in the tumor and peritumoral zone, immunological status, and molecular genetic features of the tumor, which may explain the pathogenesis of tumor-related epilepsy. In turn, the clarification of the mechanisms of epileptogenesis is a prerequisite for the development of therapeutically effective anticonvulsants, and to improve the strategies of complex treatment of tumors associated with epilepsy.

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“…Differential diagnoses include astroblastoma, ependymoma, and papillary glioneuronal tumors. 21 Tumor cells do not harbor IDH or BRAF mutations, and the presence of either would suggest an alternative diagnosis. There is one report of malignant transformation to anaplastic ependymoma.…”

Section: Neuro-oncologymentioning

confidence: 99%

Uncommon low-grade brain tumors

et al. 2018

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An initial search of PubMed used broad search terms 'brain tumors', 'low-grade', 'radiotherapy, 'chemotherapy', 'surgery' and 'treatment' from January 1990 to March 2018. A subsequent focused search was undertaken using the names of individual histological subtypes of low-grade brain tumors as in the 2016 WHO classification. Only papers published in English were reviewed. The final reference list was generated on the basis of originality and relevance to the broad scope of this review.

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Angiocentric glioma from a perspective of A-B-C classification of epilepsy associated tumors

Abstract: A b s t r a c t Angiocentric glioma (AG) is a newly-classified, very rare, WHO grade I central nervous system (CNS) lesion

Cited by 9 publications

References 18 publications

Correlation of Brain Tumor-related Epilepsy With Clinicopathological Factors in Gliomas

Correlation of Brain Tumor-related Epilepsy With Clinicopathological Factors in Gliomas

Modern conceptions about the pathogenesis of tumor-related epilepsy

Uncommon low-grade brain tumors

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