Angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma of minor salivary glands

Abstract

Angiogenesis seems important in the modulation of mucoepidermoid carcinoma pathogenesis; however, none of the parameters analyzed could predict tumor behavior.

Semaphorins and neuropilins expression in salivary gland tumors

“…Considering previous studies by both our group and others reporting VEGF overexpression in malignant SGTs and its correlation with clinicopathological parameters, the expression of the proteins investigated in this study is in line with the rationale proposed for VEGF/class 3 semaphorins/neuropilins molecular interactions in a neoplastic environment, with a higher expression of neuropilins (especially Np‐2) and their co‐expression in malignant tumors than in benign lesions and normal tissues, and an inverted distribution for semaphorins, especially Sema3A whose expression is significantly decreased in malignancies, favoring, therefore, the pro‐angiogenic and oncogenic action of VEGF in malignant SGTs through its possible interaction with neuropilin co‐receptors.…”

“…These results illustrate the clinical importance of the vascular pattern of the tumors, but because vascular density and vascular area did not directly correlate with patients' prognosis, these results are also in contrast with previous reports that found CD34 vascular density as an independent determinant of tumor aggressiveness and prognostic biomarker for patients affected by SGTs . The use of the neoangiogenesis‐related marker CD105 could have better illustrated this process in the tumors analyzed , but to more appropriately compare our results with those previously described in the literature comparing semaphorins and neuropilins with neoplastic vascular pattern, we opted for using the pan‐endothelial marker CD34.…”

“…Although the formation of new blood vessels is widely known to represent an essential step in the progression of human cancer , the angiogenic properties of SGT have only superficially been investigated and the factors responsible for the development, or inhibition, of new blood vessel formation in SGT requires further exploration. Previous studies have demonstrated the upregulation of the pro‐angiogenic vascular endothelial growth factor (VEGF) in salivary gland malignancies, but its prognostic and therapeutic relevance is debatable and poorly understood .…”

Angiogenesis and Lymphangiogenesis in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma

“…In the analysis of lymphangiogenesis in mucoepidermoid carcinoma, intratumoral LVD was higher than peritumoral LVD, and the difference was statistically significant. Nevertheless, in a study by Gleber-Netto et al, (2012) on mucoepidermoid carcinoma of minor salivary glands, peritumoral LVD was greater than intratumoral LVD, which is not consistent with the results of the present study. In our study, peritumoral LVD was higher than intratumoral LVD in adenoid cystic carcinoma; however, the difference was not significant.…”

Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors

“…In MEC, Gleber-Neto et al found few cases (23 %) with intratumoral lymphatic microvessel analyzed by D2-40 and mean of 0.54 ± 1.15 lymphatic vessels per case [36]. In contrast, our results exhibited 64.2 % of cases with detectable LMD and mean of 12.7 ± 15.7 per case.…”