2015
DOI: 10.1097/ico.0000000000000609
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Angiographic and In Vivo Confocal Microscopic Characterization of Human Corneal Blood and Presumed Lymphatic Neovascularization

Abstract: CoNV can be characterized in vivo using a combination of IVCM and angiography. The vascular features vary according to the age of the CoNV and disease activity. Further improvements in angiographic image alignment, however, are needed.

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Cited by 27 publications
(16 citation statements)
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“…12,13 Although the efficacy of FND in the treatment of corneal hematic vessels is evident, its effect on corneal lymphatic or plasma vessels in CoNV as recently shown by our group remains to be investigated. 12,16,17 Optical coherence tomography (OCT) angiography may offer an additional complimentary approach, but at present, it is not able to distinguish between afferent and efferent vessels. [19][20][21] Although OCT angiography is likely to be a very useful adjunct, the current methods are limited in resolution to an axial and lateral resolution of approximately 5 to 8 mm and 20 to 20 mm 22 so that components of small vessels such as capillary loops may not be discernible.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…12,13 Although the efficacy of FND in the treatment of corneal hematic vessels is evident, its effect on corneal lymphatic or plasma vessels in CoNV as recently shown by our group remains to be investigated. 12,16,17 Optical coherence tomography (OCT) angiography may offer an additional complimentary approach, but at present, it is not able to distinguish between afferent and efferent vessels. [19][20][21] Although OCT angiography is likely to be a very useful adjunct, the current methods are limited in resolution to an axial and lateral resolution of approximately 5 to 8 mm and 20 to 20 mm 22 so that components of small vessels such as capillary loops may not be discernible.…”
Section: Discussionmentioning
confidence: 99%
“…15 The identified afferent vessels are colocalized on color photographs using visible landmarks such as a vessel branch to guide selective arteriolar FND. 9,16,17 Semiautomated programs using Matlab R14 (The MathWorks Inc, Natick, MA) are helpful in analyzing vessel parameters such as area of CoNV and vessel length, diameter, branch points, and tortuosity, which are useful information for monitoring outcome. 13,14 It is important to note that the afferent (arterial) vessels usually lie below and deeper in the corneal stroma to the associated venules, are often not visible on color images, and may not be easily discernible on slit-lamp biomicroscopy.…”
Section: Image Analysismentioning
confidence: 99%
“…These methods, however, are technically challenging and require improvements due to difficulties with image alignment. 39 En face optical coherence tomography angiography Ang and colleagues have adapted the use of the AngioVue OCTA system for corneal optical coherence tomography (OCT) angiography. 40,41 In their Review Corneal Disorders of the vessels.…”
Section: Assessment and Imaging Of Corneal Neovascularisation Clinicamentioning
confidence: 99%
“…Previous studies have characterized limbal/corneal lymphatics in mice and humans (12,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”
Section: Introductionmentioning
confidence: 99%