Angiolymphoid hyperplasia demonstrating extensive skin and mucosal lesions controlled with vinblastine therapy

A Case of Angiolymphoid Hyperplasia With Eosinophilia Treated With Intralesional Interferon Alfa-2a

“…9 Although ALHE is considered a benign disease, it can be resistant to multiple therapies, and can become disfiguring to the patient. Several treatment modalities have been described in the literature, including excision, 10 electrodessication and curettage, 11 radiotherapy, 2 carbon dioxide laser, 12 pulsed dye lasers, 13 intralesional and systemic corticosteroid therapy, 14 cryosurgery, 15 pentoxifylline, 16 cessation of estrogen therapy, 3 systemic vinblastine sulfate, 17 oral retinoids, 18 and indomethacin. 19 Interferon alfa is a naturally occurring cytokine that has antiviral, antibacterial, anticancer, anti-inflammatory, and immunomodulatory effects.…”

Hiperplasia angiolinfóide com eosinofilia: relato de dois casos

“…6 Outras modalidades terapêu-ticas têm sido propostas, entre elas: criocirurgia com nitrogê-nio líquido, laserterapia, 12 radioterapia local, 13 ácido retinói-co aromático, 14 vinblastina em paciente com extenso envolvimento cutâneo e mucoso, 15 acitretina 16 e corticoterapia local e/ou intralesional, especialmente em casos recidivantes. Remissão espontânea pode ocorrer.…”

Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin

“…Cryotherapy [20], lasers [21][22][23], electrodessication, or radiation therapy [15] have also been reported to be unsuccessful. Although EH is reported to respond to some drugs including pentoxifylline, systemic retinoids, interferon-alpha, and vinblastine [24][25][26][27], the role of pharmacological treatment is not established. Tranilast (N- [3,4-dimethoxycinnamonyl]anthranilic acid) was originally an anti-allergic drug used in Japan and Korea.…”