Angiolymphoid hyperplasia with eosinophilia on penis in HIV-positive patient: An unusual presentation

“…Epithelioid hemangioma, also known as angiolymphoid hyperplasia with eosinophilia, represents a rare vascular proliferation with a predilection for the ear, forehead and scalp . Occurrence on the penis is rare and all but two reported cases have been solitary or 2 closely grouped nodules treated with surgical excision . Histopathologically, it may be misdiagnosed as an epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule (CEAN), or Kaposi sarcoma …”

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confidence: 87%

“…Epithelioid hemangioma presents as variably painful, firm, indurated papules and nodules that may develop anywhere on the penis. They are most commonly solitary and rarely multifocal . Onset most frequently occurs in the mid‐forties, but involvement has occurred as young as 7 years and as old as 75.…”

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confidence: 99%

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Multifocal Epithelioid Hemangioma of the Penis: A Diagnostic and Therapeutic Challenge

Mutgi

Swick

2015

J Cutan Pathol

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“…Penile lesions are rare, and most of the cases were reported as solitary lesions; multiplicity is a rare entity. [3][4][5][6][7][8][9][10][11][12][13]16,17 Histopathologically, it presents with vascular proliferation with mixed inflammatory infiltrate. It may be misdiagnosed as Kaposi sarcoma (KS), epithelioid hemangioendothelioma, cutaneous epithelioid angiomatous nodule (CEAN), or epithelioid angiosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Diagnostically Challenging Multifocal Penile Epithelioid Hemangioma Successfully Treated With Doxorubicin Hydrochloride

Fawzi,

El Anany,

Abdelraouf

et al. 2024

The American Journal of Dermatopathology

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Epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is an unusual vascular proliferation that tends to manifest in the head and neck region. Its occurrence on the penis is rare, with only scarce reported cases in the literature. The histopathological examination of this condition poses a challenge because it shares similarities with other entities, such as epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule, or Kaposi sarcoma (KS). The infrequency of EH in penile locations underscores the need for accurate diagnostic differentiation and tailored treatment strategies for this atypical presentation. This case report highlights a rare instance of multifocal penile EH. The patient's lesions exhibited distinctive histopathologic features, with extensive eosinophilic infiltration, presence of necrosis, and infiltration to subcutaneous fat. The patient was treated with doxorubicin, a chemotherapy drug, with a very good response. This successful therapeutic outcome underscores the potential efficacy of doxorubicin in the management of multifocal penile EH. The comprehensive analysis of this case contributes to our understanding of the clinical presentation, histopathologic features, and treatment modalities for this rare penile tumor, providing valuable insights for future clinical considerations.

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Angiolymphoid hyperplasia with eosinophilia on penis in HIV-positive patient: An unusual presentation

Cited by 5 publications

References 3 publications

Spontaneous regression of angiolymphoid hyperplasia with eosinophilia of lacrimal gland in an HIV-positive patient

Spontaneous regression of angiolymphoid hyperplasia with eosinophilia of lacrimal gland in an HIV-positive patient

Multifocal Epithelioid Hemangioma of the Penis: A Diagnostic and Therapeutic Challenge

Diagnostically Challenging Multifocal Penile Epithelioid Hemangioma Successfully Treated With Doxorubicin Hydrochloride

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