Angiomatoid fibrous histiocytoma in a 25-year-old male

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation

“…Based on the review of the cases reported in the literature [5][6][7][8][9][10][11][12][13][14][15] and a preliminary review of some of the cases included in this series, the following imaging characteristics of the masses were assessed: …”

“…Patients usually present with a painless, slow-growing, deep subcutaneous mass in the extremities; however, the mass may also arise in other regions of the body including head and neck, trunk, retroperitoneum and lung [3,4]. Although the clinical and histological findings of angiomatoid fibrous histiocytoma have been well-described in large series of patients, especially in adults, there is little information in the literature regarding its imaging findings, particularly in children [5][6][7][8][9][10][11][12][13][14][15].…”

Subcutaneous Angiomatoid Fibrous Histiocytoma Mimicking Metastatic Melanoma

“…In our case the initial diagnosis was metastatic melanoma in a lymph node, due to the dense capsule and the surrounding plasmalymphocytic infiltrate and focal aspecific staining of lesional cells for melanocytic markers [12, 26, 27]. Careful revision eventually revealed the absence of structures normally found in lymph nodes, such as a subcapsular sinus and triggered further research on the origin of the present tumor.…”

Recurrent Painful Perianal Subcutaneous Angiomatoid Fibrous Histiocytoma

“…Despite previous studies, it is still hard to differentiate AFH from malignant fibrous histiocytoma, sarcoma, or other tumors with imaging alone. 12 On CT images, these confusable heterogeneous soft-tissue mass in the extremities are usually isodense to muscle with high attenuating areas corresponding with hemorrhaging. MRI is superior to CT in depicting fluid–fluid levels within the cystic component of the mass, indicative of intralesional hemorrhage.…”