Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators

Abstract

First, patients' serum Ang-2 levels are increased during severe sepsis and associated with disease severity. The strong relationship of serum Ang-2 with serum tumor necrosis factor-alpha suggests that the latter may participate in the regulation of Ang-2 production in sepsis. Second, inflammatory mediators reduce Ang-2 release from human lung microvascular endothelial cells, implying that this vascular bed may not be the source of increased Ang-2 in human sepsis.

Ang-2, Tie-2, and Ang-2/Tie-2 ratio serum levels as diagnostic and prognostic biomarkers of sepsis in critically ill patients

“…In agreement with the present results, several studies exhibited a positive correlation between Ang-2 serum levels and the severity of the sepsis [18,21]. A statistically significant association between serum levels of Ang-2 and mortality was not demonstrated in the present study, despite this being reported in other studies [29].…”

“…Increased plasma Ang-2 levels are reported in critically ill patients with sepsis and are associated with increased hospital mortality [17,18,19,20,21], as well as being correlated with the severity of illness [16,22].…”

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

“…In critically ill patients, the release of Ang-2 directly reflects vascular barrier breakdown. Orfanos et al (2007) could demonstrate that Ang-2 serves as marker to discriminate between sepsis and severe sepsis (p < 0.05). The authors investigated serum Ang-2 levels and could also show that Ang-2 acts similar to tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, two very important sepsis markers (p < 0.001).…”

Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone

“…2 While the role of angiopoietin 2 (Ang2) in regulating angiogenesis and vascular integrity has been well recognized, 7,8 recent reports have implicated an important role in inflammation. [9][10][11][12] Ang2 expression is increased dramatically at the sites of endothelial activation and is induced by various cytokines. 13 The release of Ang2 resulted in rapid destabilization of the endothelium and triggered an inflammatory response.…”