Angiotensin-(1–7): A Novel Peptide in the Ovary

Costa, Amilton Paulo Raposo; Fagundes-Moura, Christiane R.; Pereira, Virginia M.; Silva, Leonardo F.; Vieira, Maria Aparecida Ribeiro; Santos, Robson A.S.; Reis, Adelina Martha dos

doi:10.1210/en.2002-220787

Cited by 58 publications

(71 citation statements)

References 42 publications

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“…Ang-(1-7) was first described in rat ovaries and was shown to be regulated during the estrous cycle (Costa et al 2003). Recently, Ang-(1-7), MAS receptor, and ACE2 were identified in all the stages of follicular development in humans (Reis et al 2011).…”

Section: Ang-(1-7) and Follicle Development And Ovulationmentioning

confidence: 99%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

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Section: Ang-(1-7) and Follicle Development And Ovulationmentioning

confidence: 99%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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“…A regulação dos componentes do sistema Ang II demonstra a participação deles durante a ovulação; no entanto, a Ang II não é o único peptídeo ativo do SRA. Outros peptídeos gerados a partir da Ang I e Ang II, como a Ang-(1-7) (FELIX et al, 1991), também podem mediar as ações do SRA em diferentes processos fisiológicos (COSTA et al, 2003;SAMPAIO et al, 2007).…”

Section: Introductionunclassified

“…A expressão de RNAm para MAS foi verificada em vários tecidos, incluindo ovários de roedores e bovinos (COSTA et al, 2003;SANTOS et al, 2011) e testículos de ratos e homens (METZGER et al, 1995;REIS et al, 2010). No entanto, pouco se sabe sobre a possível função ou via de ação da Ang-(1-7) na ovulação.…”

Section: Introductionunclassified

“…Em ratas, os níveis ovarianos de Ang-(1-7) estão mais elevados no proestro e estro, quando comparados aos níveis do metaestro e diestro (COSTA et al, 2003). Os mesmos autores demonstraram que Ang-(1-7) induz um aumento nas concentrações de estradiol e progesterona, sendo esse efeito inibido por A-779.…”

Section: Introductionunclassified

“…Isso demonstra que a Ang-(1-7) utiliza receptor específico para atuar na esteroidogênese em roedores. A localização da Ang-(1-7) e do receptor MAS nas células intersticiais e tecais de folículos antrais e pré-ovulatórios de ratas tratadas com eCG também já foram observadas (COSTA et al, 2003;PEREIRA et al, 2009). Foi também demonstrado que a expressão de RNAm para MAS e para a enzima conversora de angiotensina 2 (ECA 2 ), responsável pela clivagem de Ang II em Ang-(1-7), aumenta em homogenatos de ovário de ratas tratadas com eCG (PEREIRA et al, 2009).…”

Section: Introductionunclassified

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Angiotensina-(1-7) durante o processo inicial na cascata da ovulação em bovinos

et al. 2012

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Increased formation of corpora lutea in neurokinin 1‐receptor deficient mice

Löffler¹,

Schulz²,

Hunt

et al. 2004

Molecular Reproduction Devel

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There is evidence to suggest that the tachykinin-receptor system may be involved in female reproduction. Recently, we have shown that the mRNA transcripts of the preprotachykinin-A which encodes substance P (SP), a member of the tachykinin family, and of NK1-R (preferred receptor of SP) are expressed in the bovine corpus luteum (CL) of early developmental stage. The question arises whether the system is expressed at the protein level and influences the ovulatory process and CL formation. For this reason, ovaries from a mouse mutant in which the NK1-R gene had been disrupted were studied. By using RT-PCR, mRNA expression of NK1-R was confirmed in both the ovary and the uterus of wild-type mice. Weaning frequency and litter size, as recorded over 6 months, were similar in both groups. However, counting of CL in serial paraffin sections revealed a significant higher number of CL in the NK1-R deficient mice in comparison to the wild-type group (P < 0.01). The increased formation of CL in NK1-R deficient mice corresponded to a considerable number of CL with retained oocyte not found in ovaries of the wild-type group. We conclude: The CL with a retained oocyte may indicate that the muscular apparatus of the preovulatory follicle plays a role in oocyte expulsion and that contractility of the follicle wall is deficient in the mutant group. Our observation may have implications for the luteinized unruptured follicle syndrome in humans.

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Angiotensin-(1–7): A Novel Peptide in the Ovary

Cited by 58 publications

References 42 publications

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Angiotensina-(1-7) durante o processo inicial na cascata da ovulação em bovinos

Increased formation of corpora lutea in neurokinin 1‐receptor deficient mice

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