Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

Rohman, Mohammad Saifur; Fajar, Jonny Karunia; Kuncahyo, Bagus H.; Yunita, Lowry; Sidarta, Erdo Puncak; Saka, Putu Nina Belinda; Heriansyah, Teuku; Widodo, Nashi

doi:10.1016/j.ejmhg.2018.05.006

Cited by 11 publications

(7 citation statements)

References 39 publications

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“…On other hand, gene-gene interaction study also supported our perspectives. They found that AT1R A1166C was linked to ACE I/D [75], and our previous study also revealed that ACE I/D gene polymorphism was correlated with hypertension [14]. In addition, AT1R A1166C gene polymorphism was also investigated in patients with hypertension-related condition, such as coronary artery disease and heart failure.…”

Section: Discussionmentioning

confidence: 92%

“…To achieve our purpose, papers published in PubMed, Embase, Cochrane, and Web of science were searched and identified in accordance with eligibility criteria, and they were analyzed to determine the pooled odds ratio (OR) and 95% confidence interval (95%CI) using fixed or random effect model. The design of our present study was adapted from our previous meta-analyses [11][12][13][14][15].…”

Section: Methodsmentioning

confidence: 99%

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The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Fajar

Susanti

Pikir

et al. 2019

Egypt J Med Hum Genet

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Background: Since first reported having the association with essential hypertension, angiotensin II type 1 receptor (AT1R) A1166C was globally investigated worldwide. However, controversy was found. Furthermore, previous metaanalyses did not adequate to clarify the precise correlation due to some limitations. Therefore, we aimed to perform a meta-analysis concerning the association between AT1R A1166C single-nucleotide polymorphism (SNP) and the risk of essential hypertension with eliminating the limitations of previous studies. Methods: A meta-analysis was conducted from February to March 2019. Some information related to sample size of hypertension and control groups and genotype frequencies of hypertension and control groups were extracted from each study. Data were analyzed using fixed or random effect model to determine the overall correlation. Results: A total of 45 papers consisting of 11911 cases and 1340 controls were enrolled for the study. Our overall analysis showed that C allele and AC genotype of AT1R A1166C was associated with 1.18-fold and 1.15-fold respectively increased risk of essential hypertension, while the decreased risk of essential hypertension was observed in A allele and AA genotype. In subgroup analysis, increased risk of essential hypertension was found in C allele, AC genotype, and CC genotype of both Asian population and PCR-RFLP subgroups , while decreased risk was observed in A allele and AA genotype. Conclusions: Our meta-analysis reveals that AT1R A1166C remains a valuable SNP having an association with the risk of essential hypertension.

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Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Fajar

Susanti

Pikir

et al. 2019

Egypt J Med Hum Genet

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“…DNA was extracted using standard protocols adapted from previous studies. 11 , 20 , 21 , 22 A set of primers (forward 5′-CTGACGAATGTGATGGCCGC-3′ and reverse 5′-TTGATGAGTTCCACGTATT TCG-3′) was designed to cover the polymorphic region of the ACE G2350A gene. A thermal cycler (Perkin Elmer 2400, Boston, USA) was used to amplify the DNA.…”

Section: Methodsmentioning

confidence: 99%

“…These mechanisms are the forerunners for the development of hypertension. 10 , 11 Therefore, it has been hypothesized that ACE may possess a potential correlation with these aggravating factors that include hypertension, BHV, level of consciousness, and disease outcome among ICH patients. The ACE G2350A gene is one of ACE genes that play a significant role in determining the ACE level within the circulation.…”

Section: Introductionmentioning

confidence: 99%

Association of angiotensin-converting enzyme G2350A gene polymorphisms with hypertension among patients with intracerebral haemorrhage

Imran

Syahrul

Sofia

et al. 2019

Journal of Taibah University Medical Sciences

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Objectives To evaluate the correlation of angiotensin-converting enzyme (ACE) G2350A gene polymorphisms with hypertension, brain hematoma volume (BHV), level of consciousness, and disease outcome among intracerebral haemorrhage (ICH) patients. Methods A cross-sectional study was conducted in Zainoel Abidin General Hospital from May 2016 to June 2017. Polymerase chain reaction was used to genotype ACE G2350A gene polymorphisms. BHV was assessed using the ABC/2 volume estimation formula. Level of consciousness was assessed by Glasgow coma scale (GCS). Disease outcome was assessed using Glasgow outcome scale (GOS). Association tests for ACE G2350A genotype in the context of hypertension status, BHV, GCS score, and GOS score in subjects with ICH was analysed by multiple logistic regression. Results A total of 75 ICH patients were included in the study. Of those, 59 patients exhibited hypertension, 24 patients had BHV ≥60 cm 3 , 16 patients possessed GCS scores ≤8, and 72 patients had GOS scores of 1–3. Our analysis determined that the A allele of the ACE G2350A gene polymorphism was significantly associated with a 3.6-fold increase in hypertension; however, this polymorphism was not associated with BHV, level of consciousness, and disease outcome among ICH patients. Conclusion The A allele of the ACE G2350A gene polymorphisms is associated with hypertension among ICH patients.

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“…To reach this purpose, published papers from PubMed, Embase, Cohcrane, and Web of science were collected for calculation of odd ratio (OR) and 95% confidence interval (95%CI) using either random or fixed effect model. The protocols in our current study including papers selection, data extraction, quality assessment, and statistical analysis were adapted from our previous meta-analyses [19][20][21][22], and we also used the checklist of the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) to guide the protocols in our study [23].…”

Section: Methodsmentioning

confidence: 99%

Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

Daryanto

Purnomo

Gunawan

et al. 2019

Egypt J Med Hum Genet

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Backgrounds: In the last two decades, studies have been widely carried out to assess the association between singlenucleotide polymorphisms (SNPs) of calcium-sensing receptor (CaSR) gene in exon 7 and the risk of urolithiasis. However, inconsistency across the studies was reported. Therefore, our current study aimed to perform a meta-analysis concerning the association between the risk of urolithiasis and the gene polymorphisms of CaSR R990G, CaSR A986S, and CaSR Q1011E. Methods: Published papers from PubMed, Embase, Cohcrane, and Web of science were included for the study, and they were analyzed using fixed or random effect model. Results: A total of 11 papers consisting of eight papers evaluating CaSR R990G, nine papers evaluating CaSR A986S, and five papers evaluating CaSR Q1011E were included in our analysis. Our pooled calculation found that protective effect against urolithiasis was observed in R allele and RR genotype of CaSR R990G and A allele and AA genotype of CaSR A986S. Conversely, increased susceptibility to urolithiasis was found in G allele and RG genotype of CaSR R990G and S allele of CaSR A986S. Interestingly, our findings in subgroup analysis confirmed that the correlation between CaSR R990G and urolithiasis was found in Caucasian population. Meanwhile, in Asian population, the association was observed in CaSR A986S. Conclusions: CaSR R990G and CaSR A986S, but not CaSR Q1011E, are associated with the risk of urolithiasis.

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Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

Cited by 11 publications

References 39 publications

The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Association of angiotensin-converting enzyme G2350A gene polymorphisms with hypertension among patients with intracerebral haemorrhage

Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

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