Angiotensin II and Angiotensin-Converting Enzyme as Candidate Compounds Modulating the Effects of Testis Ecdysiotropin in Testes of the Gypsy Moth,Lymantria dispar1

Loeb, Marcia J.; Loof, Arnold De; Schoofs, Liliane; Isaac, Elwyn

doi:10.1006/gcen.1998.7169

Cited by 19 publications

(17 citation statements)

References 26 publications

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“…A 20E-induced synthesis of ACE-like activity was also observed in D. melanogaster (Siviter et al, 2002) and in A. stephensi (Ekbote et al, 1999). Moreover, Loeb et al (1998) demonstrated that ACE-activity stimulates ecdysteroid synthesis, perhaps due to feedback effects. The experiments showed that both bovine ACE and bovine angiotensin II stimulate the synthesis of ecdysteroids by testis of L. dispar larvae and pupae, and yet inhibit the action of testis ecdysiotropin, a neuropeptide reported to be responsible for stimulating ecdysteroid production by testes.…”

Section: Discussionmentioning

confidence: 77%

“…Since treated insects displayed normal blood digestion and a normal development of oocytes, it is possible that ACE-inhibitors interfere with oocyte transfer along the oviducts. The report that ACE-like activity has been localized in the reproductive organs of both male and female insects provides additional evidence supporting a role for ACE in reproduction Loeb et al, 1998). In Lacanobia oleracea, the highest level of ACE activity was found in the reproductive tract.…”

Section: Discussionmentioning

confidence: 95%

“…Several recent studies provide evidence for reciprocal interactions between ACE and ecdysteroid production (Loeb et al, 1998;Quan et al, 2001;Vandingenen et al, 2001;Siviter et al, 2002). Quan et al (1998) reported that BmAcer expression is ecdysone-inducible.…”

Section: Discussionmentioning

confidence: 97%

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The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Vercruysse

Gelman

Raes

et al. 2004

Arch Insect Biochem Physiol

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The role of angiotensin converting enzyme (ACE, peptidyl dipeptidase A) in metamorphic- and reproductive-related events in the Egyptian cotton leafworm, Spodoptera littoralis (Lepidoptera, Noctuidae) was studied by using the selective ACE inhibitor captopril. Although oral administration of captopril had no effect on larval growth, topical administration to new pupae resulted in a large decrease of successful adult formation. Oviposition and overall appearance of adults emerging from treated larvae did not differ significantly from those emerging from non-treated larvae. In contrast, topical or oral administration of captopril to newly emerged adults caused a reduction in oviposition. By evaluating the effect of captopril on ecdysteroid titers and trypsin activity, we revealed an additional physiological role for ACE. Captopril exerted an inhibitory effect on ecdysteroid levels in female but not in male adults. Larvae fed a diet containing captopril exhibited increased trypsin activity. A similar captopril-induced increase in trypsin activity was observed in female adults. In male adults, however, captopril elicited reduced levels of trypsin activity. Our results suggest that captopril downregulates oviposition by two independent pathways, one through ecdysteroid biosynthesis regulation, and the other through regulation of trypsin activity. Apparently, fecundity is influenced by a complex interaction of ACE, trypsin activity, and ecdysteroid levels.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 95%

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The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Vercruysse

Gelman

Raes

et al. 2004

Arch Insect Biochem Physiol

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“…Angiotensin blockers, including triterpene such as oleanolic and b-glycyrrhetinic acids, induced ecdysteroid secretion in the lepidopteran Lymantria dispar (Caballero-George et al 2004;Loeb et al 1998), suggesting that these triterpenes could interfere with the insect's ecdysteroid levels. Triterpenes such as oleanolic and ursolic acids have fluidity-modulating effects on liposomal membranes (Han et al 1997).…”

Section: Postingestive and Cytotoxic Effectsmentioning

confidence: 98%

Triterpene-based plant defenses

et al. 2010

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Pentacyclic triterpenes are abundant in the plant kingdom and have a wide array of pharmacological activities. They also have insect antifeedant effects and therefore apparently play a role in plant defense. In this paper, we describe the insecticidal activity of pentacyclic triterpenes of plant origin from different chemical classes on several insect pests (Spodoptera littoralis, Leptinotarsa decemlineata and Myzus persicae), their phytotoxic properties and their selective cytotoxic effects on insect-derived Sf9 and mammalian CHO cells. We also discuss the role they play in plant defense based on these activities.

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“…ACE homologues have recently been discovered in sev eral insect species (Isaac & Lamango, 1994;Loeb et al, 1998;Schoofs et al, 1998;Ekbote et al, 1999;Zhu et al, 2001a, b;Vandingenen et al, 2002). Although we have indicated that the Neobellieria bullata trypsin modulating oostatic factor (NebTMOF) is a putative in vivo substrate for Neb ACE (Vandingenen et al, 2001), the exact physiological relevance of insect ACE remains obscure Veelaert et al, 1999;Seinsche et al, 2000) .…”

Section: Introductionmentioning

confidence: 67%

Isolation of angiotensin converting enzyme from testes of Locusta migratoria (Orthoptera)

Macours¹,

Vandingenen²,

Gielens³

et al. 2003

Eur. J. Entomol.

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Abstract. By means of a tracer assay using a labeled synthetic angiotensin converting enzyme (ACE) substrate hippurylglycylglycine, we have detected high ACE activity in the testes of the African migratory locust, Locusta migratoria. Lower, but significant, ACE activity was observed in midgut and hemolymph. In a two-step purification procedure involving anion exchange and gel permeation chromatography, we have purified LomACE from the locust testes. The enzyme of approximately 80 kDa shows substantial amino-acid sequence homology with ACE from both vertebrate and invertebrate origin. The ACE identity of the purified enzyme was further confirmed by cDNA cloning of the Locusta ACE fragment, which, after in silico translation, revealed a mature protein of 623 amino acids with a large structural similarity to other known ACE proteins.

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Angiotensin II and Angiotensin-Converting Enzyme as Candidate Compounds Modulating the Effects of Testis Ecdysiotropin in Testes of the Gypsy Moth,Lymantria dispar1

Cited by 19 publications

References 26 publications

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Triterpene-based plant defenses

Isolation of angiotensin converting enzyme from testes of Locusta migratoria (Orthoptera)

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