Animal models of erectile dysfunction

Gajbhiye, Snehlata V.; Jadhav, Kshitij S.; Marathe, Padmaja A; Pawar, Dattatray B

doi:10.4103/0970-1591.128496

Cited by 20 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Note that preinjury mount ICP (n ϭ 16) was significantly lower than ICP of both intromissions and ejaculations (P Ͻ 0.001; Fig. 2), a finding consistent with previous studies by other groups (18).…”

Section: Resultssupporting

confidence: 90%

“…Such methodologies have included intracavernosal pressure (ICP) and intraspongiosal pressure (ISP) recordings in response to cavernous nerve, pelvic plexus, and dorsal nerve of the penis electrical stimulation or pharmacologically induced erections (54). Additionally, mating tests and ex copula sexual reflex tests, noncontact erection test (18), and electromyogram of perineal musculature during mating tests (44,52) have all been used in measuring sexual function. Limitations from such studies include nonphysiological test settings, use of anesthesia, lack of robust objective quantification (regarding mating tests and ex copula sexual reflexes), and single time point of testing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Telemetric monitoring of penile pressure during mating in rats after chronic spinal cord injury

Steadman

Vangoor

Hubscher

2019

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

In men with a spinal cord injury (SCI), erectile function, ejaculation, and fertility are severely impaired. The present study utilized a telemetric pressure transducer implanted into the corpus cavernosum of the penis to examine sexual function during awake mating behavior in a rat contusion model with a range of Infinite Horizon Impactor forces distributed between 150 and 215 kdyn. The mating behavior paradigm included examination of the counts, average pressure, and average duration for mounts, intromissions, and ejaculations. Male Wistar rats were mated with receptive females in 30-min sessions preinjury (sexual acclimation) and once per week for 6 wk beginning after a 2-wk recovery period post-SCI. All SCI animals had significant deficits in sexual function in the parameters measured. These deficiencies were more prevalent in a subset having less than 20% white matter sparing, likely a reflection of the extent of bilateral spino-bulbo-spinal sexual circuitry disruption at the lesion epicenter. The resulting discoordination of the autonomic and somatic reflex control of erection and ejaculation recorded using telemetry devices in an awake, behaving animal model provides an effective means of gauging sexual function deficits after SCI and could have utility for quantifying recovery after a therapeutic intervention.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Telemetric monitoring of penile pressure during mating in rats after chronic spinal cord injury

Steadman

Vangoor

Hubscher

2019

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…In addition, in sexual dysfunction field, there are different animal models to study the ED mainly based on nerve stimulation, to measure the intracavernous pressure (ICP); on sexual behavior in conscious animals, such as mating and copulation studies; or on specific predisposing conditions, that usually are aging, radiation, arteriogenic, diabetic or obesity associated ED models (Gajbhiye et al, 2015 ; Wu and Kovac, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage

et al. 2017

View full text Add to dashboard Cite

Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were developed, however the high price of special animals or the long period to establish the disease has limited studies in this field. Therefore, this study proposed to establish and characterize a novel model of ED in rats associated to a hypercaloric diet consumption. Animals were randomly divided into control group (CG), which received a standard diet, and obese group (OG), fed with a hypercaloric diet during 8 weeks. Rat's erectile function was evaluated in vivo and in vitro. Food and caloric intake of OG were reduced compared to CG, due to an increased diet energy efficiency. However, OG presented an increased body mass, inguinal, retroperitoneal and epididymal adipose tissues, as well as body adiposity index at the end of experimental protocol. In erectile function analysis, there was a decrease in the number and the latency of penile erections in OG. Additionally, the contractile reactivity of corpus cavernosum was increased in OG, favoring penile detumescence and related to a reduced nitric oxide bioavailability and an increased in contractile prostaglandins levels as a consequence of endothelial damage. Moreover, the endothelium-relaxation reactivity of corpus cavernosum was attenuated in OG associated to the oxidative stress. Thus, it was provided a model for advances in sexual dysfunction field and drug discovery for ED treatment.

show abstract

“…Thus, CN-injury-related conduction deficits, as well as the functional effects of restorative interventions, can also be objectively assessed by comparative analysis of the modifications in intra-corporeal pressure (ICP) values in relation to mean arterial pressure (MAP), achieved through standardized electrostimulation of the CNs, before and after injury induction and therapeutic intervention, respectively. Finally, the cost-effectiveness of rat models constitutes an equally important practical advantage [ 46 ].…”

Section: The Cavernous Nerve Lesion Rat Modelmentioning

confidence: 99%

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

Novacescu

Neşiu

Bardan

et al. 2023

JCM

View full text Add to dashboard Cite

In the contemporary era of early detection, with mostly curative initial treatment for prostate cancer (PC), mortality rates have significantly diminished. In addition, mean age at initial PC diagnosis has decreased. Despite technical advancements, the probability of erectile function (EF) recovery post radical prostatectomy (RP) has not significantly changed throughout the last decade. Due to virtually unavoidable intraoperative cavernous nerve (CN) lesions and operations with younger patients, post-RP erectile dysfunction (ED) has now begun affecting these younger patients. To address this pervasive limitation, a plethora of CN lesion animal model investigations have analyzed the use of systemic/local treatments for EF recovery post-RP. Most promisingly, neuregulins (NRGs) have demonstrated neurotrophic effects in both neurodegenerative disease and peripheral nerve injury models. Recently, glial growth factor 2 (GGF2) has demonstrated far superior, dose-dependent, neuroprotective/restorative effects in the CN injury rat model, as compared to previous therapeutic counterparts. Although potentially impactful, these initial findings remain limited and under-investigated. In an effort to aid clinicians, our paper reviews post-RP ED pathogenesis and currently available therapeutic tools. To stimulate further experimentation, a standardized preparation protocol and in-depth analysis of applications for the CN injury rat model is provided. Lastly, we report on NRGs, such as GGF2, and their potentially revolutionary clinical applications, in hopes of identifying relevant future research directions.

show abstract

Animal models of erectile dysfunction

Cited by 20 publications

References 40 publications

Telemetric monitoring of penile pressure during mating in rats after chronic spinal cord injury

Telemetric monitoring of penile pressure during mating in rats after chronic spinal cord injury

Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

Contact Info

Product

Resources

About