Anisotropic and robust hydrogels combined osteogenic and angiogenic activity as artificial periosteum

He, Xiangheng; Li, Wenyan; Liu, Kun; Wen, Wei; Lu, Lu; Zhou, Changren; Luo, Binghong

doi:10.1016/j.compositesb.2022.109627

Cited by 18 publications

(21 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After CG was perfused into P@C4–, cells were more widely distributed on the scaffold, which indicated that cells on CG own the great ability of migration and proliferation. Compared with the P@CG scaffold, the surface of the P@CG-D scaffold was almost completely covered by BMSCs, revealing the positive effects of DFO on improving cell migration and proliferation. , The enlarged LSCM images further confirmed the good cell adhesion and spreading behaviors on P@CG and P@CG-D. Cells on P@CG scaffold not only exhibited the highest spreading area, the actin filaments that make up the cytoskeleton are also highly expressed, implying a very strong interaction between cells and CG .…”

Section: Resultsmentioning

confidence: 99%

Bone ECM-like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

Liu

Chen

et al. 2022

ACS Nano

Self Cite

View full text Add to dashboard Cite

Implanting a 3D printing scaffold is an effective therapeutic strategy for personalized bone repair. As the key factor for the success of bone tissue engineering, the scaffold should provide an appropriate bone regeneration microenvironment and excellent mechanical properties. In fact, the most ideal osteogenic microenvironment is undoubtedly provided by natural bone extracellular matrix (ECM), which exhibits liquid crystalline and viscoelastic characteristics. However, mimicking a bone ECM-like microenvironment in a 3D structure with outstanding mechanical properties is a huge challenge. Herein, we develop a facile approach to fabricate a bionic scaffold perfectly combining bone ECM-like microenvironment and robust mechanical properties. Creatively, 3D printing a poly(L-lactide) (PLLA) scaffold was effectively strengthened via layer-by-layer electrostatic self-assembly of chitin whiskers. More importantly, a kind of chitin whisker/chitosan composite hydrogel with bone ECM-like liquid crystalline state and viscoelasticity was infused into the robust PLLA scaffold to build the bone ECM-like microenvironment in 3D structure, thus highly promoting bone regeneration. Moreover, deferoxamine, an angiogenic factor, was encapsulated in the composite hydrogel and sustainably released, playing a long-term role in angiogenesis and thereby further promoting osteogenesis. This scaffold with bone ECMlike microenvironment and excellent mechanical properties can be considered as an effective implantation for bone repair.

show abstract

Section: Resultsmentioning

confidence: 99%

Bone ECM-like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

Liu

Chen

et al. 2022

ACS Nano

Self Cite

View full text Add to dashboard Cite

show abstract

“…As-developed composite hydrogels with outstanding mechanical properties (tensile strength: 17.6 ± 1.4 MPa and Young's modulus: 28.1 ± 2.2 MPa) exhibited not only adequate cell attachment and proliferation but also have the remarkable ability to ease osteogenesis and angiogenesis of the cells, which could be used for the artificial periosteum. 87 The study offered the idea of developing smart hydrogels with the ability to support and accelerate the growth of the vascular network that supports bone.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Manufacturing functional hydrogels for inducing angiogenic–osteogenic coupled progressions in hard tissue repairs: prospects and challenges

et al. 2022

View full text Add to dashboard Cite

show abstract

“…4,5 Furthermore, the periosteum can also provide sufficient mechanical support and maintain structural stability for bone tissue repair, which plays a key role in the development and regeneration of bone tissue. 2,6,7 Therefore, damage or loss of periosteum may delay the process of bone regeneration or even cause permanent nonunion. 8 Luckily, some artificial periostea based on acellular matrix membranes, 9 growth factor-loaded micro-/nanofibrous membranes, 10 and mineralized membranes 4 that can promote bone regeneration have been developed in recent years.…”

Section: ■ Introductionmentioning

confidence: 99%

“…As an important part of normal bone tissue, periosteum is a thin, tough, and dense connective tissue membrane covering the external surface of bone. , Histological study of the periosteal structure indicated that the diaphysis is mainly composed of axially arranged collagen and high-density elastin, which endows the periosteum with anisotropy and elasticity in mechanics . In the process of bone defect repair, the periosteum not only acts as a physical and cellular barrier to prevent the invasion of soft tissue cells such as fibroblasts but also provides growth factors for the defect site and recruits osteoblasts to accelerate the regeneration of bone tissue. , Furthermore, the periosteum can also provide sufficient mechanical support and maintain structural stability for bone tissue repair, which plays a key role in the development and regeneration of bone tissue. ,, Therefore, damage or loss of periosteum may delay the process of bone regeneration or even cause permanent nonunion . Luckily, some artificial periostea based on acellular matrix membranes, growth factor-loaded micro-/nanofibrous membranes, and mineralized membranes that can promote bone regeneration have been developed in recent years.…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities

Chen

Zhu

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Current artificial periostea mainly focus on osteogenic activity but overlook structural and mechanical anisotropy, as well as the importance of antibacterial and anti-inflammatory properties. Here, inspired by the anisotropic structure of wood, the delignified wood (named white wood, WW) with a porous and highly oriented cellulose fiber skeleton was obtained, which was further filled with polyvinyl alcohol (PVA) hydrogel loaded with curcumin (Cur) and phytic acid (PA). The prepared wood-derived hydrogel composite membranes can not only exhibit an obvious anisotropic structure and good mechanical properties but also sustainably release loaded drugs to obtain long-term biological activities. Creatively, PA can effectively improve the bioavailability of Cur; more importantly, Cur and PA play an obvious synergistic effect in antibacterial, anti-inflammatory, and osteogenic activities. Compared with the woodderived hydrogel composite membranes without drug loading, as well as loaded with Cur or PA only, these loaded with Cur and PA are significantly more conducive to inhibiting the growth of bacteria and inflammatory response and facilitating the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. This kind of anisotropic woodderived hydrogel composite membrane with fantastic antibacterial, anti-inflammatory, and osteogenic activities is expected to be ideal artificial periostea.

show abstract

Anisotropic and robust hydrogels combined osteogenic and angiogenic activity as artificial periosteum

Cited by 18 publications

References 47 publications

Bone ECM-like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

Bone ECM-like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

Manufacturing functional hydrogels for inducing angiogenic–osteogenic coupled progressions in hard tissue repairs: prospects and challenges

Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities

Contact Info

Product

Resources

About