Anonychia as a Recessive Autosomal Trait in Man

Littman, Armand; Levin, Seymour R.

doi:10.1038/jid.1964.37

Cited by 19 publications

(15 citation statements)

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“…In all except the cases of Littman and Levin (1964) the anonychia appears to have been total; the fingers as well as toes being affected. It is still not possible to say if all these cases are due to mutations at the same loci or that there is further heterogeneity.…”

Section: Discussionmentioning

confidence: 89%

“…More recently, Littman and Levin (1964) suggestion but this mode of inheritance has not yet gained general acceptance (McKusick, 1968). The purpose of the present communication is to report a >.…”

mentioning

confidence: 99%

“…From Britain, O'Neill (1916) reported complete absence of all nails in 3 sibs. Finally, Littman and Levin (1964) Consanguineous marriages are very common in Iran particularly in villages and small towns. A recent survey carried out in a number of villages in the vicinity of Shiraz (Mahloudji and Livingston, in press) showed that over 20% of all marriages were between second cousins or closer relatives.…”

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confidence: 99%

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Simple anonychia. Further evidence for autosomal recessive inheritance.

Mahloudji¹,

Amidi²

1971

Journal of Medical Genetics

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Section: Discussionmentioning

confidence: 89%

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confidence: 99%

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confidence: 99%

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Simple anonychia. Further evidence for autosomal recessive inheritance.

Mahloudji¹,

Amidi²

1971

Journal of Medical Genetics

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“…In exceptional cases, absence (anonychia) [22][23][24] or severe hypoplasia (onychoatrophia, micronychia, hyponychia) 22,25 of 1 or more nails follow dominant and recessive patterns of inheritance. 4,26 Furthermore, koilonychia, 27 trachyo- Figure 6.…”

Section: Commentmentioning

confidence: 99%

Isolated Congenital Nail Dysplasia

Hamm

Karl²,

Bröcker³

2000

Arch Dermatol

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Developmental nail abnormalities are extremely heterogeneous, with hereditary isolated conditions being a small and rare subgroup. An unusual congenital nail dysplasia observed in a large South German kindred was characterized clinically to review the question of uniqueness.Design: Case series of affected family members.Setting: University department of dermatology and houses of patients. Patients:The history and clinical features in 22 affected family members (13 females and 9 males, aged 5 to 74 years) were recorded and documented by photographs. Nail biopsy samples were taken from 2 patients. Interventions: None.Results: The pedigree spanning 5 consecutive generations was best compatible with autosomal dominant in-heritance with complete penetrance. Nail alterations were mostly present since birth and soon reached an individually variable degree of severity. Affected persons showed longitudinal streaks and thinning of nail plates, mostly of all fingernails and toenails, with some accentuation of the thumbnail and big toenails, poorly developed lunulae, longitudinal angular ridges of individual nail plates occasionally starting proximally from a reddish prominence, platonychia and koilonychia of individual nails often overgrowing the lateral folds, and notches and fissures of the free margins. Histological abnormalities included a prominent granular layer of the nail matrix and epithelial strands and buds extending from the nail bed. There were no associated anomalies. Other nail dystrophies were excluded by differences in clinical and histological features. Conclusion:The nail abnormality observed in our family represents a new autosomal dominant disorder for which we propose the term isolated congenital nail dysplasia.

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“…Inheritance is either autosomal dominant or recessive. For reviews and case reports see Littman and Levin (1964), Timerman et al (1969), Mahloudji and Amidi (1971), and McKusick (1975).…”

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confidence: 99%