Antenatal diagnosis of agenesis of the corpus callosum

Craven, Ian; Bradburn, Michael; Griffiths, Paul D.

doi:10.1016/j.crad.2014.11.004

Cited by 43 publications

(39 citation statements)

References 23 publications

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“…Ultrasound guidelines suggest reserving MRI examination to those fetuses where there is a suspicion of abnormality on ultrasound . The ability of MRI to detect abnormalities not seen on ultrasound in this group of patients is as yet unknown, although evidence from other cohorts suggests that significant abnormalities may be detected …”

Section: Fetal Neurological Assessment and Antenatal Diagnosismentioning

confidence: 91%

“…67 The ability of MRI to detect abnormalities not seen on ultrasound in this group of patients is as yet unknown, although evidence from other cohorts suggests that significant abnormalities may be detected. 66 The majority of fetal MRI is still being carried out at 1.5 T, but several units are using 3 T for research and clinical practice. Fetal MRI is usually acquired without resorting to maternal sedation, but as for any MRI examination maternal contraindications include: claustrophobia, metallic implants, some cardiac pacemakers, being overweight or obese (new wide-bore magnets with a diameter of 70 cm [rather than 60 cm] may be better tolerated by those with a high BMI or with claustrophobia).…”

Section: Fetal Brain Mri Assessment In Chdsmentioning

confidence: 99%

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The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

Pasupathy¹,

Denbow²,

Rutherford³

et al. 2019

BJOG

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Plain language summary Heart problems are common in newborn babies, affecting approximately 5–10 in 1000 babies. Some are more serious than others, but most babies born with heart problems do not have other health issues. Of those babies who have a serious heart problem, almost 1 in 4 will have heart surgery in their first year. In the UK, pregnant women are offered a scan at around 20 weeks to try and spot any heart problems. In most cases there is not a clear reason for the problem, but sometimes other issues, such as genetic conditions, are discovered. In recent years the care given to these babies after they are born has improved their chances of surviving. However, it is recognised that babies born with heart problems have a risk of delays in their learning and development. This may be due to their medical condition, or as a result of surgery and complications after birth. In babies with heart problems, there is a need for more research on ultrasound and magnetic resonance imaging (MRI) to understand how the brain develops and why these babies are more likely to have delays in learning and development. This paper discusses the way ultrasound and MRI are used in assessing the baby's brain. Ultrasound is often used to spot any problems, looking at how the baby's brain develops in pregnancy. Advances in ultrasound technologies have made this easier. MRI is well‐established and safe in pregnancy, and if problems in the brain have been seen on ultrasound, MRI may be used to look at these problems in more detail. While it is not always clear what unusual MRI findings can mean for the baby in the long term, increased understanding may mean parents can be given more information about possible outcomes for the baby and may help to improve the counselling they are offered before their baby's birth.

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Section: Fetal Neurological Assessment and Antenatal Diagnosismentioning

confidence: 91%

Section: Fetal Brain Mri Assessment In Chdsmentioning

confidence: 99%

The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

Pasupathy¹,

Denbow²,

Rutherford³

et al. 2019

BJOG

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“…For example, the absence of the cavum septum pellucidum (CSP) and teardrop‐configured lateral ventricles, with possible ventriculomegaly (VM), raise suspicions that there is agenesis of the corpus callosum (ACC). A more definitive diagnosis is usually made through the nonvisualization of the corpus callosum (CC) in either sagittal or coronal plane …”

Section: Introductionmentioning

confidence: 99%

Utility of indirect sonographic signs (including cavum septum pellucidum ratio) in midgestational screening for partial agenesis of corpus callosum

Zhao

Wang

Cai

2019

J of Clinical Ultrasound

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Purpose This study was undertaken to evaluate the performance of indirect sonographic signs in detecting partial agenesis of the corpus callosum (pACC) at midgestation, focusing on the cavum septum pellucidum (CSP) ratio. Methods A retrospective case‐controlled study of singleton pregnancies was conducted, examining fetuses diagnosed with isolated pACC and normal controls. At midgestational age, fetal head volumes were imaged with 3D US and stored for the evaluation of indirect sonographic findings in axial planes. Results Fifteen normal and 15 abnormal fetuses (with pACC) were analyzed. Based on a CSP ratio < 1.5, detection of pACC increased from 66.7% (10/15) to 80% (12/15). All indirect signs proved highly suspicious for pACC (risk ratios > 1). Conclusion Use of indirect sonographic signs to screen for pACC at midgestation is challenging. However, a low CSP ratio may improve the detection rate, serving as a new indirect sign.

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“…The findings in this case suggest that CT angiography or MRI may detect persistent POA more effectively in cases involving ACC. is complete in its craniocaudal extent by 18 to 19 weeks, although further maturation and growth continues into postnatal life [1]. Early disruption in the maturation of the corpus callosum can lead to a developmental condition known as ACC, a relatively frequent congenital malformation ranging from complete absence to hypo genesis of corpus callosum fibers.…”

Section: Introductionmentioning

confidence: 99%

“…ACC results from commissural defects, and although it can occur for a number of reasons, including genetic, metabolic, or vascular abnormalities, in most cases, the cause remains unknown [1]. Brain anomalies and other malformations associated with ACC include lipoma of the corpus callosum, cerebellar hypoplasia, Dandy-Walker syndrome, hydrocephalus due to obstruction of the foramen of Monro or aqueduct stenosis, interhemispheric cyst, porencephalic cyst, and neuronal migration disorders [2].…”

Section: Introductionmentioning

confidence: 99%

Agenesis of the Corpus Callosum Associated with Persistent Primitive Olfactory Artery - Case Report and Literature Review

Kim¹

2016

Int J Radiol Radiat Oncol

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Citation: Kim MS (2016) Agenesis of the Corpus Callosum Associated with Persistent Primitivedemonstrated suspicious ACC and dilation of the atrium and occipital horns of both lateral ventricles (colpocephaly) (Figure 1). Brain magnetic resonance imaging (MRI) showed radially arrayed gyri pointing to the third ventricle, an absent cingulate gyrus, Probst bundle, total ACC, and anterior commissure (Figure 2). Brain MRI also demonstrated a suspicious persistent POA (Figure 3). Brain CT angiography showed a right persistent POA (Figure 4). Sagittal CT angiography demonstrated a highly located internal cerebral vein ( Figure 5). Open reduction and internal fixation for the mandible fracture were performed on the eighth day after trauma, and the patient was discharged on the 16th day after trauma.

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Antenatal diagnosis of agenesis of the corpus callosum

Cited by 43 publications

References 23 publications

The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

Utility of indirect sonographic signs (including cavum septum pellucidum ratio) in midgestational screening for partial agenesis of corpus callosum

Agenesis of the Corpus Callosum Associated with Persistent Primitive Olfactory Artery - Case Report and Literature Review

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