Antenatal origins of reduced lung function‐but not asthma?

Turner, Steve

doi:10.1111/resp.12794

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…The apparently inconsistent findings between cohorts for associations between fetal size and symptoms may reflect differences in response bias and differences in methodologies, including definitions used and age at assessment. However, there is also a recognised disconnect between reduced lung function and asthma symptoms, and thus a relationship may not be apparent in every population [18].…”

Section: Introductionmentioning

confidence: 99%

First trimester fetal size and prescribed asthma medication at 15 years of age

Turner

Devereux

2018

Eur Respir J

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There is increasing evidence that antenatal factors predispose to childhood asthma. We tested the hypothesis that reduced first trimester fetal size is associated with increased risk for asthma at 15 years of age.Fetal size in the first and second trimester was ascertained by ultrasound scan. The primary outcome of being dispensed one or more asthma medications by the family doctor in the year before the 15th birthday was determined from routinely acquired dispensing data.Dispensing data were available for 1699 (88% of the original cohort) participants at 15 years of age and questionnaire data for 750 (39%). Each reduction in z-score for first trimester size was associated with increased odds for dispensed asthma medication at 15 years of age (OR 1.26, 95% CI 1.03-1.54) and self-reported use of asthma medications (OR 1.55, 95% CI 1.16-2.08). Overall, first and second trimester size and forced expiratory volume in 1 s at ages 5, 10 and 15 years were reduced for those dispensed asthma medications compared with those not dispensed asthma medications (p=0.003).Antenatal factors that are active by the first trimester may contribute to respiratory well-being throughout childhood. Dropout from a birth cohort study can overestimate of the magnitude of any true association.

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Section: Introductionmentioning

confidence: 99%

First trimester fetal size and prescribed asthma medication at 15 years of age

Turner

Devereux

2018

Eur Respir J

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“…77 The intense interest in the developmental origins of respiratory physiology and disease was also highlighted in an interesting paper from Popovic et al 78 using an internet-based birth cohort that found that size and weight gain velocity but not age at peak weight velocity were independently associated with an increased risk of wheezing in the first 18 months of life. Nice summaries and discussions of these findings are found in editorials by Duijts 79 and Turner 80 who reflected that there are early infant origins of wheeze and asthma symptoms and even earlier foetal origins of lung function with other factors including atopy that also likely impact. Of particular note it seems that reduced lung function per se predisposes to, but does not appear to, cause respiratory symptoms and asthma.…”

Section: Claire E Wainwrightmentioning

confidence: 99%

Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

et al. 2017

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“…Different antenatal exposures, mainly maternal smoking, but also alcohol intake and air pollutants, 5–8 as well as hypertensive pregnancy complications, 5 have been linked to impaired lung function in children. Reduced fetal size and growth have also been associated with lower infant lung function, 9–12 whereas less consistent associations were observed with symptoms related to asthma in infancy and childhood 9–13 . A newly published study showed an inverse association between mid‐pregnancy thoracic circumference (TC), adjusted for femur length as a TC/femur length ratio, and infant lung function 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Reduced fetal size and growth have also been associated with lower infant lung function, [9][10][11][12] whereas less consistent associations were observed with symptoms related to asthma in infancy and childhood. [9][10][11][12][13] A newly published study showed an inverse association between mid-pregnancy thoracic circumference (TC), adjusted for femur length as a TC/femur length ratio, and infant lung function. 14 Ultrasound measures related to fetal lung size, such as lung volume (LV) or lung area, as well as TC, have a predictive value for neonatal respiratory outcome and survival in certain pathological conditions such as diaphragmatic hernia and skeletal dysplasia.…”

Section: Introductionmentioning

confidence: 99%

Third trimester fetal lung volume, thoracic circumference, and early infant lung function

Hilde

Guðmundsdóttir

Bains

et al. 2023

Pediatric Pulmonology

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Background We aimed to investigate the relationship between fetal third trimester lung volume (LV), thoracic circumference (TC), fetal weight, as well as fetal thoracic and weight growth, and early infant lung function. Methods Fetal LV, TC and estimated weight were measured with ultrasound at 30 gestational weeks in 257 fetuses from the general population‐based prospective cohort study Preventing Atopic Dermatitis and ALLergies in Children (PreventADALL). Fetal thoracic growth rate and weight increase were calculated using TC and estimated fetal weight measured by ultrasound during pregnancy, and TC and birthweight of the newborn. Lung function was assessed by tidal flow‐volume measurement in awake infants at 3 months of age. The associations between fetal size (LV, TC, and estimated weight) and growth (thoracic growth rate and fetal weight increase) measures and the time to peak tidal expiratory flow to expiratory time ratio (tPTEF/tE) as well as tidal volume standardized for body weight (VT/kg) were analyzed using linear and logistic regression models. Results We observed no associations between fetal LV, TC or estimated fetal weight and tPTEF/tE as a continuous variable, tPTEF/tE < 25th percentile, or VT/kg. Similarly, fetal thoracic growth and weight increase were not associated with infant lung function. Analyses stratified for sex showed a significant inverse association between fetal weight increase and VT/kg (p = 0.02) in girls. Conclusion Overall, fetal third trimester LV, TC, estimated fetal weight, thoracic growth rate and weight increase were not associated with infant lung function at 3 months of age.

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Antenatal origins of reduced lung function‐but not asthma?

Abstract: http://onlinelibrary.wiley.com/doi/10.1111/resp.12718/abstract

Cited by 5 publications

References 10 publications

First trimester fetal size and prescribed asthma medication at 15 years of age

First trimester fetal size and prescribed asthma medication at 15 years of age

Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

Third trimester fetal lung volume, thoracic circumference, and early infant lung function

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