Anterior cingulate dysfunction during choice anticipation in schizophrenia

Quintana, Javier; Wong, Thomas K. F.; Ortiz-Portillo, Elena; Marder, Stephen R.; Mazziotta, John C.

doi:10.1016/j.pscychresns.2004.06.005

Cited by 30 publications

(8 citation statements)

References 71 publications

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“…Absent dACC activation has been reported in patients with schizophrenia during anticipation of reward (Quintana et al, 2004;Abler et al, 2008), and the effects of olanzapine in healthy participants reported by Abler et al (2007) extend to include dorsal anterior cingulate activity (proximally located to the peak voxel that correlated with SW in this study) which was one of three regions, including the VS, reduced by olanzapine compared to placebo during reward-related processing. Healthy volunteers also show reduced anterior cingulate activity after AMPT-related dopamine depletion (de Silva Alves et al, 2010).…”

Section: Discussionsupporting

confidence: 41%

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

2014

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In patients with schizophrenia, reduced activation of the dACC during multiple aspects of reward processing is associated with lower SW. As the dACC has been widely linked to coupling of reward and action, and the link to SW is apparent over anticipation and outcome, these findings suggest that SW deficits in schizophrenia may be attributable to reduced integration of environmental rewarding cues, motivated behaviour and reward outcome.

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Section: Discussionsupporting

confidence: 41%

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

2014

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“…In parallel with studies of the lateral prefrontal cortex in schizophrenia, hypofrontality of the medial-wall region has also been consistently reported in this disorder and linked to characteristic cognitive deficits of attention and executive function (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Specifically, these studies, when taken with other neuropathological data (16,17), suggest that there exists reduced functional viability of the dorsal anterior cingulate (dAC; or midcingulate cortex) (18) in schizophrenia patients.…”

Section: Introductionmentioning

confidence: 69%

Characterizing anterior cingulate activation in chronic schizophrenia: a group and single‐subject fMRI study

Harrison¹,

Yücel²,

Fornito³

et al. 2007

Acta Psychiatr Scand

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“…The anterior cingulate cortex (ACC) is involved in emotion and behavior (Luu and Posner, 2003 ). The association between ACC and schizophrenia was based on abnormal activation of the ACC during hallucinations (Cleghorn et al, 1990 ) and task performances (Carter et al, 1997 ; Quintana et al, 2004 ) and on histological abnormalities (Benes et al, 2001 ; Bouras et al, 2001 ; Chana et al, 2003 ; Salgado-Pineda et al, 2003 ). The differential protein expression between schizophrenia and non-psychiatric groups was investigated in 4 studies using 2-D PAGE/MS (Beasley et al, 2006 ; Clark et al, 2006 , 2007 ; Martins-de-Souza et al, 2010b ) and one recent study using LC-MS/MS to study expression of proteins in postsynaptic densities (Föcking et al, 2015 ).…”

Section: Candidate Proteins Implicated In Schizophreniamentioning

confidence: 99%

Proteomics Research in Schizophrenia

Davalieva

Kostovska

Dwork

2016

Front. Cell. Neurosci.

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Despite intense scientific efforts, the neuropathology and pathophysiology of schizophrenia are poorly understood. Proteomic studies, by testing large numbers of proteins for associations with disease, may contribute to the understanding of the molecular mechanisms of schizophrenia. They may also indicate the types and locations of cells most likely to harbor pathological alterations. Investigations using proteomic approaches have already provided much information on quantitative and qualitative protein patterns in postmortem brain tissue, peripheral tissues and body fluids. Different proteomic technologies such as 2-D PAGE, 2-D DIGE, SELDI-TOF, shotgun proteomics with label-based (ICAT), and label-free (MSE) quantification have been applied to the study of schizophrenia for the past 15 years. This review summarizes the results, mostly from brain but also from other tissues and bodily fluids, of proteomics studies in schizophrenia. Emphasis is given to proteomics platforms, varying sources of material, proposed candidate biomarkers emerging from comparative proteomics studies, and the specificity of the putative markers in terms of other mental illnesses. We also compare proteins altered in schizophrenia with reports of protein or mRNA sequences that are relatively enriched in specific cell types. While proteomic studies of schizophrenia find abnormalities in the expression of many proteins that are not cell type-specific, there appears to be a disproportionate representation of proteins whose synthesis and localization are highly enriched in one or more brain cell type compared with other types of brain cells. Two of the three proteins most commonly altered in schizophrenia are aldolase C and glial fibrillary acidic protein, astrocytic proteins with entirely different functions, but the studies are approximately evenly divided with regard to the direction of the differences and the concordance or discordance between the two proteins. Alterations of common myelin-associated proteins were also frequently observed, and in four studies that identified alterations in at least two, all differences were downwards in schizophrenia, consistent with earlier studies examining RNA or targeting myelin-associated proteins.

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Anterior cingulate dysfunction during choice anticipation in schizophrenia

Cited by 30 publications

References 71 publications

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

Characterizing anterior cingulate activation in chronic schizophrenia: a group and single‐subject fMRI study

Proteomics Research in Schizophrenia

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